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Identifying pathway modules of tuberculosis in children by analyzing multiple different networks

  • Authors:
    • Lu Cheng
    • Yuling Han
    • Xiuxia Zhao
    • Xiaoli Xu
    • Jing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 755-760
    |
    Published online on: November 2, 2017
       https://doi.org/10.3892/etm.2017.5434
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Abstract

Tuberculosis (TB), which is caused by the mycobacterium TB, is the major cause of human death worldwide. The aim of this study was to identify the biomarkers involved in child TB. Gene expression data were obtained from the Array Express Archive of Functional Genomics Data. Gene expression data and protein-protein interaction (PPI) data were downloaded to construct differential gene co-expression networks (DCNs). The Benjamini-Hochberg algorithm was used to correct the P-value. In total, 3,820 edges (PPIs) and 1,359 nodes (genes) were obtained from the human-related PPIs data and gene expression data at the criteria of absolute value of Pearson's correlation coefficient >0.8. The DCNs were formed by these edges and nodes. Thirteen seed genes were obtained by ranging z-scores. Eight significant multiple different modules were identified from DCNs using the statistical significant test. In conclusion, the seed genes and significant modules constitute potential biomarkers that reveal the underlying mechanisms in child TB. The new identified biomarkers may contribute to an understanding of TB and provide a new therapeutic method for the treatment of TB.
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1 

Rawat J, Sindhwani G and Juyal R: Clinico-radiological profile of new smear positive pulmonary tuberculosis cases among young adult and elderly people in a tertiary care hospital at Deheradun (Uttarakhand). Indian J Tuberc. 55:84–90. 2008.PubMed/NCBI

2 

Starke JR: Resurgence of tuberculosis in children. Pediatr Pulmonol Suppl. 11:16–17. 1995. View Article : Google Scholar : PubMed/NCBI

3 

Smith S, Jacobs RF and Wilson CB: Immunobiology of childhood tuberculosis: A window on the ontogeny of cellular immunity. J Pediatr. 131:16–26. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Yoo AS, Staahl BT, Chen L and Crabtree GR: MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature. 460:642–646. 2009.PubMed/NCBI

5 

World Health Organisation (WHO), . Global health observatory data. 2017, http://www.who.int/gho/hiv/en/

6 

Hamilton CD, Swaminathan S, Christopher DJ, Ellner J, Gupta A, Sterling TR, Rolla V, Srinivasan S, Karyana M, Siddiqui S, et al: RePORT International: Advancing tuberculosis biomarker research through global collaboration. Clin Infect Dis. 61:155–159. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Trunz BB, Fine P and Dye C: Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: A meta-analysis and assessment of cost-effectiveness. Lancet. 367:1173–1180. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Zar HJ, Workman L, Isaacs W, Dheda K, Zemanay W and Nicol MP: Rapid diagnosis of pulmonary tuberculosis in African children in a primary care setting by use of Xpert MTB/RIF on respiratory specimens: A prospective study. Lancet Glob Health. 1:97–104. 2013. View Article : Google Scholar

9 

Gous N, Scott LE, Khan S, Reubenson G, Coovadia A and Stevens W: Diagnosing childhood pulmonary tuberculosis using a single sputum specimen on Xpert MTB/RIF at point of care. S Afr Med J. 105:1044–1048. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Fiebig L, Hauer B, Brodhun B, Balabanova Y and Haas W: Bacteriological confirmation of pulmonary tuberculosis in children with gastric aspirates in Germany, 2002–2010. Int J Tuberc Lung Dis. 18:925–930. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, et al: A human protein-protein interaction network: A resource for annotating the proteome. Cell. 122:957–968. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Ferrari R, Forabosco P, Vandrovcova J, Botía JA, Guelfi S, Warren JD, Momeni P, Weale ME, Ryten M and Hardy J: UK Brain Expression Consortium (UKBEC): Frontotemporal dementia: Insights into the biological underpinnings of disease through gene co-expression network analysis. Mol Neurodegener. 11:212016. View Article : Google Scholar : PubMed/NCBI

13 

Safaei A, Rezaei Tavirani M, Arefi Oskouei A, Zamanian Azodi M, Mohebbi SR and Nikzamir AR: Protein-protein interaction network analysis of cirrhosis liver disease. Gastroenterol Hepatol Bed Bench. 9:114–123. 2016.PubMed/NCBI

14 

Jin N, Wu H, Miao Z, Huang Y, Hu Y, Bi X, Wu D, Qian K, Wang L, Wang C, et al: Network-based survival-associated module biomarker and its crosstalk with cell death genes in ovarian cancer. Sci Rep. 5:115662015. View Article : Google Scholar : PubMed/NCBI

15 

Ramadan E, Alinsaif S and Hassan MR: Network topology measures for identifying disease-gene association in breast cancer. BMC Bioinformatics. 17:2742016. View Article : Google Scholar : PubMed/NCBI

16 

Feser WJ, Fingerlin TE, Strand MJ and Glueck DH: Calculating Average Power for the Benjamini-Hochberg Procedure. J Stat Theory Appl. 8:325–352. 2009.PubMed/NCBI

