Open Access

Assessment of telomerase activity in leukocytes of type 2 diabetes mellitus patients having or not foot ulcer: Possible correlation with other clinical parameters

  • Authors:
    • Dimitrios Baltzis
    • Evangelia Meimeti
    • Maria G. Grammatikopoulou
    • Matthieu Roustit
    • Eleni Mavrogonatou
    • Dimitris Kletsas
    • Smaragda Efraimidou
    • Christos Manes
    • Taxiarchis K. Nikolouzakis
    • John Tsiaoussis
    • Aristides M. Tsatsakis
    • Demetrios A. Spandidos
    • Christina-Maria Trakatelli
    • Nikolaos Drakoulis
  • View Affiliations

  • Published online on: January 25, 2018     https://doi.org/10.3892/etm.2018.5798
  • Pages: 3420-3424
  • Copyright: © Baltzis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Telomerase is the enzyme that maintains telomere length by adding telomeric repeats after each cell division. Numerous metabolic factors such as obesity, insulin resistance or physical inactivity have been associated with shortened telomeres. In the present study, we assessed telomerase activity in diabetic patients having or not foot ulcer. A total of 90 adult patients with type 2 diabetes mellitus (T2DM) were studied. Patients were allocated into two groups according to the absence or presence of active foot ulcers as follows: Νon-ulcer group (N=58) and ulcer group (N=32). Our data revealed that the patients with diabetic ulcers had significantly greater waist circumference and neuropathy disability score, while exhibiting lower telomerase activity, indicating the possible existence of a common clinical profile among ulcer-bearing diabetic patients. Validation of our findings by extending the study in larger patient groups may contribute to the understanding of T2DM pathophysiology and its main clinical implications.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Baltzis D, Meimeti E, Grammatikopoulou MG, Roustit M, Mavrogonatou E, Kletsas D, Efraimidou S, Manes C, Nikolouzakis TK, Tsiaoussis J, Tsiaoussis J, et al: Assessment of telomerase activity in leukocytes of type 2 diabetes mellitus patients having or not foot ulcer: Possible correlation with other clinical parameters. Exp Ther Med 15: 3420-3424, 2018
APA
Baltzis, D., Meimeti, E., Grammatikopoulou, M.G., Roustit, M., Mavrogonatou, E., Kletsas, D. ... Drakoulis, N. (2018). Assessment of telomerase activity in leukocytes of type 2 diabetes mellitus patients having or not foot ulcer: Possible correlation with other clinical parameters. Experimental and Therapeutic Medicine, 15, 3420-3424. https://doi.org/10.3892/etm.2018.5798
MLA
Baltzis, D., Meimeti, E., Grammatikopoulou, M. G., Roustit, M., Mavrogonatou, E., Kletsas, D., Efraimidou, S., Manes, C., Nikolouzakis, T. K., Tsiaoussis, J., Tsatsakis, A. M., Spandidos, D. A., Trakatelli, C., Drakoulis, N."Assessment of telomerase activity in leukocytes of type 2 diabetes mellitus patients having or not foot ulcer: Possible correlation with other clinical parameters". Experimental and Therapeutic Medicine 15.4 (2018): 3420-3424.
Chicago
Baltzis, D., Meimeti, E., Grammatikopoulou, M. G., Roustit, M., Mavrogonatou, E., Kletsas, D., Efraimidou, S., Manes, C., Nikolouzakis, T. K., Tsiaoussis, J., Tsatsakis, A. M., Spandidos, D. A., Trakatelli, C., Drakoulis, N."Assessment of telomerase activity in leukocytes of type 2 diabetes mellitus patients having or not foot ulcer: Possible correlation with other clinical parameters". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3420-3424. https://doi.org/10.3892/etm.2018.5798