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Aripiprazole exerts a neuroprotective effect in mouse focal cerebral ischemia

  • Authors:
    • Chan H. Gil
    • Yu R. Kim
    • Hong J. Lee
    • Da H. Jung
    • Hwa K. Shin
    • Byung T. Choi
  • View Affiliations / Copyright

    Affiliations: Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Gyeongsangnam 50612, Republic of Korea
    Copyright: © Gil et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 745-750
    |
    Published online on: November 6, 2017
       https://doi.org/10.3892/etm.2017.5443
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Abstract

Previous studies have demonstrated that aripiprazole (APZ), a third‑generation atypical antipsychotic drug, exhibits anti‑depressant and neuroprotective effects by promoting dopaminergic neuronal cell recovery in stroke. To investigate the neuroprotective effects of APZ, behavioral and histopathological experiments were performed in the current study a mouse model of middle cerebral artery occlusion (MCAO)‑induced ischemia following administration of APZ. The subacute phase of ischemic assaults was divided into 3 periods, each with a duration of 5 days, according to the start of APZ (3 mg/kg) administration (1‑5, 5‑9 or 10‑14 days following MCAO). The beneficial effects of APZ on motor behavior demonstrated in the cylinder, rotarod and wire suspension tests were greatest when APZ was administered 1‑5 days following MCAO, with clear improvements in motor function compared with vehicle‑treated mice. Histopathological analysis revealed that prominent atrophic changes occurred in the striatum of MCAO mice and that these changes were reduced following APZ treatment. APZ also attenuated dopaminergic neuronal injury in the striatum. Cell death and microglial activation were decreased and the expression of Ca2+/calmodulin‑dependent protein kinase II δ was enhanced following APZ treatment. These results indicate that the atypical antipsychotic drug, APZ, exhibits a neuroprotective effect in dopaminergic neuronal cells that may improve behavioral function following ischemic stroke.
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Copy and paste a formatted citation
Spandidos Publications style
Gil CH, Kim YR, Lee HJ, Jung DH, Shin HK and Choi BT: Aripiprazole exerts a neuroprotective effect in mouse focal cerebral ischemia. Exp Ther Med 15: 745-750, 2018.
APA
Gil, C.H., Kim, Y.R., Lee, H.J., Jung, D.H., Shin, H.K., & Choi, B.T. (2018). Aripiprazole exerts a neuroprotective effect in mouse focal cerebral ischemia. Experimental and Therapeutic Medicine, 15, 745-750. https://doi.org/10.3892/etm.2017.5443
MLA
Gil, C. H., Kim, Y. R., Lee, H. J., Jung, D. H., Shin, H. K., Choi, B. T."Aripiprazole exerts a neuroprotective effect in mouse focal cerebral ischemia". Experimental and Therapeutic Medicine 15.1 (2018): 745-750.
Chicago
Gil, C. H., Kim, Y. R., Lee, H. J., Jung, D. H., Shin, H. K., Choi, B. T."Aripiprazole exerts a neuroprotective effect in mouse focal cerebral ischemia". Experimental and Therapeutic Medicine 15, no. 1 (2018): 745-750. https://doi.org/10.3892/etm.2017.5443
Copy and paste a formatted citation
x
Spandidos Publications style
Gil CH, Kim YR, Lee HJ, Jung DH, Shin HK and Choi BT: Aripiprazole exerts a neuroprotective effect in mouse focal cerebral ischemia. Exp Ther Med 15: 745-750, 2018.
APA
Gil, C.H., Kim, Y.R., Lee, H.J., Jung, D.H., Shin, H.K., & Choi, B.T. (2018). Aripiprazole exerts a neuroprotective effect in mouse focal cerebral ischemia. Experimental and Therapeutic Medicine, 15, 745-750. https://doi.org/10.3892/etm.2017.5443
MLA
Gil, C. H., Kim, Y. R., Lee, H. J., Jung, D. H., Shin, H. K., Choi, B. T."Aripiprazole exerts a neuroprotective effect in mouse focal cerebral ischemia". Experimental and Therapeutic Medicine 15.1 (2018): 745-750.
Chicago
Gil, C. H., Kim, Y. R., Lee, H. J., Jung, D. H., Shin, H. K., Choi, B. T."Aripiprazole exerts a neuroprotective effect in mouse focal cerebral ischemia". Experimental and Therapeutic Medicine 15, no. 1 (2018): 745-750. https://doi.org/10.3892/etm.2017.5443
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