Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Severe erythema multiforme‑type drug eruption controlled by tumor necrosis factor‑α antagonist: A case study

  • Authors:
    • Xin Ling
    • Xin Shi
    • Lingling Chen
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, The First People's Hospital of Wujiang, Affiliated Wujiang Hospital of Nantong University, Suzhou, Jiangsu 215200, P.R. China, Department of Dermatology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China, Department of Dermatology, Suzhou Municipal Hospital, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Ling et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5727-5732
    |
    Published online on: October 18, 2017
       https://doi.org/10.3892/etm.2017.5336
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Using a tumor necrosis factor‑α antagonist, the present study successfully treated a case of severe erythema multiform‑type drug eruption, which occurred following anti‑Helicobacter pylori therapy. A 73‑year‑old female suffering from upper gastrointestinal bleeding and peptic‑ulcer presented with an itchy rash, fever, an increase in leukocytes and eosinophils and lymphadenectasis following oral administration of amoxicillin. Following six subcutaneous injections of etanercept (initially 50 mg, then 25 mg every 3 days), the patient was deemed to have recovered. Following the first injection, the fever was under control. On day 2, the lesions were no longer expanding. On day 4, the rash was markedly less itchy, the swelling decreased, the erythema began to crust and mucosal secretions disappeared. On day 16, the patient was deemed to have recovered and was discharged from the hospital. Her peripheral blood eosinophil count continued to rise following the injection, peaking on day 9. Following this, the count declined slowly, but remained significantly higher than normal when the patient was discharged. The present case indicates that tumor necrosis factor‑α antagonist is a safe, fast and effective treatment for severe drug eruption, but it is unable to prevent the rise of peripheral blood eosinophils.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Kardaun SH and Jonkman MF: Dexamethasone pulse therapy for Stevens-Johnson syndrome/toxic epidermal necrolysis. Acta Derm Venereol. 87:144–148. 2007. View Article : Google Scholar

2 

Hunger RE, Hunziker T, Buettiker U, Braathen LR and Yawalkar N: Rapid resolution of toxic epidermal necrolysis with anti-TNF-alpha treatment. J Allergy Clin Immunol. 116:923–924. 2005. View Article : Google Scholar

3 

Engelhardt SL, Schurr MJ and Helgerson RB: Toxic epidermal necrolysis: An analysis of referral patterns and steroid usage. J Burn Care Rehabil. 18:520–524. 1997. View Article : Google Scholar

4 

Guibal F, Bastuji-Garin S, Chosidow O, Saiag P, Revuz J and Roujeau JC: Characteristics of toxic epidermal necrolysis in patients undergoing long-term glucocorticoid therapy. Arch Dermatol. 131:669–672. 1995. View Article : Google Scholar

5 

Schneck J, Fagot JP, Sekula P, Sassolas B, Roujeau JC and Mockenhaupt M: Effects of treatments on the mortality of Stevens-Johnson syndrome and toxic epidermal necrolysis: A retrospective study on patients included in the prospective EuroSCAR study. J Am Acad Dermatol. 58:33–40. 2008. View Article : Google Scholar

6 

Moghadam-Kia S and Werth VP: Prevention and treatment of systemic glucocorticoid side effects. Int J Dermatol. 49:239–248. 2010. View Article : Google Scholar

7 

Kreft B, Wohlrab J, Bramsiepe I, Eismann R, Winkler M and Marsch WC: Etoricoxib-induced toxic epidermal necrolysis: Successful treatment with infliximab. J Dermatol. 37:904–906. 2010. View Article : Google Scholar

8 

Chen LL, Lu DD, Shi X, Sun XD, Xie LX, Chen XJ, Ding L, Jin WJ and Wang YF: Drug rash with eosinophilia and systemic symptoms controlled by tumor necrosis factor-α antagonist: A clinical observation. Zhonghua Pi Fu Ke Za Zhi. 46:621–625. 2013.(In Chinese).

9 

Bastuji-Garin S, Fouchard N, Bertocchi M, Roujeau JC, Revuz J and Wolkenstein P: SCORTEN: A severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol. 115:149–153. 2000. View Article : Google Scholar

10 

Harr T and French LE: Stevens-Johnson syndrome and toxic epidermal necrolysis. Chem Immunol Allergy. 97:149–166. 2012. View Article : Google Scholar

11 

Miliszewski MA, Kirchhof MG, Sikora S, Papp A and Dutz JP: Stevens-Johnson syndrome and toxic epidermal necrolysis: An analysis of triggers and implications for improving prevention. Am J Med. 129:1221–1225. 2016. View Article : Google Scholar

12 

Lalosevic J, Nikolic M, Gajic-Veljic M, Skiljevic D and Medenica L: Stevens-Johnson syndrome and toxic epidermal necrolysis: A 20-year single-center experience. Int J Dermatol. 54:978–984. 2015. View Article : Google Scholar

13 

Greenberger PA: Drug allergy. J Allergy Clin Immunol. 117 2 Suppl Mini-Primer:S464–S470. 2006. View Article : Google Scholar

14 

Waters JP, Pober JS and Bradley JR: Tumour necrosis factor in infectious disease. J Pathol. 230:132–147. 2013. View Article : Google Scholar

15 

Stefferl A, Hopkins SJ, Rothwell NJ and Luheshi GN: The role of TNF-alpha in fever: Opposing actions of human and murine TNF-alpha and interactions with IL-beta in the rat. Br J Pharmacol. 118:1919–1924. 1996. View Article : Google Scholar

