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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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February-2018 Volume 15 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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PTX3 in serum induces renal mesangial cell proliferation but has no effect on apoptosis

  • Authors:
    • Danhuan Zhang
    • Minhui Xi
    • Lingyun Chen
    • Yanping Huang
    • Peiju Mao

  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Tongren Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200336, P.R. China, Department of Nephrology, Pudong New Area People's Hospital, Shanghai 201200, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1193-1198
    |
    Published online on: November 16, 2017
       https://doi.org/10.3892/etm.2017.5521
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Abstract

The present study aimed to investigate the effect of pentraxin 3 (PTX3) on the regulation of proliferation and apoptosis in human glomerular mesangial cells (HMCs). Small interfering (si)RNA was designed and synthesized to inhibit the expression of endogenous PTX3, and the effects on the proliferation and apoptosis of HMCs were detected by flow cytometry and an MTT assay. Western blot analysis was used to detect the activation of mitogen‑activated protein kinase (MAPK) proteins in HMCs with PTX3 knockdown. Three siRNAs targeting PTX3 were individually transfected into HMCs for 48 h, and reverse‑transcription quantitative PCR demonstrated that the relative mRNA expression of PTX3 was significantly decreased in all groups by up to 79.62% of that in the control group (P<0.05). Following transfection with PTX3‑siRNA, the viability of an HMC line was significantly decreased in comparison with that of a control group transfected with scrambled siRNA. However, PTX3‑siRNA did not significantly effect early and late apoptotic cell populations in HMCs compared with those in the control. Endogenous PTX3 interference was found to significantly decrease p38 MAPK, extracellular signal‑regulated kinase 1/2 and c‑Jun N‑terminal kinase phosphorylation. In conclusion, silencing of PTX3, inhibited the proliferation of HMCs via MAPK pathways, but exerted no effect on the apoptosis of HMCs.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang D, Xi M, Chen L, Huang Y and Mao P: PTX3 in serum induces renal mesangial cell proliferation but has no effect on apoptosis. Exp Ther Med 15: 1193-1198, 2018.
APA
Zhang, D., Xi, M., Chen, L., Huang, Y., & Mao, P. (2018). PTX3 in serum induces renal mesangial cell proliferation but has no effect on apoptosis. Experimental and Therapeutic Medicine, 15, 1193-1198. https://doi.org/10.3892/etm.2017.5521
MLA
Zhang, D., Xi, M., Chen, L., Huang, Y., Mao, P."PTX3 in serum induces renal mesangial cell proliferation but has no effect on apoptosis". Experimental and Therapeutic Medicine 15.2 (2018): 1193-1198.
Chicago
Zhang, D., Xi, M., Chen, L., Huang, Y., Mao, P."PTX3 in serum induces renal mesangial cell proliferation but has no effect on apoptosis". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1193-1198. https://doi.org/10.3892/etm.2017.5521
Copy and paste a formatted citation
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Spandidos Publications style
Zhang D, Xi M, Chen L, Huang Y and Mao P: PTX3 in serum induces renal mesangial cell proliferation but has no effect on apoptosis. Exp Ther Med 15: 1193-1198, 2018.
APA
Zhang, D., Xi, M., Chen, L., Huang, Y., & Mao, P. (2018). PTX3 in serum induces renal mesangial cell proliferation but has no effect on apoptosis. Experimental and Therapeutic Medicine, 15, 1193-1198. https://doi.org/10.3892/etm.2017.5521
MLA
Zhang, D., Xi, M., Chen, L., Huang, Y., Mao, P."PTX3 in serum induces renal mesangial cell proliferation but has no effect on apoptosis". Experimental and Therapeutic Medicine 15.2 (2018): 1193-1198.
Chicago
Zhang, D., Xi, M., Chen, L., Huang, Y., Mao, P."PTX3 in serum induces renal mesangial cell proliferation but has no effect on apoptosis". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1193-1198. https://doi.org/10.3892/etm.2017.5521
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