Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2018 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Multiple brain abscesses caused by infection with Candida glabrata: A case report

  • Authors:
    • Zifeng Zhu
    • Zhehao Huang
    • Zhenshengnan Li
    • Xianglan Li
    • Chao Du
    • Yu Tian
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Clinical Medicine, Norman Bethune Health Science Center of Jilin University, Changchun, Jilin 130021, P.R. China, Laboratory of Fungus, Department of Dermatology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2374-2380
    |
    Published online on: January 4, 2018
       https://doi.org/10.3892/etm.2018.5692
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present case report described the initial diagnosis of a 25‑year old female with a brain abscess consisting of two lesions 0.2 and 2.9 cm3 in volume. The patient was initially treated with antibiotics; however, 2 months following initial treatment, the patient's condition deteriorated and she became vegetative. Following transfer to the China‑Japan Union Hospital of Jilin University (Jilin, China) the two lesions had grown in volume to 9.0 and 13.0 cm3, respectively. The results of magnetic resonance spectroscopy and plasma 1‑3‑β‑D‑glucan activity suggested a possible fungal infection. Subsequently, a stereotactic biopsy was conducted, fluid was cultured and itraconazole treatment was initiated. Analysis of cultures confirmed a Candida glabrata infection and antifungal treatment was continued. Shortly following surgery, the patient regained consciousness and the ability to eat and speak. A follow‑up MRI 8 months following biopsy confirmed disappearance of all lesions and no recurrence. To the best of our knowledge, this is the first English‑language report of a brain abscess caused primarily by Candida glabrata.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Raman Sharma R: Fungal infections of the nervous system: Current perspective and controversies in management. Int J Surg. 8:591–601. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Neves N, Santos L, Reis C and Sarmento A: Candida albicans brain abscesses in an injection drug user patient: A case report. BMC Res Notes. 7:8372014. View Article : Google Scholar : PubMed/NCBI

3 

Wang GH, Dai CL, Liu YF and Li YM: Cerebral and renal abscess and retino-choroiditis secondary to Candida albicans in preterm infants: Eight case retrospective study. Clin Exp Obstet Gynecol. 40:519–523. 2013.PubMed/NCBI

4 

Ancalle IM, Rivera JA, Garcia I, Garcia L and Valcárcel M: Candida albicans meningitis and brain abscesses in a neonate: A case report. Bol Asoc Med P R. 102:45–48. 2010.PubMed/NCBI

5 

Njambi S, Huttova M, Kovac M, Freybergh PF, Bauer F and Muli JM: Fungal neuroinfections: Rare disease but unacceptably high mortality. Neuro Endocrinol Lett. 28 Suppl 2:S25–S26. 2007.

6 

Prabhu RM and Orenstein R: Failure of caspofungin to treat brain abscesses secondary to Candida albicans prosthetic valve endocarditis. Clin Infect Dis. 39:1253–1254. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Marcinkowski M, Bauer K, Stoltenburg-Didinger G and Versmold H: Fungal brain abscesses in neonates: Sonographic appearances and corresponding histopathologic findings. J Clin Ultrasound. 29:417–421. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Gözdaşoĝlu S, Ertem M, Büyükkeçeci Z, Yavuzdemir S, Bengisun S, Ozenci H, Taçyildiz N, Unal E, Yavuz G, Deda G and Aysev D: Fungal colonization and infection in children with acute leukemia and lymphoma during induction therapy. Med Pediatr Oncol. 32:344–348. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Burgert SJ, Classen DC, Burke JP and Blatter DD: Candidal brain abscess associated with vascular invasion: A devastating complication of vascular catheter-related candidemia. Clin Infect Dis. 21:202–205. 1995. View Article : Google Scholar : PubMed/NCBI

