Open Access

Nasopharyngeal carcinoma: A review of current updates

  • Authors:
    • Lei Wu
    • Churong Li
    • Li Pan
  • View Affiliations

  • Published online on: February 20, 2018     https://doi.org/10.3892/etm.2018.5878
  • Pages: 3687-3692
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Nasopharyngeal carcinoma (NPC) is a rare malignancy worldwide, but it is endemic in a few areas including Southern China, Southeast Asia, North Africa and the Arctic. The underlying mechanisms behind this remarkable geographic distribution remain unclear. Although Epstein‑Barr virus (EBV) infection has been suggested as a necessary cause of undifferentiated NPC, EBV itself is not sufficient to cause this malignancy. Other co-factors, such as environmental risk factors, and/or genetic susceptibility, may interact with EBV to play a role in the carcinogenesis of NPC. Survival rates differ significantly between NPC patients in early stages and late stages. Due to the close associations between EBV infection and NPC risk, EBV-related biomarkers have been used for early detection and screening for NPC in a few high-incidence areas. In the present review article the latest updates are discussed.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wu L, Li C and Pan L: Nasopharyngeal carcinoma: A review of current updates. Exp Ther Med 15: 3687-3692, 2018
APA
Wu, L., Li, C., & Pan, L. (2018). Nasopharyngeal carcinoma: A review of current updates. Experimental and Therapeutic Medicine, 15, 3687-3692. https://doi.org/10.3892/etm.2018.5878
MLA
Wu, L., Li, C., Pan, L."Nasopharyngeal carcinoma: A review of current updates". Experimental and Therapeutic Medicine 15.4 (2018): 3687-3692.
Chicago
Wu, L., Li, C., Pan, L."Nasopharyngeal carcinoma: A review of current updates". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3687-3692. https://doi.org/10.3892/etm.2018.5878