Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Relationship of melatonin level, oxidative stress and inflammatory status with osteoporosis in maintenance hemodialysis of chronic renal failure

  • Authors:
    • Haiwei Ren
    • Renlian Sun
    • Jian Wang
  • View Affiliations / Copyright

    Affiliations: Department of Dialysis, Dezhou People's Hospital, Dezhou, Shandong 253014, P.R. China, Department of Nephrology, Dezhou People's Hospital, Dezhou, Shandong 253014, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5183-5188
    |
    Published online on: February 12, 2018
       https://doi.org/10.3892/etm.2018.5857
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The relationship of melatonin (MT) level, oxidative stress and inflammatory status with osteoporosis in the maintenance hemodialysis (MHD) of chronic renal failure was investigated. Ninety-four patients with chronic renal failure treated in Dezhou People's Hospital (Shandong, China) and receiving MHD for more than 3 months from May to April 2017 were selected and divided into the osteoporosis group (observation group, n=49) and the non-osteoporosis group (control group, n=45) based on whether osteoporosis was involved. The serum advanced oxidation protein products (AOPP), MT level and inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-1] in patients were detected via enzyme-linked immunosorbent assay (ELISA). Moreover, the malondialdehyde (MDA) level in serum was detected via thibabituric acid (TBA) assay and the spinal bone mineral density (BMD) was detected using the total BMD testing instrument, followed by correlation analysis. The MT level in observation group was significantly lower than that in control group, but the levels of AOPP and MDA were significantly higher than those in control group (P<0.05). The levels of inflammatory factors (TNF-α, IL-6 and IL-1) in observation group were obviously higher than those in the control group (P<0.05). Besides, the spinal BMD and T-value in observation group were significantly lower than those in the control group (P<0.05). Pearson's correlation analysis showed that AOPP, MDA, TNF-α, IL-6 and IL-1 levels were negatively correlated with BMD, but MT was positively correlated with BMD (P<0.05). Osteoporosis occurs easily in MHD patients; oxidative stress and inflammatory degree are negatively correlated with osteoporosis, but MT is positively correlated with osteoporosis.
View Figures

Figure 1

Figure 2

View References

1 

Jeremiah MP, Unwin BK, Greenawald MH and Casiano VE: Diagnosis and management of osteoporosis. Am Fam Physician. 92:261–268. 2015.PubMed/NCBI

2 

Shigematsu T, Muraoka R, Sugimoto T and Nishizawa Y: Risedronate therapy in patients with mild-to-moderate chronic kidney disease with osteoporosis: Post-hoc analysis of data from the risedronate phase III clinical trials. BMC Nephrol. 18:662017. View Article : Google Scholar : PubMed/NCBI

3 

Del Vecchio L, Locatelli F and Carini M: What we know about oxidative stress in patients with chronic kidney disease on dialysis - clinical effects, potential treatment, and prevention. Semin Dial. 24:56–64. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Oh DJ, Kim HR, Lee MK and Woo YS: Profile of human β-defensins 1,2 and proinflammatory cytokines (TNF-α, IL-6) in patients with chronic kidney disease. Kidney Blood Press Res. 37:602–610. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Zhang WL, Meng HZ, Yang RF, Yang MW, Sun GH, Liu JH, Shi PX, Liu F and Yang B: Melatonin suppresses autophagy in type 2 diabetic osteoporosis. Oncotarget. 7:52179–52194. 2016.PubMed/NCBI

6 

Tanaka T, Latorre MRDO, Jaime PC, Florindo AA, Pippa MG and Zerbini CA: Risk factors for proximal femur osteoporosis in men aged 50 years or older. Osteoporos Int. 12:942–949. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S and Lindsay R: National Osteoporosis Foundation: Clinician's guide to prevention and treatment of osteoporosis. Osteoporos Int. 25:2359–2381. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Arnao MB and Hernández-Ruiz J: Functions of melatonin in plants: A review. J Pineal Res. 59:133–150. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Pinto AR, da Silva NC and Pinato L: Analyses of melatonin, cytokines, and sleep in chronic renal failure. Sleep Breath. 20:339–344. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Tocher DR, Mourente G, Van Der Eecken A, Evjemo JO, Diaz E, Bell JG, Geurden I, Lavens P and Olsen Y: Effects of dietary vitamin E on antioxidant defence mechanisms of juvenile turbot (Scophthalmusmaximus L.), halibut (Hippoglossushippoglossus L.) and sea bream (Sparusaurata L.). Aquacult Nutr. 8:195–207. 2002. View Article : Google Scholar

