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Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential

  • Authors:
    • Xu Cheng
    • Lei Song
    • Min Lan
    • Bing Shi
    • Jingtao Li
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 247-253
    |
    Published online on: October 30, 2017
       https://doi.org/10.3892/etm.2017.5391
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Abstract

Tibialis anterior (TA) muscle and other somite‑derived limb muscles remain the prototype in skeletal muscle study. The majority of head muscles, however, develop from branchial arches and maintain a number of heterogeneities in comparison with their limb counterparts. Levator veli palatini (LVP) muscle is a deep‑located head muscle responsible for breathing, swallowing and speech, and is central to cleft palate surgery, yet lacks morphological and molecular investigation. In the present study, multiscale in vivo analyses were performed to compare TA and LVP muscle in terms of their myofiber composition, in‑situ stem cell population and augmentation potential. TA muscle was identified to be primarily composed of type 2B myofibers while LVP muscle primarily consisted of type 2A and 2X myofibers. In addition, LVP muscle maintained a higher percentage of centrally‑nucleated myofibers and a greater population of satellite cells. Notably, TA and LVP muscle responded to exogenous Wnt7a stimulus in different ways. Three weeks after Wnt7a administration, TA muscle exhibited an increase in myofiber number and a decrease in myofiber size, while LVP muscle demonstrated no significant changes in myofiber number or myofiber size. These results suggested that LVP muscle exhibits obvious differences in comparison with TA muscle. Therefore, knowledge acquired from TA muscle studies requires further testing before being applied to LVP muscle.
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1 

Randolph ME and Pavlath GK: A muscle stem cell for every muscle: Variability of satellite cell biology among different muscle groups. Front Aging Neurosci. 7:1902015. View Article : Google Scholar : PubMed/NCBI

2 

Sambasivan R, Kuratani S and Tajbakhsh S: An eye on the head: The development and evolution of craniofacial muscles. Development. 138:2401–2415. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Diogo R, Kelly RG, Christiaen L, Levine M, Ziermann JM, Molnar JL, Noden DM and Tzahor E: A new heart for a new head in vertebrate cardiopharyngeal evolution. Nature. 520:466–473. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Kelly RG: Core issues in craniofacial myogenesis. Exp Cell Res. 316:3034–3041. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Michailovici I, Eigler T and Tzahor E: Craniofacial muscle development. Curr Top Dev Biol. 115:3–30. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Shih HP, Gross MK and Kioussi C: Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch. Proc Natl Acad Sci USA. 104:pp. 5907–5912. 2007; View Article : Google Scholar : PubMed/NCBI

7 

Grifone R and Kelly RG: Heartening news for head muscle development. Trends Genet. 23:365–369. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Tzahor E and Evans SM: Pharyngeal mesoderm development during embryogenesis: Implications for both heart and head myogenesis. Cardiovasc Res. 91:196–202. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Pavlath GK, Thaloor D, Rando TA, Cheong M, English AW and Zheng B: Heterogeneity among muscle precursor cells in adult skeletal muscles with differing regenerative capacities. Dev Dyn. 212:495–508. 1998. View Article : Google Scholar : PubMed/NCBI

10 

von Maltzahn J, Bentzinger CF and Rudnicki MA: Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle. Nat Cell Biol. 14:186–191. 2012. View Article : Google Scholar

11 

Stuelsatz P, Shearer A, Li Y, Muir LA, Ieronimakis N, Shen QW, Kirillova I and Yablonka-Reuveni Z: Extraocular muscle satellite cells are high performance myo-engines retaining efficient regenerative capacity in dystrophin deficiency. Dev Biol. 397:31–44. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Fisher DM and Sommerlad BC: Cleft lip, cleft palate, and velopharyngeal insufficiency. Plast Reconstr Surg. 128:342e–360e. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Cohen SR, Chen L, Trotman CA and Burdi AR: Soft-palate myogenesis: A developmental field paradigm. Cleft Palate Craniofac J. 30:441–446. 1993. View Article : Google Scholar : PubMed/NCBI

14 

Koch KH, Grzonka MA and Koch J: The pathology of the velopharyngeal musculature in cleft palates. Ann Anat. 181:123–136. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Monroy PL Carvajal, Grefte S, Kuijpers-Jagtman AM, Wagener FA and Von den Hoff JW: Strategies to improve regeneration of the soft palate muscles after cleft palate repair. Tissue Eng Part B Rev. 18:468–477. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Iwata J, Suzuki A, Yokota T, Ho TV, Pelikan R, Urata M, Sanchez-Lara PA and Chai Y: TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate. Development. 141:909–917. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Crockett DJ and Goudy SL: Update on surgery for velopharyngeal dysfunction. Curr Opin Otolaryngol Head Neck Surg. 22:267–275. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Chakravarthy MV, Bradley SD and Frank WB: IGF-1 restores satellite cell proliferation potential in immobilized old skeletal muscle. J Appl Physiol (1985). 89:1365–1379. 2000.PubMed/NCBI

19 

Márquez-Miranda V, Abrigo J, Rivera JC, Araya-Durán I, Aravena J, Simon F, Pacheco N, González-Nilo FD and Cabello-Verrugio C: The complex of PAMAM-OH dendrimer with Angiotensin (1–7) prevented the disuse-induced skeletal muscle atrophy in mice. Int J Nanomedicine. 12:1985–1999. 2017. View Article : Google Scholar : PubMed/NCBI

