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Article

Pterostilbene attenuates acute kidney injury in septic mice

  • Authors:
    • Yizi Xia
    • Ying Chen
    • Luming Tang
    • Zheng Wang
    • Yu Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China, Department of Nephrology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China
  • Pages: 3551-3555
    |
    Published online on: January 30, 2018
       https://doi.org/10.3892/etm.2018.5808
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Abstract

Acute kidney injury (AKI) is a severe complication of sepsis with a high mortality and morbidity. Pterostilbene (Pte) has been suggested to confer anti‑apoptotic and anti‑inflammatory effects. In the current study, the effects of Pte on AKI were evaluated in septic mice. Cecal ligation and puncture surgery was performed to induce sepsis. The results suggested that Pte administration significantly decreased the levels of serum urea nitrogen and creatinine, and improved the survival rate of septic mice. Additionally, the renal injury induced by sepsis was attenuated by pterostilbene treatment. Notably, pterostilbene reduced Bcl‑2‑associated X protein expression, and levels of interleukin‑1β and tumor necrosis factor‑α, and upregulated B‑cell lymphoma 2 expression. The results indicate that pterostilbene may serve as a potential therapeutic candidate for the treatment of AKI induced by sepsis.
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Copy and paste a formatted citation
Spandidos Publications style
Xia Y, Chen Y, Tang L, Wang Z and Zheng Y: Pterostilbene attenuates acute kidney injury in septic mice. Exp Ther Med 15: 3551-3555, 2018.
APA
Xia, Y., Chen, Y., Tang, L., Wang, Z., & Zheng, Y. (2018). Pterostilbene attenuates acute kidney injury in septic mice. Experimental and Therapeutic Medicine, 15, 3551-3555. https://doi.org/10.3892/etm.2018.5808
MLA
Xia, Y., Chen, Y., Tang, L., Wang, Z., Zheng, Y."Pterostilbene attenuates acute kidney injury in septic mice". Experimental and Therapeutic Medicine 15.4 (2018): 3551-3555.
Chicago
Xia, Y., Chen, Y., Tang, L., Wang, Z., Zheng, Y."Pterostilbene attenuates acute kidney injury in septic mice". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3551-3555. https://doi.org/10.3892/etm.2018.5808
Copy and paste a formatted citation
x
Spandidos Publications style
Xia Y, Chen Y, Tang L, Wang Z and Zheng Y: Pterostilbene attenuates acute kidney injury in septic mice. Exp Ther Med 15: 3551-3555, 2018.
APA
Xia, Y., Chen, Y., Tang, L., Wang, Z., & Zheng, Y. (2018). Pterostilbene attenuates acute kidney injury in septic mice. Experimental and Therapeutic Medicine, 15, 3551-3555. https://doi.org/10.3892/etm.2018.5808
MLA
Xia, Y., Chen, Y., Tang, L., Wang, Z., Zheng, Y."Pterostilbene attenuates acute kidney injury in septic mice". Experimental and Therapeutic Medicine 15.4 (2018): 3551-3555.
Chicago
Xia, Y., Chen, Y., Tang, L., Wang, Z., Zheng, Y."Pterostilbene attenuates acute kidney injury in septic mice". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3551-3555. https://doi.org/10.3892/etm.2018.5808
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