Open Access

Association between HLA gene polymorphism and cutaneous adverse reactions caused by antiepileptic drugs

  • Authors:
    • Jingang Zhang
    • Xinrui Li
    • Yuanyuan Su
    • Min Sun
    • Junbang Wang
    • Yunhua Hao
  • View Affiliations

  • Published online on: January 25, 2018     https://doi.org/10.3892/etm.2018.5801
  • Pages: 3399-3403
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The association between cutaneous adverse drug reactions (cADRs) caused by antiepileptic drugs (AEDs) and human leukocyte antigen‑A (HLA-A) and HLA-B genes in Chinese Han population in Shanghai was investigated. Through the case-control study, 30 child patients with AED-induced cADRs (cADRs group), 60 AED-tolerant child patients (AED-tolerant group) and 60 normal children not taking AEDs (normal group) were collected. The HLA-B*15:02 and HLA-A*31:01 genotypes were detected using the polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) probe method, and the correlation of HLA-B*15:02 and HLA-A*31:01 genes with the incidence of cADRs was analyzed. The positive rate of HLA-B*15:02 gene was 83.33% in the cADRs group, which was significantly increased compared with that in the AED-tolerant and normal groups (P<0.01). The positive rate of HLA-A*31:01 gene was 63.33% in the cADRs group, which was obviously increased compared with that in the AED-tolerant and normal groups (P<0.01). There were no significant differences in HLA-B*15:02 and HLA-A*31:01 genotypes between the AED-tolerant and normal groups (P>0.05). The results showed that HLA-B*15:02 and HLA-A*31:01 are significantly associated with cADRs in a Chinese Han population in Shanghai, suggesting that HLA-B*15:02 and HLA-A*31:01 genotypes should be detected in the application of AEDs.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang J, Li X, Su Y, Sun M, Wang J and Hao Y: Association between HLA gene polymorphism and cutaneous adverse reactions caused by antiepileptic drugs. Exp Ther Med 15: 3399-3403, 2018
APA
Zhang, J., Li, X., Su, Y., Sun, M., Wang, J., & Hao, Y. (2018). Association between HLA gene polymorphism and cutaneous adverse reactions caused by antiepileptic drugs. Experimental and Therapeutic Medicine, 15, 3399-3403. https://doi.org/10.3892/etm.2018.5801
MLA
Zhang, J., Li, X., Su, Y., Sun, M., Wang, J., Hao, Y."Association between HLA gene polymorphism and cutaneous adverse reactions caused by antiepileptic drugs". Experimental and Therapeutic Medicine 15.4 (2018): 3399-3403.
Chicago
Zhang, J., Li, X., Su, Y., Sun, M., Wang, J., Hao, Y."Association between HLA gene polymorphism and cutaneous adverse reactions caused by antiepileptic drugs". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3399-3403. https://doi.org/10.3892/etm.2018.5801