Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43 Corrigendum in /10.3892/etm.2018.6428

Li,Zhe; Zhang,Sha; Cao,Liang; Li,Wei; Ye,Yu‑Chen; Shi,Zi‑Xuan; Wang,Zong‑Ren; Sun,Lian‑Xu; Wang,Jia‑Wei; Jia,Lin‑Tao; Wang,Wen

doi:10.3892/etm.2017.5636

February-2018 Volume 15 Issue 2

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February-2018 Volume 15 Issue 2

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Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43

Corrigendum in: /10.3892/etm.2018.6428

Authors:
- Zhe Li
- Sha Zhang
- Liang Cao
- Wei Li
- Yu‑Chen Ye
- Zi‑Xuan Shi
- Zong‑Ren Wang
- Lian‑Xu Sun
- Jia‑Wei Wang
- Lin‑Tao Jia
- Wen Wang
View Affiliations / Copyright

Affiliations: Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Histology and Embryology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Acupuncture, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi 710003, P.R. China, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China

Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1847-1854
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Published online on: December 15, 2017

https://doi.org/10.3892/etm.2017.5636
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Abstract

Tanshinone IIA (Tan IIA) and Astragaloside IV (AGS‑IV) were used as therapeutic treatments for coronary heart diseases (CHDs) in ancient China. However, the underlying mechanisms mediating the effects of Tan IIA and AGS‑IV in angiogenesis remain unknown. In the present study, mesenchymal stem cells (MSCs) were induced to differentiate into endothelial cell (EC)‑like cells in vitro and the effects of Tan IIA and/or AGS‑IV on the functions of these cells, including cell proliferation and tube formation, were assessed. Compared with the single‑agent groups (Tan IIA or AGS‑IV only), combined‑agent (Tan IIA and AGS‑IV) treatment significantly enhanced the proliferation and tube formation capacity of EC‑like cells. In addition, the expression of connexin 37 (Cx37), Cx40 and Cx43 in the combined‑agent group was significantly increased compared with the single‑agent groups. Furthermore, enhanced gap junctional intercellular communication (GJIC) was identified in the combined‑agent group, as evidenced by increased dye transfer in scrape‑loading dye transfer assays. In conclusion, Tan IIA and AGS‑IV may promote the angiogenesis of EC‑like cells by upregulating the expression of Cx37, Cx40 and Cx43 and enhancing GJIC function. The results of the present study may provide experimental evidence for the clinical application of Tan IIA and AGS‑IV as a treatment for CHDs.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43

Corrigendum in: /10.3892/etm.2018.6428

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