Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2018 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Analysis of the clinical value of fractional flow reserve for prognosis evaluation of patients of percutaneous coronary intervention

  • Authors:
    • Qingxia Zhao
    • Zheng Ji
    • Xia Li
    • Yali Di
    • Haojun An
    • Bin Wei
    • Liming Yang
    • Wensheng Chen
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Tangshan Workers' Hospital, Tangshan, Hebei 063000, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 673-678
    |
    Published online on: November 1, 2017
       https://doi.org/10.3892/etm.2017.5433
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

We investigated the clinical value of fractional flow reserve (FFR) for the prognostic evaluation of patients with percutaneous coronary intervention. We enrolled 120 patients who were admitted to the hospital to undergo percutaneous coronary intervention for acute coronary syndromes between May 2014 and June 2015. The 120 patients were divided into two groups, the observation group and the control group, according to the post-surgery level of FFR. Each cohort contained 60 patients. These patients were divided into the occurrence group (n=45) and the non-occurrence group (n=75), classified according to the occurrence of major adverse cardiovascular events (MACE). There were no statistically significant differences in the comparison of the occurrence rate of MACE within 30 days after surgery, such as lethal or non-lethal myocardial infarction or non-lethal cerebrovascular events, between the observational group and the control group (P>0.05). For the observation group, the 1-year survival cases were 56 with a survival rate of 93.3%, and 2-year survival cases were 50 with a survival rate of 83.3%. In the control group, the 1-year and 2-year survival cases were respectively 55 and 49 (survival rate of 91.7 and 81.7%). The occurrence rates of hyperlipidemia and ratio of patients with a history of smoking and drinking in the occurrence group were significantly higher than those in the non-occurrence group (P<0.05). The mean arterial pressure in the occurrence group was significantly higher than that in the non-occurrence group (P<0.05). Heart rate in the occurrence group is significantly faster than that in the non-occurrence group (P<0.05) and the stenosis degree in the occurrence group was significantly higher than that in the non-occurrence group (P<0.05). The left ventricular ejection fraction (LVEF) before surgery in the occurrence group was significantly lower than that in the non-occurrence group (P<0.05). There were no remarkable differences in comparison of the pre-treatment FFR between the occurrence group and the non-occurrence group (P>0.05), but the post-treatment FFR in the occurrence group was significantly lower than that in the non-occurrence group (P<0.05). Increased blood fat, a history of smoking and drinking, augmented mean arterial pressure, accelerated heart rate, severe coronary artery stenosis and the remarkably decreased LVEF were all identified as independent risk factors leading to major adverse myocardial events. The sum of specificity and sensitivity of treatment reached the peak when the post-surgery FFR was 0.875, the calculated sensitivity was 82.4%, and the specificity was 50.8%. In conclusion, measurement of FFR after percutaneous coronary intervention could not only effectively evaluate the target vessel revascularization, but also predict the occurrence of major adverse myocardial events 1 year after surgery, which could serve as the guidance for clinical treatment.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Park SH, Jeon KH, Lee JM, Nam CW, Doh JH, Lee BK, Rha SW, Yoo KD, Jung KT, Cho YS, et al: Long-term clinical outcomes of fractional flow reserve-guided versus routine drug-eluting stent implantation in patients with intermediate coronary stenosis: five-year clinical outcomes of DEFER-DES trial. Circ Cardiovasc Interv. 8:e0024422015. View Article : Google Scholar : PubMed/NCBI

