Therapeutic effects of Hedyotis diffusa Willd in a COPD mouse model challenged with LPS and smoke

Liu,Renping; Wang,Peihong; Wu,Caiqing; Chen,Juan; Li,Chengxin; Xie,Yongtao; Wang,Qi; Liu,Jianming; He,Huan; Zhu,Jing

doi:10.3892/etm.2018.5851

April-2018 Volume 15 Issue 4

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April-2018 Volume 15 Issue 4

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Article Open Access

Therapeutic effects of Hedyotis diffusa Willd in a COPD mouse model challenged with LPS and smoke

Authors:
- Renping Liu
- Peihong Wang
- Caiqing Wu
- Juan Chen
- Chengxin Li
- Yongtao Xie
- Qi Wang
- Jianming Liu
- Huan He
- Jing Zhu
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Affiliations: Medical Experiment Education Department, Medical College of Nanchang University, Nanchang, Jiangxi 330031, P.R. China, Department of Pharmacology, Jiangxi Medical College, Shangrao, Jiangxi 334000, P.R. China, Department of Pharmacology, Fuzhou Medical College of Nanchang University, Fuzhou, Fujian 344000, P.R. China

Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 3385-3391
|
Published online on: February 8, 2018

https://doi.org/10.3892/etm.2018.5851
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Abstract

Hedyotis diffusa Willd (HDW) is a constituent of several Chinese medicines used clinically to treat inflammatory diseases, including airway inflammation. The aim of the present study was to investigate whether HDW serves a protective role in suppressing chronic airway inflammation and its underlying mechanisms. A mouse model of chronic smoking was induced via exposure to cigarette smoke (CS) for 30 days, increasing the exposure time for up to 5 min per day and the administration of lipopolysaccharide (LPS). Mice were gavaged with HDW (50 or 100 mg/kg body weight), dexamethasone (1 mg/kg body weight) or normal saline (NS, 0.9%) 1 h prior to CS challenge. Compared with CS and LPS (SL)‑induced mice, the levels of interleukin (IL)‑1β, tumor necrosis factor‑α and transforming growth factor‑β in bronchoalveolar lavage fluid from HDW+SL mice were significantly decreased and IL‑10 was markedly reduced. Histological examination of the lung tissues revealed that HDW treatment alleviates airway inflammation. In addition, the administration of HDW to human bronchial epithelial BEAS‑2B cells suppressed the activity of the nuclear factor (NF)‑κB signaling pathway. The results of the present study demonstrate that HDW has a therapeutic effect in COPD and the underlying mechanism may be attributed to inhibition of the NF‑κB pathway.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Therapeutic effects of Hedyotis diffusa Willd in a COPD mouse model challenged with LPS and smoke

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