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Article

Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection

  • Authors:
    • Bin Zhou
    • Defeng Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Affiliated Yangming Hospital of Ningbo University, Yuyao People's Hospital, Yuyao, Zhejiang 315400, P.R. China
  • Pages: 2985-2989
    |
    Published online on: January 24, 2018
       https://doi.org/10.3892/etm.2018.5790
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Abstract

Infection following orthopedic surgery is a major complication that can have serious implications on patient health. The present study aimed to investigate the antibacterial effects of bacteriocins obtained from Lactobacillus rhamnosus on a rabbit model of Staphylococcus aureus infection following knee replacement surgery. Blood samples were collected 1, 2, 3, 4 and 5 days after bacteriocin injection, and C‑reactive protein (CRP) and interleukin (IL)‑6 levels were measured using commercial ELISA kits. In addition, biofilm formation was evaluated by fluorescence microscopy. Bacteriocins were identified to exhibit significant inhibitory effects on Staphylococcus aureus biofilm formation, and on CRP and IL‑6 levels in the serum, following surgery and infection (all P<0.05 vs. the control group). The results of the present study indicate that bacteriocins are a potential agent for the prevention of orthopedic postoperative infections.
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1 

Berthelot P, Grattard F, Cazorla C, Passot JP, Fayard JP, Meley R, Bejuy J, Farizon F, Pozzetto B and Lucht F: Is nasal carriage of Staphylococcus aureus the main acquisition pathway for surgical-site infection in orthopaedic surgery? Europ J Clin Microbiol. 4:373–382. 2001.

2 

Malawski SK and Lukawski S: Pyogenic infection of the spine. Clin Orthop Relat Res. 1–66. 1991.

3 

Hennekinne JA, De Buyser ML and Dragacci S: Staphylococcus aureus and its food poisoning toxins: Characterization and outbreak investigation. FEMS Microbiol Rev. 36:815–36. 2012. View Article : Google Scholar

4 

Kusunoki T, Hailman E, Juan TS, Lichenstein HS and Wright SD: Molecules from Staphylococcus aureus that bind CD14 and stimulate innate immune responses. J Exp Med. 182:1673–1682. 1995. View Article : Google Scholar

5 

Tennant A, Fear J, Pickering A, Hillman M, Cutts A and Chamberlain MA: Prevalence of knee problems in the population aged 55 years and over: Identifying the need for knee arthroplasty. BMJ Clin Res. 310:1291–1293. 1995. View Article : Google Scholar

6 

Zimmerli W and Ochsner PE: Management of infection associated with prosthetic joints. Infection. 31:99–108. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Nes IF, Diep DB, Håvarstein LS, Brurberg MB, Eijsink V and Holo H: Biosynthesis of bacteriocins in lactic acid bacteria. Antonie Van Leeuwenhoek. 70:113–128. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Janes ME, Nannapaneni R and Johnson MG: Identification and characterization of two bacteriocin-producing bacteria isolated from garlic and ginger root. J Food Prot. 62:899–904. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Li W, Ji J, Chen X, Jiang M, Rui X and Dong M: Structural elucidation and antioxidant activities of exopolysaccharides from Lactobacillus helveticus MB2-1. Carbohyd Polym. 102:351–359. 2014. View Article : Google Scholar

10 

Biosa G, Addis MF, Tanca A, Pisanu S, Roggio T, Uzzau S and Pagnozzi D: Comparison of blood serum peptide enrichment methods by Tricine SDS-PAGE and mass spectrometry. J Proteom. 75:93–99. 2011. View Article : Google Scholar

11 

Ortiz-Butron R, Pacheco-Rosado J, Hernández-Garcia A, Briones-Velasco M and Rocha L: Mild thyroid hormones deficiency modifies benzodiazepine and mu-opioid receptor binding in rats. Neuropharmacology. 44:111–116. 2003. View Article : Google Scholar : PubMed/NCBI

12 

National Research C, . Guide for the care and use of laboratory animals. National Academies Press; 2010, PubMed/NCBI

13 

Slauterbeck J, Clevenger C, Lundberg W and Burchfield DM: Estrogen level alters the failure load of the rabbit anterior cruciate ligament. J Ortho Res. 17:405–408. 1999. View Article : Google Scholar

14 

Jackson S, Coulthwaite L, Loewy Z, Scallan A and Verran J: Biofilm development by blastospores and hyphae of Candida albicans on abraded denture acrylic resin surfaces. J Prosth Dent. 112:988–993. 2014. View Article : Google Scholar