2 

Maehara A, Ben-Yehuda O, Ali Z, Wijns W, Bezerra HG, Shite J, Généreux P, Nichols M, Jenkins P, Witzenbichler B, et al: Comparison of stent expansion guided by optical coherence tomography versus intravascular ultrasound: the ILUMIEN II study (observational study of optical coherence tomography [OCT] in patients undergoing fractional flow reserve [FFR] and percutaneous coronary intervention). JACC Cardiovasc Interv. 8:1704–1714. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Vos NS, van der Schaaf RJ, Amoroso G, Herrman JP, Patterson MS, Slagboom T and Vink MA: REVascularization with paclitaxEL-coated balloon angioplasty versus drug-eluting stenting in acute myocardial infarcTION-a randomized controlled trial: rationale and design of the REVELATION trial. Catheter Cardiovasc Interv. 87:1213–1221. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Cho S, Kim JS, Ha J, Shin DH, Kim BK, Ko YG, Choi D, Jang Y and Hong MK: Three-dimensional optical coherence tomographic analysis of eccentric morphology of the jailed side-branch ostium in coronary bifurcation lesions. Can J Cardiol. 32:234–239. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Doh JH, Nam CW, Koo BK, Park SH, Lee JH, Han JK, Yang HM, Lim HS, Yoon MH, Cho YK, et al: Long-term patient-related and lesion-related outcomes after real-world fractional flow reserve use. J Invasive Cardiol. 27:410–415. 2015.PubMed/NCBI

6 

De Maria GL, Cuculi F, Patel N, Dawkins S, Fahrni G, Kassimis G, Choudhury RP, Forfar JC, Prendergast BD, Channon KM, et al: How does coronary stent implantation impact on the status of the microcirculation during primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction? Eur Heart J. 36:1–3177. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Wijns W, Shite J, Jones MR, Lee SW, Price MJ, Fabbiocchi F, Barbato E, Akasaka T, Bezerra H and Holmes D: Optical coherence tomography imaging during percutaneous coronary intervention impacts physician decision-making: ILUMIEN I study. Eur Heart J. 36:3346–3355. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Kimura Y, Tanaka N, Okura H, Yoshida K, Akabane M, Takayama T, Hirayama A, Tada T, Kimura T, Takano H, et al: Characterization of real-world patients with low fractional flow reserve immediately after drug-eluting stents implantation. Cardiovasc Interv Ther. 31:29–37. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Reith S, Battermann S, Hellmich M, Marx N and Burgmaier M: Correlation between OCT-derived intrastent dimensions and fractional flow reserve measurements after coronary stent implantation and impact on clinical outcome. J Invasive Cardiol. 27:222–228. 2015.PubMed/NCBI

10 

Courand PY, Dementhon J, Rioufol G and Finet G: Very late neoatherosclerotic plaque rupture in drug-eluting stent restenosis. J Cardiovasc Med (Hagerstown). 16 Suppl 1:27–28. 2015. View Article : Google Scholar

11 

Ito T, Tani T, Fujita H and Ohte N: Relationship between fractional flow reserve and residual plaque volume and clinical outcomes after optimal drug-eluting stent implantation: insight from intravascular ultrasound volumetric analysis. Int J Cardiol. 176:399–404. 2014. View Article : Google Scholar : PubMed/NCBI

12 

McNeice AH, McAleavey NM and Menown IB: Advances in clinical cardiology. Adv Ther. 31:837–860. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Fröhlich GM, Redwood S, Rakhit R, MacCarthy PA, Lim P, Crake T, White SK, Knight CJ, Kustosz C, Knapp G, et al: Long-term survival in patients undergoing percutaneous interventions with or without intracoronary pressure wire guidance or intracoronary ultrasonographic imaging: a large cohort study. JAMA Intern Med. 174:1360–1366. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Varho V, Karjalainen PP, Ylitalo A, Airaksinen JK, Mikkelsson J, Sia J, Pietilä M and Kiviniemi TO: Transthoracic echocardiography for non-invasive assessment of coronary vasodilator function after DES implantation. Eur Heart J Cardiovasc Imaging. 15:1029–1034. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Dörr R, Stumpf J, Dalibor J, Simonis G and Spitzer SG: Percutaneous coronary intervention versus bypass surgery in patients with diabetes and multivessel coronary disease. Coronary revascularization after FREEDOM. Herz. 39:331–342. 2014.(In German).