11 

Maes M, Ruckoanich P, Chang YS, Mahanonda N and Berk M: Multiple aberrations in shared inflammatory and oxidative & nitrosative stress (IO&NS) pathways explain the co-association of depression and cardiovascular disorder (CVD), and the increased risk for CVD and due mortality in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry. 35:769–783. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Tang X, Rong G, Bu Y, Zhang S, Zhang M, Zhang J and Liang X: Advanced oxidation protein products induce hypertrophy and epithelial-to-mesenchymal transition in human proximal tubular cells through induction of endoplasmic reticulum stress. Cell Physiol Biochem. 35:816–828. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Zhao XQ, Liang B, Liu Y and Huang XQ: Agaricoglycerides protect against hepatic ischemia/reperfusion injury by attenuating inflammatory response, oxidative stress, and expression of NF-κB. Evid Based Complement Alternat Med. 2015:1427362015. View Article : Google Scholar : PubMed/NCBI

14 

Izadyar S, Golbarg S, Takavar A and Zakariaee SS: The effect of the lumbar vertebral malpositioning on bone mineral density measurements of the lumbar spine by dual-energy X-ray absorptiometry. J Clin Densitom. 19:277–281. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Norouzi J, Yadollahpour A, Mirbagheri SA, Mazdeh MM and Hosseini SA: Predicting renal failure progression in chronic kidney disease using integrated intelligent fuzzy expert system. Comput Math Methods Med. 2016:60808142016. View Article : Google Scholar : PubMed/NCBI

16 

Pedersen BK and Febbraio M: Exercise and interleukin-6 action. Expert Rev Endocrinol Metab. 1:319–321. 2014. View Article : Google Scholar

17 

Yang L, Zhang J and Wang G: The effect of sodium hyaluronate treating knee osteoarthritis on synovial fluid interleukin-1β and clinical treatment mechanism. Pak J Pharm Sci. 28 Suppl 1:407–410. 2015.PubMed/NCBI

18 

Yoo YM, Han TY and Kim HS: Melatonin suppresses autophagy induced by clinostat in preosteoblast MC3T3-E1 cells. Int J Mol Sci. 17:5262016. View Article : Google Scholar : PubMed/NCBI

19 

Zong Y, Chen J, Guo J-Z, Zhang X-J, Zhang T-J and Sun L: Resveratrol inhibits lipopolysaccharide-induced activation of osteoclast precursor Raw 264.7 cells. Acta Anatomica Sinica. 46:51–56. 2015.doi: 10.16098/j.issn.0529-1356.2015.01.009.

20 

Nurdiana N, Mariati N, Noorhamdani N, Setiawan B, Budhiparama N and Noor Z: Effects of Labisia pumila, on oxidative stress in rat model of post-menopausal osteoporosis. Asian Pac J Reprod. 5:391–394. 2016. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ren H, Sun R and Wang J: Relationship of melatonin level, oxidative stress and inflammatory status with osteoporosis in maintenance hemodialysis of chronic renal failure. Exp Ther Med 15: 5183-5188, 2018.
APA
Ren, H., Sun, R., & Wang, J. (2018). Relationship of melatonin level, oxidative stress and inflammatory status with osteoporosis in maintenance hemodialysis of chronic renal failure. Experimental and Therapeutic Medicine, 15, 5183-5188. https://doi.org/10.3892/etm.2018.5857
MLA
Ren, H., Sun, R., Wang, J."Relationship of melatonin level, oxidative stress and inflammatory status with osteoporosis in maintenance hemodialysis of chronic renal failure". Experimental and Therapeutic Medicine 15.6 (2018): 5183-5188.
Chicago
Ren, H., Sun, R., Wang, J."Relationship of melatonin level, oxidative stress and inflammatory status with osteoporosis in maintenance hemodialysis of chronic renal failure". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5183-5188. https://doi.org/10.3892/etm.2018.5857
Copy and paste a formatted citation
x
Spandidos Publications style
Ren H, Sun R and Wang J: Relationship of melatonin level, oxidative stress and inflammatory status with osteoporosis in maintenance hemodialysis of chronic renal failure. Exp Ther Med 15: 5183-5188, 2018.
APA
Ren, H., Sun, R., & Wang, J. (2018). Relationship of melatonin level, oxidative stress and inflammatory status with osteoporosis in maintenance hemodialysis of chronic renal failure. Experimental and Therapeutic Medicine, 15, 5183-5188. https://doi.org/10.3892/etm.2018.5857
MLA
Ren, H., Sun, R., Wang, J."Relationship of melatonin level, oxidative stress and inflammatory status with osteoporosis in maintenance hemodialysis of chronic renal failure". Experimental and Therapeutic Medicine 15.6 (2018): 5183-5188.
Chicago
Ren, H., Sun, R., Wang, J."Relationship of melatonin level, oxidative stress and inflammatory status with osteoporosis in maintenance hemodialysis of chronic renal failure". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5183-5188. https://doi.org/10.3892/etm.2018.5857
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team