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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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February-2018 Volume 15 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Gambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation, iNOS and NF‑κB/p38 pathway

  • Authors:
    • Duan Na
    • Hou Aijie
    • Luan Bo
    • Miao Zhilin
    • Yuan Long

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, Liaoning 110016, P.R. China
  • Pages: 1742-1748
    |
    Published online on: December 5, 2017
       https://doi.org/10.3892/etm.2017.5599
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Abstract

Gamboge, the dried resin secreted by Garcinia maingayii (gambogic tree), was previously demonstrated to exert anti‑inflammatory effects. The present study examined the effects of gambogic acid, the major active constituent of gamboge, on myocardial infarction (MI) and inflammation in a rat model and explored the possible underlying mechanisms. The results demonstrated that gambogic acid inhibited the ratio of heart weight to body weight and myocardial damage (via lactate dehydrogenase and cardiac troponin T) in rats with MI. Gambogic acid suppressed the activation of interleukin (IL)‑6 and tumor necrosis factor‑α, and increased IL‑10 levels in MI rats. Furthermore, gambogic acid reduced inducible nitric oxide synthase (iNOS), matrix metalloproteinase (MMP)‑2, MMP‑9, intercellular adhesion molecule‑1 (ICAM‑1), nuclear factor (NF)‑κB/p65 and phosphorylated p38 protein in ischemic myocardial tissue of MI rats. In conclusion, gambogic acid exerted anti‑inflammatory effects in MI rats by targeting the iNOS, MMPs, ICAM‑1, NF‑κB and p38 pathways. Gambogic acid may protect against MI‑induced inflammation in rats, which may be associated with the activation of the NF‑κB/p38 pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Na D, Aijie H, Bo L, Zhilin M and Long Y: Gambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation, iNOS and NF‑κB/p38 pathway. Exp Ther Med 15: 1742-1748, 2018.
APA
Na, D., Aijie, H., Bo, L., Zhilin, M., & Long, Y. (2018). Gambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation, iNOS and NF‑κB/p38 pathway. Experimental and Therapeutic Medicine, 15, 1742-1748. https://doi.org/10.3892/etm.2017.5599
MLA
Na, D., Aijie, H., Bo, L., Zhilin, M., Long, Y."Gambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation, iNOS and NF‑κB/p38 pathway". Experimental and Therapeutic Medicine 15.2 (2018): 1742-1748.
Chicago
Na, D., Aijie, H., Bo, L., Zhilin, M., Long, Y."Gambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation, iNOS and NF‑κB/p38 pathway". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1742-1748. https://doi.org/10.3892/etm.2017.5599
Copy and paste a formatted citation
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Spandidos Publications style
Na D, Aijie H, Bo L, Zhilin M and Long Y: Gambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation, iNOS and NF‑κB/p38 pathway. Exp Ther Med 15: 1742-1748, 2018.
APA
Na, D., Aijie, H., Bo, L., Zhilin, M., & Long, Y. (2018). Gambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation, iNOS and NF‑κB/p38 pathway. Experimental and Therapeutic Medicine, 15, 1742-1748. https://doi.org/10.3892/etm.2017.5599
MLA
Na, D., Aijie, H., Bo, L., Zhilin, M., Long, Y."Gambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation, iNOS and NF‑κB/p38 pathway". Experimental and Therapeutic Medicine 15.2 (2018): 1742-1748.
Chicago
Na, D., Aijie, H., Bo, L., Zhilin, M., Long, Y."Gambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation, iNOS and NF‑κB/p38 pathway". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1742-1748. https://doi.org/10.3892/etm.2017.5599
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