20 

White RB, Bierinx AS, Gnocchi VF and Zammit PS: Dynamics of muscle fibre growth during postnatal mouse development. BMC Dev Biol. 10:212010. View Article : Google Scholar : PubMed/NCBI

21 

Monroy PL Carvajal, Grefte S, Kuijpers-Jagtman AM, Helmich MP, Ulrich DJ, Von den Hoff JW and Wagener FA: A rat model for muscle regeneration in the soft palate. PLoS One. 8:e591932013. View Article : Google Scholar : PubMed/NCBI

22 

Meng H, Janssen PM, Grange RW, Yang L, Beggs AH, Swanson LC, Cossette SA, Frase A, Childers MK, Granzier H, et al: Tissue triage and freezing for models of skeletal muscle disease. J Vis Exp. 2014. View Article : Google Scholar

23 

Chang NC and Rudnicki MA: Satellite cells: The architects of skeletal muscle. Curr Top Dev Biol. 107:161–181. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Cadot B, Gache V and Gomes ER: Moving and positioning the nucleus in skeletal muscle-one step at a time. Nucleus. 6:373–381. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Dumont NA, Bentzinger CF, Sincennes MC and Rudnicki MA: Satellite cells and skeletal muscle regeneration. Compr Physiol. 5:1027–1059. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Huraskin D, Eiber N, Reichel M, Zidek LM, Kravic B, Bernkopf D, von Maltzahn J, Behrens J and Hashemolhosseini S: Wnt/β-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers. Development. 143:3128–3142. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Le Grand F, Jones AE, Seale V, Scimè A and Rudnicki MA: Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell. 4:535–547. 2009. View Article : Google Scholar : PubMed/NCBI

28 

von Maltzahn J, Renaud JM, Parise G and Rudnicki MA: Wnt7a treatment ameliorates muscular dystrophy. Proc Natl Acad Sci USA. 109:pp. 20614–20619. 2012; View Article : Google Scholar : PubMed/NCBI

29 

Schiaffino S and Reggiani C: Fiber types in mammalian skeletal muscles. Physiol Rev. 91:1447–1531. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Perry JL, Kuehn DP and Sutton BP: Morphology of the levator veli palatini muscle using magnetic resonance imaging. Cleft Palate Craniofac J. 50:64–75. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Lindman R, Paulin G and Stål PS: Morphological Characterization of the levator veli palatini muscle in children born with cleft palates. Cleft Palate Craniofac J. 38:438–448. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Talbot J and Maves L: Skeletal muscle fiber type: Using insights from muscle developmental biology to dissect targets for susceptibility and resistance to muscle disease. Wiley Interdiscip Rev Dev Biol. 5:518–534. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Yin H, Price F and Rudnicki MA: Satellite cells and the muscle stem cell niche. Physiol Rev. 93:23–67. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Randolph ME, Phillips BL, Choo HJ, Vest KE, Vera Y and Pavlath GK: Pharyngeal satellite cells undergo myogenesis under basal conditions and are required for pharyngeal muscle maintenance. Stem Cells. 33:3581–3595. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Keefe AC, Lawson JA, Flygare SD, Fox ZD, Colasanto MP, Mathew SJ, Yandell M and Kardon G: Muscle stem cells contribute to myofibres in sedentary adult mice. Nat Commun. 6:70872015. View Article : Google Scholar : PubMed/NCBI

36 

Tamaki T, Akatsuka A, Yorshimura S, Roy RR and Edgerton VR: New fiber formation in the interstitial spacs of rat skeletal muscle during postnatal growth. J Histochem Cytochem. 50:1097–1111. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cheng X, Song L, Lan M, Shi B and Li J: Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential. Exp Ther Med 15: 247-253, 2018.
APA
Cheng, X., Song, L., Lan, M., Shi, B., & Li, J. (2018). Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential. Experimental and Therapeutic Medicine, 15, 247-253. https://doi.org/10.3892/etm.2017.5391
MLA
Cheng, X., Song, L., Lan, M., Shi, B., Li, J."Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential". Experimental and Therapeutic Medicine 15.1 (2018): 247-253.
Chicago
Cheng, X., Song, L., Lan, M., Shi, B., Li, J."Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential". Experimental and Therapeutic Medicine 15, no. 1 (2018): 247-253. https://doi.org/10.3892/etm.2017.5391
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng X, Song L, Lan M, Shi B and Li J: Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential. Exp Ther Med 15: 247-253, 2018.
APA
Cheng, X., Song, L., Lan, M., Shi, B., & Li, J. (2018). Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential. Experimental and Therapeutic Medicine, 15, 247-253. https://doi.org/10.3892/etm.2017.5391
MLA
Cheng, X., Song, L., Lan, M., Shi, B., Li, J."Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential". Experimental and Therapeutic Medicine 15.1 (2018): 247-253.
Chicago
Cheng, X., Song, L., Lan, M., Shi, B., Li, J."Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential". Experimental and Therapeutic Medicine 15, no. 1 (2018): 247-253. https://doi.org/10.3892/etm.2017.5391
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