10 

Kamitsuka MD, Nugent NA, Conrad PD and Swanson TN: Candida albicans brain abscesses in a premature infant treated with amphotericin B, flucytosine and fluconazole. Pediatr Infect Dis J. 14:329–331. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Radhakrishnan VV, Saraswathy A, Rout D and Mohan PK: Disseminated intra-cerebral microabscesses: A clinico-pathologic study. Indian J Pathol Microbiol. 37:171–178. 1994.PubMed/NCBI

12 

Pendlebury WW, Perl DP and Munoz DG: Multiple microabscesses in the central nervous system: A clinicopathologic study. J Neuropathol Exp Neurol. 48:290–300. 1989. View Article : Google Scholar : PubMed/NCBI

13 

Wiethölter H, Thron A, Scholz E and Dichgans J: Systemic Candida albicans infection with cerebral abscess and granulomas. Clin Neuropathol. 3:37–41. 1984.PubMed/NCBI

14 

Thron A and Wiethölter H: Cerebral candidiasis: CT studies in a case of brain abscess and granuloma due to Candida albicans. Neuroradiology. 23:223–225. 1982. View Article : Google Scholar : PubMed/NCBI

15 

Holyst J, Majewski A and Tyszkiewicz S: Massive cerebellar abscess due to Candida albicans. Neurochirurgia (Stuttg). 19:126–129. 1976.PubMed/NCBI

16 

Black JT: Cerebral candidiasis: Case report of brain abscess secondary to Candida albicans, and review of literature. J Neurol Neurosurg Psychiatry. 33:864–870. 1970. View Article : Google Scholar : PubMed/NCBI

17 

Bagheri F, Cervellione KL, Maruf M, Marino W and Santucci T Jr: Candida parapsilosis meningitis associated with shunt infection in an adult male. Clin Neurol Neurosurg. 112:248–251. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Andres RH, Guzman R, Weis J, Schroth G and Barth A: Granuloma formation and occlusion of an unruptured aneurysm after wrapping. Acta Neurochir (Wien). 149:953–958. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Lipton SA, Hickey WF, Morris JH and Loscalzo J: Candidal infection in the central nervous system. Am J Med. 76:101–108. 1984. View Article : Google Scholar : PubMed/NCBI

20 

Yoganathan S, Chakrabarty B, Gulati S, Kumar A, Kumar A, Singh M and Xess I: Candida tropicalis brain abscess in a neonate: An emerging nosocomial menace. Ann Indian Acad Neurol. 17:448–450. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Maschke M, Dietrich U, Prumbaum M, Kastrup O, Turowski B, Schaefer UW and Diener HC: Opportunistic CNS infection after bone marrow transplantation. Bone Marrow Transplant. 23:1167–1176. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Antunes NL, Hariharan S and DeAngelis LM: Brain abscesses in children with cancer. Med Pediatr Oncol. 31:19–21. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Schelenz S and Gransden WR: Candidaemia in a London teaching hospital: Analysis of 128 cases over a 7-year period. Mycoses. 46:390–396. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Hitchcock CA, Pye GW, Troke PF, Johnson EM and Warnock DW: Fluconazole resistance in Candida glabrata. Antimicrob Agents Chemother. 37:1962–1965. 1993. View Article : Google Scholar : PubMed/NCBI

25 

Komshian SV, Uwaydah AK, Sobel JD and Crane LR: Fungemia caused by Candida species and Torulopsis glabrata in the hospitalized patient: Frequency, characteristics, and evaluation of factors influencing outcome. Rev Infect Dis. 11:379–390. 1989. View Article : Google Scholar : PubMed/NCBI

26 

Willocks L, Leen CL, Brettle RP, Urquhart D, Russell TB and Milne LJ: Fluconazole resistance in AIDS patients. J Antimicrob Chemother. 28:937–939. 1991. View Article : Google Scholar : PubMed/NCBI

27 

Fidel PL Jr..Vazquez JA and Sobel JD: Candida glabrata: Review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clin Microbiol Rev. 12:80–96. 1999.PubMed/NCBI