17 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Ma X, Gao L, Karamanlidis G, Gao P, Lee CF, Garcia-Menendez L, Tian R and Tan K: Revealing pathway dynamics in heart diseases by analyzing multiple differential networks. PLOS Comput Biol. 11:e10043322015. View Article : Google Scholar : PubMed/NCBI

19 

Schwarz E, Izmailov R, Liò P and Meyer-Lindenberg A: Protein interaction networks link schizophrenia risk loci to synaptic function. Schizophr Bull. 42:1334–1342. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Kulshrestha A, Suman S and Ranjan R: Network analysis reveals potential markers for pediatric adrenocortical carcinoma. Onco Targets Ther. 9:4569–4581. 2016. View Article : Google Scholar : PubMed/NCBI

21 

de Bruijn DR, Kater-Baats E, Eleveld M, Merkx G and Geurts Van Kessel A: Mapping and characterization of the mouse and human SS18 genes, two human SS18-like genes and a mouse Ss18 pseudogene. Cytogenet Cell Genet. 92:310–319. 2001. View Article : Google Scholar : PubMed/NCBI

22 

de Bruijn DR, Allander SV, van Dijk AH, Willemse MP, Thijssen J, van Groningen JJ, Meltzer PS and van Kessel AG: The synovial-sarcoma-associated SS18-SSX2 fusion protein induces epigenetic gene (de)regulation. Cancer Res. 66:9474–9482. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Freed EF, Prieto JL, McCann KL, McStay B and Baserga SJ: NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing. PLoS Genet. 8:e10028922012. View Article : Google Scholar : PubMed/NCBI

24 

Kmoch S, Hartmannová H, Stibůrková B, Krijt J, Zikánová M and Sebesta I: Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure and molecular basis for ADSL deficiency in six patients. Hum Mol Genet. 9:1501–1513. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Stone RL, Aimi J, Barshop BA, Jaeken J, van den Berghe G, Zalkin H and Dixon JE: A mutation in adenylosuccinate lyase associated with mental retardation and autistic features. Nat Genet. 1:59–63. 1992. View Article : Google Scholar : PubMed/NCBI

26 

Fon EA, Demczuk S, Delattre O, Thomas G and Rouleau GA: Mapping of the human adenylosuccinate lyase (ADSL) gene to chromosome 22q13.1->q13.2. Cytogenet Cell Genet. 64:201–203. 1993. View Article : Google Scholar : PubMed/NCBI

27 

Rigo F, Hua Y, Chun SJ, Prakash TP, Krainer AR and Bennett CF: Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing. Nat Chem Biol. 8:555–561. 2012. View Article : Google Scholar : PubMed/NCBI

28 

López-Fernández LA, Párraga M and del Mazo J: Ilf2 is regulated during meiosis and associated to transcriptionally active chromatin. Mech Dev. 111:153–157. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N and Shiekhattar R: The microprocessor complex mediates the genesis of microRNAs. Nature. 432:235–240. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Han C, Liu Y, Wan G, Choi HJ, Zhao L, Ivan C, He X, Sood AK, Zhang X and Lu X: The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression. Cell Reports. 8:1447–1460. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cheng L, Han Y, Zhao X, Xu X and Wang J: Identifying pathway modules of tuberculosis in children by analyzing multiple different networks. Exp Ther Med 15: 755-760, 2018.
APA
Cheng, L., Han, Y., Zhao, X., Xu, X., & Wang, J. (2018). Identifying pathway modules of tuberculosis in children by analyzing multiple different networks. Experimental and Therapeutic Medicine, 15, 755-760. https://doi.org/10.3892/etm.2017.5434
MLA
Cheng, L., Han, Y., Zhao, X., Xu, X., Wang, J."Identifying pathway modules of tuberculosis in children by analyzing multiple different networks". Experimental and Therapeutic Medicine 15.1 (2018): 755-760.
Chicago
Cheng, L., Han, Y., Zhao, X., Xu, X., Wang, J."Identifying pathway modules of tuberculosis in children by analyzing multiple different networks". Experimental and Therapeutic Medicine 15, no. 1 (2018): 755-760. https://doi.org/10.3892/etm.2017.5434
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng L, Han Y, Zhao X, Xu X and Wang J: Identifying pathway modules of tuberculosis in children by analyzing multiple different networks. Exp Ther Med 15: 755-760, 2018.
APA
Cheng, L., Han, Y., Zhao, X., Xu, X., & Wang, J. (2018). Identifying pathway modules of tuberculosis in children by analyzing multiple different networks. Experimental and Therapeutic Medicine, 15, 755-760. https://doi.org/10.3892/etm.2017.5434
MLA
Cheng, L., Han, Y., Zhao, X., Xu, X., Wang, J."Identifying pathway modules of tuberculosis in children by analyzing multiple different networks". Experimental and Therapeutic Medicine 15.1 (2018): 755-760.
Chicago
Cheng, L., Han, Y., Zhao, X., Xu, X., Wang, J."Identifying pathway modules of tuberculosis in children by analyzing multiple different networks". Experimental and Therapeutic Medicine 15, no. 1 (2018): 755-760. https://doi.org/10.3892/etm.2017.5434
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