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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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February-2018 Volume 15 Issue 2

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International Journal of Molecular Medicine

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Identification of core pathways based on attractor and crosstalk in ischemic stroke

  • Authors:
    • Xiufang Diao
    • Aijuan Liu

  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of Cardiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
    Copyright: © Diao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1520-1524
    |
    Published online on: November 24, 2017
       https://doi.org/10.3892/etm.2017.5563
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Abstract

Ischemic stroke is a leading cause of mortality and disability around the world. It is an important task to identify dysregulated pathways which infer molecular and functional insights existing in high‑throughput experimental data. Gene expression profile of E-GEOD-16561 was collected. Pathways were obtained from the database of Kyoto Encyclopedia of Genes and Genomes and Retrieval of Interacting Genes was used to download protein-protein interaction sets. Attractor and crosstalk approaches were applied to screen dysregulated pathways. A total of 20 differentially expressed genes were identified in ischemic stroke. Thirty-nine significant differential pathways were identified according to P<0.01 and 28 pathways were identified with RP<0.01 and 17 pathways were identified with impact factor >250. On the basis of the three criteria, 11 significant dysfunctional pathways were identified. Among them, Epstein-Barr virus infection was the most significant differential pathway. In conclusion, with the method based on attractor and crosstalk, significantly dysfunctional pathways were identified. These pathways are expected to provide molecular mechanism of ischemic stroke and represents a novel potential therapeutic target for ischemic stroke treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Diao X and Liu A: Identification of core pathways based on attractor and crosstalk in ischemic stroke. Exp Ther Med 15: 1520-1524, 2018.
APA
Diao, X., & Liu, A. (2018). Identification of core pathways based on attractor and crosstalk in ischemic stroke. Experimental and Therapeutic Medicine, 15, 1520-1524. https://doi.org/10.3892/etm.2017.5563
MLA
Diao, X., Liu, A."Identification of core pathways based on attractor and crosstalk in ischemic stroke". Experimental and Therapeutic Medicine 15.2 (2018): 1520-1524.
Chicago
Diao, X., Liu, A."Identification of core pathways based on attractor and crosstalk in ischemic stroke". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1520-1524. https://doi.org/10.3892/etm.2017.5563
Copy and paste a formatted citation
x
Spandidos Publications style
Diao X and Liu A: Identification of core pathways based on attractor and crosstalk in ischemic stroke. Exp Ther Med 15: 1520-1524, 2018.
APA
Diao, X., & Liu, A. (2018). Identification of core pathways based on attractor and crosstalk in ischemic stroke. Experimental and Therapeutic Medicine, 15, 1520-1524. https://doi.org/10.3892/etm.2017.5563
MLA
Diao, X., Liu, A."Identification of core pathways based on attractor and crosstalk in ischemic stroke". Experimental and Therapeutic Medicine 15.2 (2018): 1520-1524.
Chicago
Diao, X., Liu, A."Identification of core pathways based on attractor and crosstalk in ischemic stroke". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1520-1524. https://doi.org/10.3892/etm.2017.5563
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