16 

Onuma Y, Dudek D, Thuesen L, Webster M, Nieman K, Garcia-Garcia HM, Ormiston JA and Serruys PW: Five-year clinical and functional multislice computed tomography angiographic results after coronary implantation of the fully resorbable polymeric everolimus-eluting scaffold in patients with de novo coronary artery disease: the ABSORB cohort a trial. JACC Cardiovasc Interv. 6:999–1009. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Park SJ, Ahn JM, Park GM, Cho YR, Lee JY, Kim WJ, Han S, Kang SJ, Park DW, Lee SW, et al: Trends in the outcomes of percutaneous coronary intervention with the routine incorporation of fractional flow reserve in real practice. Eur Heart J. 34:3353–3361. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Rao VU, Pavlov A, Klearman M, Musselman D, Giles JT, Bathon JM, Sattar N and Lee JS: An evaluation of risk factors for major adverse cardiovascular events during tocilizumab therapy. Arthritis Rheumatol. 67:372–380. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Matsuo A, Fujita H, Tanigaki T, Shimonaga T, Ueoka A, Tsubakimoto Y, Sakatani T, Kimura S, Inoue K and Kitamura M: Clinical implications of coronary pressure measurement after stent implantation. Cardiovasc Interv Ther. 28:170–177. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Corban MT, Eshtehardi P and Samady H: Fractional flow reserve for the assessment of complex multivessel disease in a patient after hybrid coronary revascularization. Catheter Cardiovasc Interv. 81:1169–1173. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao Q, Ji Z, Li X, Di Y, An H, Wei B, Yang L and Chen W: Analysis of the clinical value of fractional flow reserve for prognosis evaluation of patients of percutaneous coronary intervention. Exp Ther Med 15: 673-678, 2018.
APA
Zhao, Q., Ji, Z., Li, X., Di, Y., An, H., Wei, B. ... Chen, W. (2018). Analysis of the clinical value of fractional flow reserve for prognosis evaluation of patients of percutaneous coronary intervention. Experimental and Therapeutic Medicine, 15, 673-678. https://doi.org/10.3892/etm.2017.5433
MLA
Zhao, Q., Ji, Z., Li, X., Di, Y., An, H., Wei, B., Yang, L., Chen, W."Analysis of the clinical value of fractional flow reserve for prognosis evaluation of patients of percutaneous coronary intervention". Experimental and Therapeutic Medicine 15.1 (2018): 673-678.
Chicago
Zhao, Q., Ji, Z., Li, X., Di, Y., An, H., Wei, B., Yang, L., Chen, W."Analysis of the clinical value of fractional flow reserve for prognosis evaluation of patients of percutaneous coronary intervention". Experimental and Therapeutic Medicine 15, no. 1 (2018): 673-678. https://doi.org/10.3892/etm.2017.5433
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Q, Ji Z, Li X, Di Y, An H, Wei B, Yang L and Chen W: Analysis of the clinical value of fractional flow reserve for prognosis evaluation of patients of percutaneous coronary intervention. Exp Ther Med 15: 673-678, 2018.
APA
Zhao, Q., Ji, Z., Li, X., Di, Y., An, H., Wei, B. ... Chen, W. (2018). Analysis of the clinical value of fractional flow reserve for prognosis evaluation of patients of percutaneous coronary intervention. Experimental and Therapeutic Medicine, 15, 673-678. https://doi.org/10.3892/etm.2017.5433
MLA
Zhao, Q., Ji, Z., Li, X., Di, Y., An, H., Wei, B., Yang, L., Chen, W."Analysis of the clinical value of fractional flow reserve for prognosis evaluation of patients of percutaneous coronary intervention". Experimental and Therapeutic Medicine 15.1 (2018): 673-678.
Chicago
Zhao, Q., Ji, Z., Li, X., Di, Y., An, H., Wei, B., Yang, L., Chen, W."Analysis of the clinical value of fractional flow reserve for prognosis evaluation of patients of percutaneous coronary intervention". Experimental and Therapeutic Medicine 15, no. 1 (2018): 673-678. https://doi.org/10.3892/etm.2017.5433
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team