Effect of activated charcoal hemoperfusion on renal function in patients with paraquat poisoning

Sun,Liang; Yan,Peng‑Bo; Zhang,Yin; Wei,Lu‑Qing; Li,Guo‑Qiang

doi:10.3892/etm.2018.5712

March-2018 Volume 15 Issue 3

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March-2018 Volume 15 Issue 3

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Article

Effect of activated charcoal hemoperfusion on renal function in patients with paraquat poisoning

Authors:
- Liang Sun
- Peng‑Bo Yan
- Yin Zhang
- Lu‑Qing Wei
- Guo‑Qiang Li
View Affiliations / Copyright

Affiliations: Department of Respiratory and Critical Care Medicine of Pingjing Hospital, Affiliated Hospital of Logistics University of Chinese People's Armed Police Force, Tianjin 300162, P.R. China
Pages: 2688-2692
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Published online on: January 5, 2018

https://doi.org/10.3892/etm.2018.5712
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Abstract

The present study retrospectively analyzed 19 patients diagnosed with paraquat (PQ) poisoning with the aim to investigate the effect of activated charcoal hemoperfusion on renal function and PQ elimination. The results indicated that 7 patients died and 12 survived. Non‑oliguric renal failure occurred in all of the 7 patients who died. Among the 12 surviving patients, 10 had normal renal function and 2 developed non‑oliguric renal failure. There was a linear correlation between plasma and urine paraquat concentration prior to and during activated charcoal hemoperfusion. The equation parameters together with the correlation coefficient on admission were as follows: Y=0.5820+1.7348X (R2=0.678; F=35.768; P<0.0001). The equation parameters together with the correlation coefficient were as follows during activated charcoal hemoperfusion: Y=0.6827+1.2649X (R2=0.626; F=50.308; P<0.0001). Therefore, it was concluded that in patients with normal renal function, the elimination kinetics of PQ by the kidneys were only associated with the plasma PQ concentration. Activated charcoal hemoperfusion had little effect on avoiding acute kidney injury in patients with severe PQ poisoning.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of activated charcoal hemoperfusion on renal function in patients with paraquat poisoning

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