Effect of activated charcoal hemoperfusion on renal function in patients with paraquat poisoning
- Authors:
- Liang Sun
- Peng‑Bo Yan
- Yin Zhang
- Lu‑Qing Wei
- Guo‑Qiang Li
View Affiliations
Affiliations: Department of Respiratory and Critical Care Medicine of Pingjing Hospital, Affiliated Hospital of Logistics University of Chinese People's Armed Police Force, Tianjin 300162, P.R. China
- Published online on: January 5, 2018 https://doi.org/10.3892/etm.2018.5712
-
Pages:
2688-2692
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
The present study retrospectively analyzed 19 patients diagnosed with paraquat (PQ) poisoning with the aim to investigate the effect of activated charcoal hemoperfusion on renal function and PQ elimination. The results indicated that 7 patients died and 12 survived. Non‑oliguric renal failure occurred in all of the 7 patients who died. Among the 12 surviving patients, 10 had normal renal function and 2 developed non‑oliguric renal failure. There was a linear correlation between plasma and urine paraquat concentration prior to and during activated charcoal hemoperfusion. The equation parameters together with the correlation coefficient on admission were as follows: Y=0.5820+1.7348X (R2=0.678; F=35.768; P<0.0001). The equation parameters together with the correlation coefficient were as follows during activated charcoal hemoperfusion: Y=0.6827+1.2649X (R2=0.626; F=50.308; P<0.0001). Therefore, it was concluded that in patients with normal renal function, the elimination kinetics of PQ by the kidneys were only associated with the plasma PQ concentration. Activated charcoal hemoperfusion had little effect on avoiding acute kidney injury in patients with severe PQ poisoning.
View References
1
|
Jones GM and Vale JA: Mechanisms of
toxicity, clinical features, and management of diquat poisoning: A
review. J Toxicol Clin Toxicol. 38:123–128. 2000. View Article : Google Scholar : PubMed/NCBI
|
2
|
Hsu CW, Lin JL, Lin-Tan DT, Chen KH, Yen
TH, Wu MS and Lin SC: Early hemoperfusion may improve survival of
severely paraquat-poisoned patients. PLoS One. 7:e483972012.
View Article : Google Scholar : PubMed/NCBI
|
3
|
Kang MS, Gil HW, Yang JO, Lee EY and Hong
SY: Comparison between kidney and hemoperfusion for paraquat
elimination. J Korean Med Sci. 24 Suppl:S156–S160. 2009. View Article : Google Scholar : PubMed/NCBI
|
4
|
Pavan M: Acute kidney injury following
paraquat poisoning in india. Iran J Kidney Dis. 7:64–66.
2013.PubMed/NCBI
|
5
|
Hawksworth GM, Bennett PN and Davies DS:
Kinetics of paraquat elimination in the dog. Toxicol Appl
Pharmacol. 57:139–145. 1981. View Article : Google Scholar : PubMed/NCBI
|
6
|
Hu L, Hong G, Ma J, Wang X, Lin G, Zhang X
and Lu Z: Clearance rate and BP-ANN model in paraquat poisoned
patients treated with hemoperfusion. Biomed Res Int.
2015:2982532015. View Article : Google Scholar : PubMed/NCBI
|
7
|
Pond SM, Rivory LP, Hampson EC and Roberts
MS: Kinetics of toxic doses of paraquat and the effects of
hemoperfusion in the dog. J Toxicol Clin Toxicol. 31:229–246. 1993.
View Article : Google Scholar : PubMed/NCBI
|
8
|
Hong SY, Yang JO, Lee EY and Kim SH:
Effect of haemoperfusion on plasma paraquat concentration in vitro
and in vivo. Toxicol Ind Health. 19:17–23. 2003. View Article : Google Scholar : PubMed/NCBI
|
9
|
Posecion NC, Ostrea EM and Bielawski DM:
Quantitative determination of paraquat in meconium by sodium
borohydride-nickel chloride chemical reduction and gas
chromatography/mass spectrometry (GC/MS). J Chromatogr B Analyt
Technol Biomed Life Sci. 862:93–99. 2008. View Article : Google Scholar : PubMed/NCBI
|
10
|
Ikebuchi J: Evaluation of paraquat
concentrations in paraquat poisoning. Arch Toxicol. 60:304–310.
1987. View Article : Google Scholar : PubMed/NCBI
|