Discrimination of malignant transformation from benign endometriosis using a near‑infrared approach

Kawahara,Naoki; Yamada,Yuki; Ito,Fuminori; Hojo,Wataru; Iwabuchi,Takuya; Kobayashi,Hiroshi

doi:10.3892/etm.2018.5779

March-2018 Volume 15 Issue 3

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March-2018 Volume 15 Issue 3

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Article

Discrimination of malignant transformation from benign endometriosis using a near‑infrared approach

Authors:
- Naoki Kawahara
- Yuki Yamada
- Fuminori Ito
- Wataru Hojo
- Takuya Iwabuchi
- Hiroshi Kobayashi
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara 634‑8522, Japan, Department of Research and Development, Cellspect Co., Ltd., Morioka, Iwate 020‑0857, Japan
Pages: 3000-3005
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Published online on: January 19, 2018

https://doi.org/10.3892/etm.2018.5779
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Abstract

The aim of the present single-center retrospective study was to investigate the discrimination of malignant transformation from ovarian endometrioma (OE) using a near‑infrared approach ex vivo. Cystic fluid samples were collected from patients with OE (n=34) and endometriosis‑associated ovarian cancer (EAOC) (n=12). The light reflected from each sample of cystic fluid [change in luminance, Δl (cd/m2) = background luminance‑cystic fluid luminance at 800 nm] was spectrally measured by a near‑infrared CCD camera with band‑path filter (800 nm). The Δl in EAOC was significantly lower compared with that in OE. On regression analysis, a positive correlation was observed between the Δl and Hb level in the cystic fluid, and this association was exponential. The diagnostic sensitivity and specificity of Δl was 83.3 and 94.1% at the cutoff value of 21.5 cd/m2, with an area under the ROC curve of 0.897. The present ex vivo study potentially provides a powerful near‑infrared approach for quantitative discrimination between EAOC and benign OE, with high sensitivity and specificity, which may have clinical applications.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Discrimination of malignant transformation from benign endometriosis using a near‑infrared approach

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