15 

Wang YC, Yo YT, Lee HY, Liao YP, Chao TK, Su PH and Lai HC: ALDH1-bright epithelial ovarian cancer cells are associated with CD44 expression, drug resistance, and poor clinical outcome. Am J Patho. 180:1159–1169. 2012. View Article : Google Scholar

16 

Costerton JW, Cheng KJ, Geesey GG, Ladd TI, Nickel JC, Dasgupta M and Marrie TJ: Bacterial biofilms in nature and disease. Ann Rev Microbiol. 41:435–464. 1987. View Article : Google Scholar

17 

Uçkay I, Hoffmeyer P, Lew D and Pittet D: Prevention of surgical site infections in orthopaedic surgery and bone trauma: State-of-the-art update. J Hosp Infect. 84:5–12. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Davies D: Understanding biofilm resistance to antibacterial agents. Nat Rev Drug Discov. 2:114–123. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Gong K, Wang BJ, Liu M, Jiang KY, Qiu CW, Luo ZY, Fan RY and Wang L: The influence of lactic acid bacteria and metabolites on intestinal microflora and nonspecific immunity of juvenile sea cucumber (Apostichopus japonicus). Mar Sci. 37:7–12. 2013.

20 

Klaenhammer TR: Genetics of bacteriocins produced by lactic acid bacteria. FEMS Microbiol Rev. 12:39–85. 1993. View Article : Google Scholar : PubMed/NCBI

21 

Reid G, Jass J, Sebulsky MT and Mccormick JK: Potential uses of probiotics in clinical practice. Clin Microbiol Rev. 16:658–672. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Zaghian S, Emtiazi G and Shokri D: A bacteriocin with broad antimicrobial activity produced by newly isolated nitrogen-fixing bacillus strains. J Isfahan Med Sch. 30:2260–2269. 2013.

23 

Macintyre SS, Schultz D and Kushner I: Biosynthesis of C-reactive protein. Ann NY Acad Sci. 389:76–87. 1982. View Article : Google Scholar : PubMed/NCBI

24 

Wilson AM, Ryan MC and Boyle AJ: The novel role of C-reactive protein in cardiovascular disease: Risk marker or pathogen. Int J Cardiol. 106:291–297. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Li YP and Stashenko P: Proinflammatory cytokines tumor necrosis factor-alpha and IL-6, but not IL-1, down-regulate the osteocalcin gene promoter. J Immun. 148:788–794. 1992.PubMed/NCBI

26 

Moore TC, Cody L, Kumm PM, Brown DM and Petro TM: IRF3 helps control acute TMEV infection through IL-6 expression but contributes to acute hippocampus damage following TMEV infection. Virus Res. 178:226–233. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Saiki R, Hayashi D, Ikuo Y, Nishimura K, Ishii I, Kobayashi K, Kan C, Toida T, Kashiwagi K and Igarashi K: Acrolein stimulates the synthesis of IL-6 and C-reactive protein (CRP) in thrombosis model mice and cultured cells. J Neurochem. 127:652–659. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Campoccia D, Montanaro L and Arciola CR: The significance of infection related to orthopedic devices and issues of antibiotic resistance. Biomater. 27:2331–2339. 2006. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhou B and Zhang D: Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection. Exp Ther Med 15: 2985-2989, 2018.
APA
Zhou, B., & Zhang, D. (2018). Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection. Experimental and Therapeutic Medicine, 15, 2985-2989. https://doi.org/10.3892/etm.2018.5790
MLA
Zhou, B., Zhang, D."Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection". Experimental and Therapeutic Medicine 15.3 (2018): 2985-2989.
Chicago
Zhou, B., Zhang, D."Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2985-2989. https://doi.org/10.3892/etm.2018.5790
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou B and Zhang D: Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection. Exp Ther Med 15: 2985-2989, 2018.
APA
Zhou, B., & Zhang, D. (2018). Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection. Experimental and Therapeutic Medicine, 15, 2985-2989. https://doi.org/10.3892/etm.2018.5790
MLA
Zhou, B., Zhang, D."Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection". Experimental and Therapeutic Medicine 15.3 (2018): 2985-2989.
Chicago
Zhou, B., Zhang, D."Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2985-2989. https://doi.org/10.3892/etm.2018.5790
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