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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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April-2018 Volume 15 Issue 4

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Article

Risk factors for new-onset chronic kidney disease in patients who have received a liver transplant

  • Authors:
    • Yuehong Li
    • Binbin Li
    • Wei Wang
    • Jiaxuan Lv
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, P.R. China
  • Pages: 3589-3595
    |
    Published online on: January 31, 2018
       https://doi.org/10.3892/etm.2018.5823
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Abstract

The aim of the present study was to analyze the risk factors for new‑onset chronic kidney disease (CKD) in patients who have received a liver transplant. A total of 190 patients who underwent liver transplantation between March 2001 and January 2015 were followed up, and analyzed retrospectively. Sex, age, primary disease, preoperative laboratory findings (hemoglobin, albumin, creatinine and glomerular filtration rate), surgical approach, blood loss during the surgery and transfusion volume, postoperative complications, and the average levels of calcineurin inhibitors (CNIs) (from liver transplantation to the onset of CKD) were analyzed. In total, 40 patients developed new‑onset CKD after transplantation. Clinical data in the new‑onset CKD group were compared with the non‑CKD group. A χ2 test, t‑test and logistic regression analysis were performed using SPSS 17.0 software. The incidence of new‑onset CKD after liver transplantation was 21.1%. Renal pathology included IgA nephropathy, hepatitis B virus‑associated nephropathy, membranous proliferative glomerulonephritis, focal segmental glomerular sclerosis and cryoglobulinemia-associated renal injury. Among the CKD patients, 85.7% had tubulointerstitial damage. Univariate analysis showed that preoperative renal function, hemoglobin, intraoperative blood loss and transfusion volume, postoperative acute kidney injury, average levels of CNIs, and hypertension were risk factors for new‑onset CKD after liver transplantation. Logistic regression analysis showed that preoperative glomerular filtration rate [odds ratio (OR)=0.980, P=0.041], hemoglobin (OR=0.972, P=0.034), average levels of CNIs (OR=1.364, P=0.015) and hypertension (OR=4.833, P=0.048)] were independent risk factors for new‑onset CKD. The incidence of new‑onset CKD in patients who received liver transplantation was high. The main risk factors were identified to be preoperative glomerular filtration rate, hemoglobin, postoperative average levels of CNIs and hypertension.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Li B, Wang W and Lv J: Risk factors for new-onset chronic kidney disease in patients who have received a liver transplant. Exp Ther Med 15: 3589-3595, 2018.
APA
Li, Y., Li, B., Wang, W., & Lv, J. (2018). Risk factors for new-onset chronic kidney disease in patients who have received a liver transplant. Experimental and Therapeutic Medicine, 15, 3589-3595. https://doi.org/10.3892/etm.2018.5823
MLA
Li, Y., Li, B., Wang, W., Lv, J."Risk factors for new-onset chronic kidney disease in patients who have received a liver transplant". Experimental and Therapeutic Medicine 15.4 (2018): 3589-3595.
Chicago
Li, Y., Li, B., Wang, W., Lv, J."Risk factors for new-onset chronic kidney disease in patients who have received a liver transplant". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3589-3595. https://doi.org/10.3892/etm.2018.5823
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Li B, Wang W and Lv J: Risk factors for new-onset chronic kidney disease in patients who have received a liver transplant. Exp Ther Med 15: 3589-3595, 2018.
APA
Li, Y., Li, B., Wang, W., & Lv, J. (2018). Risk factors for new-onset chronic kidney disease in patients who have received a liver transplant. Experimental and Therapeutic Medicine, 15, 3589-3595. https://doi.org/10.3892/etm.2018.5823
MLA
Li, Y., Li, B., Wang, W., Lv, J."Risk factors for new-onset chronic kidney disease in patients who have received a liver transplant". Experimental and Therapeutic Medicine 15.4 (2018): 3589-3595.
Chicago
Li, Y., Li, B., Wang, W., Lv, J."Risk factors for new-onset chronic kidney disease in patients who have received a liver transplant". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3589-3595. https://doi.org/10.3892/etm.2018.5823
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