16 

Nakayama M, Niki Y, Kawasaki T, Takeda Y, Horiuchi K, Sasaki A, Okada Y, Umezawa K, Ikegami H, Toyama Y and Miyamoto T: Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha. Arthritis Res Ther. 14:R1202012. View Article : Google Scholar

17 

Doss GP, Agoramoorthy G and Chakraborty C: TNF/TNFR: Drug target for autoimmune diseases and immune-mediated inflammatory diseases. Front Biosci (Landmark Ed). 19:1028–1040. 2014. View Article : Google Scholar

18 

Azzawi M, Hasleton PS and Hutchinson IV: TNF-alpha in acute cardiac transplant rejection. Cytokines Cell Mol Ther. 5:41–49. 1999.

19 

Esposito E and Cuzzocrea S: TNF-alpha as a therapeutic target in inflammatory diseases, ischemia-reperfusion injury and trauma. Curr Med Chem. 16:3152–3167. 2009. View Article : Google Scholar

20 

He M, Dong LM and Hou XB: Time-related expression of IL-6, IL-8 and TNF-alpha following explosive injury to rabbit's chest. Fa Yi Xue Za Zhi. 30:85–87. 2014.(In Chinese).

21 

Paquet P, Nikkels A, Arrese JE, Vanderkelen A and Piérard GE: Macrophages and tumor necrosis factor alpha in toxic epidermal necrolysis. Arch Dermatol. 130:605–608. 1994. View Article : Google Scholar

22 

Carr A, Vasak E, Munro V, Penny R and Cooper DA: Immunohistological assessment of cutaneous drug hypersensitivity in patients with HIV infection. Clin Exp Immunol. 97:260–265. 1994. View Article : Google Scholar

23 

Nassif A, Bensussan A, Dorothée G, Mami-Chouaib F, Bachot N, Bagot M, Boumsell L and Roujeau JC: Drug specific cytotoxic T-cells in the skin lesions of a patient with toxic epidermal necrolysis. J Invest Dermatol. 118:728–733. 2002. View Article : Google Scholar

24 

Paul C, Wolkenstein P, Adle H, Wechsler J, Garchon HJ, Revuz J and Roujeau JC: Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis. Br J Dermatol. 134:710–714. 1996. View Article : Google Scholar

25 

Viard-Leveugle I, Gaide O, Jankovic D, Feldmeyer L, Kerl K, Pickard C, Roques S, Friedmann PS, Contassot E and French LE: TNF-α and IFN-γ are potential inducers of Fas-mediated keratinocyte apoptosis through activation of inducible nitric oxide synthase in toxic epidermal necrolysis. J Invest Dermatol. 133:489–498. 2013. View Article : Google Scholar

26 

Lin YF, Yang CH, Sindy H, Lin JY, Hui Rosaline CY, Tsai YC, Wu TS, Huang CT, Kao KC, Hu HC, et al: Severe cutaneous adverse reactions related to systemic antibiotics. Clin Infect Dis. 58:1377–1385. 2014. View Article : Google Scholar

27 

Strom BL, Carson JL, Halpern AC, Schinnar R, Snyder ES, Shaw M, Tilson HH, Joseph M, Dai WS, Chen D, et al: A population-based study of Stevens-Johnson syndrome. Incidence and antecedent drug exposures. Arch Dermatol. 127:831–838. 1991. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ling X, Shi X and Chen L: Severe erythema multiforme‑type drug eruption controlled by tumor necrosis factor‑α antagonist: A case study. Exp Ther Med 14: 5727-5732, 2017.
APA
Ling, X., Shi, X., & Chen, L. (2017). Severe erythema multiforme‑type drug eruption controlled by tumor necrosis factor‑α antagonist: A case study. Experimental and Therapeutic Medicine, 14, 5727-5732. https://doi.org/10.3892/etm.2017.5336
MLA
Ling, X., Shi, X., Chen, L."Severe erythema multiforme‑type drug eruption controlled by tumor necrosis factor‑α antagonist: A case study". Experimental and Therapeutic Medicine 14.6 (2017): 5727-5732.
Chicago
Ling, X., Shi, X., Chen, L."Severe erythema multiforme‑type drug eruption controlled by tumor necrosis factor‑α antagonist: A case study". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5727-5732. https://doi.org/10.3892/etm.2017.5336
Copy and paste a formatted citation
x
Spandidos Publications style
Ling X, Shi X and Chen L: Severe erythema multiforme‑type drug eruption controlled by tumor necrosis factor‑α antagonist: A case study. Exp Ther Med 14: 5727-5732, 2017.
APA
Ling, X., Shi, X., & Chen, L. (2017). Severe erythema multiforme‑type drug eruption controlled by tumor necrosis factor‑α antagonist: A case study. Experimental and Therapeutic Medicine, 14, 5727-5732. https://doi.org/10.3892/etm.2017.5336
MLA
Ling, X., Shi, X., Chen, L."Severe erythema multiforme‑type drug eruption controlled by tumor necrosis factor‑α antagonist: A case study". Experimental and Therapeutic Medicine 14.6 (2017): 5727-5732.
Chicago
Ling, X., Shi, X., Chen, L."Severe erythema multiforme‑type drug eruption controlled by tumor necrosis factor‑α antagonist: A case study". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5727-5732. https://doi.org/10.3892/etm.2017.5336
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team