28 

Selby R, Ramirez CB, Singh R, Kleopoulos I, Kusne S, Starzl TE and Fung J: Brain abscess in solid organ transplant recipients receiving cyclosporine-based immunosuppression. Arch Surg. 132:304–310. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Pham LV, Quang AT, Ton Nu PA, Duc TT and Thi HN: Cladophialophora bantiana and Candida albicans mixed infection in cerebral abscess of an HIV-negative patient. J Infect Dev Ctries. 2:245–248. 2008.PubMed/NCBI

30 

Hagensee ME, Bauwens JE, Kjos B and Bowden RA: Brain abscess following marrow transplantation: Experience at the Fred Hutchinson cancer research center, 1984–1992. Clin Infect Dis. 19:402–408. 1994. View Article : Google Scholar : PubMed/NCBI

31 

Sanchez-Portocarrero J, Pérez-Cecilia E, Corral O, Romero-Vivas J and Picazo JJ: The central nervous system and infection by Candida species. Diagn Microbiol Infect Dis. 37:169–179. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Larbcharoensub N, Wongwichai S, Chongtrakool P, Boongird A, Noinang A, Watcharananan SP, Tunlayadechanont S, Witoonpanich R and Phudhichareonrat S: Cerebral aspergillosis and cerebral candidiasis; a retrospective analysis of clinicopathologic features in Ramathibodi Hospital. J Med Assoc Thai. 93:1443–1450. 2010.PubMed/NCBI

33 

Fennelly AM, Slenker AK, Murphy LC, Moussouttas M and DeSimone JA: Candida cerebral abscesses: A case report and review of the literature. Med Mycol. 51:779–784. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Kaji M, Shoji H and Oizumi K: Intractable meningitis and intracranial abscess following sinusitis due to Candida species. Kurume Med J. 45:279–281. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Yampolsky C, Corti M and Negroni R: Fungal cerebral abscess in a diabetic patient successfully treated with surgery followed by prolonged antifungal therapy. Rev Iberoam Micol. 27:6–9. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu Z, Huang Z, Li Z, Li X, Du C and Tian Y: Multiple brain abscesses caused by infection with Candida glabrata: A case report. Exp Ther Med 15: 2374-2380, 2018.
APA
Zhu, Z., Huang, Z., Li, Z., Li, X., Du, C., & Tian, Y. (2018). Multiple brain abscesses caused by infection with Candida glabrata: A case report. Experimental and Therapeutic Medicine, 15, 2374-2380. https://doi.org/10.3892/etm.2018.5692
MLA
Zhu, Z., Huang, Z., Li, Z., Li, X., Du, C., Tian, Y."Multiple brain abscesses caused by infection with Candida glabrata: A case report". Experimental and Therapeutic Medicine 15.3 (2018): 2374-2380.
Chicago
Zhu, Z., Huang, Z., Li, Z., Li, X., Du, C., Tian, Y."Multiple brain abscesses caused by infection with Candida glabrata: A case report". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2374-2380. https://doi.org/10.3892/etm.2018.5692
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Z, Huang Z, Li Z, Li X, Du C and Tian Y: Multiple brain abscesses caused by infection with Candida glabrata: A case report. Exp Ther Med 15: 2374-2380, 2018.
APA
Zhu, Z., Huang, Z., Li, Z., Li, X., Du, C., & Tian, Y. (2018). Multiple brain abscesses caused by infection with Candida glabrata: A case report. Experimental and Therapeutic Medicine, 15, 2374-2380. https://doi.org/10.3892/etm.2018.5692
MLA
Zhu, Z., Huang, Z., Li, Z., Li, X., Du, C., Tian, Y."Multiple brain abscesses caused by infection with Candida glabrata: A case report". Experimental and Therapeutic Medicine 15.3 (2018): 2374-2380.
Chicago
Zhu, Z., Huang, Z., Li, Z., Li, X., Du, C., Tian, Y."Multiple brain abscesses caused by infection with Candida glabrata: A case report". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2374-2380. https://doi.org/10.3892/etm.2018.5692
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team