Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2018 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Identification of functional modules induced by bare-metal stents and paclitaxel-eluting stents in coronary heart disease

  • Authors:
    • Zhaobin Tang
    • Jingjing Gu
    • Ping Sun
    • Jing Zhao
    • Yonggang Zhao
  • View Affiliations / Copyright

    Affiliations: Cardiology Second Ward, The First Hospital of Zibo, Zibo, Shandong 255200, P.R. China, Department of Pharmacy, The Fourth People's Hospital of Zibo, Zibo, Shandong 255200, P.R. China, Medical Record Management Section, The First Hospital of Zibo, Zibo, Shandong 255200, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3801-3808
    |
    Published online on: February 20, 2018
       https://doi.org/10.3892/etm.2018.5879
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Bare-metal stents (BMS) and paclitaxel-eluting stent (PES) are frequently used in medicine for the treatment of coronary heart disease, with millions of patients treated worldwide. The protein-protein interactions (PPI) were adopted to construct the networks. The M-module algorithm was used to identify multiple differential modules. Gene Ontology enrichment and pathway enrichment analysis were performed to analyze characteristics of modules. With the PPI and microarray data, two differential co-expressed networks were constructed, module 1 indicating PES and module 2 indicating BMS, with the same genes but different edges. At a module connectivity dynamic score P-value cut-off of <0.05, module 1 was identified with 142 nodes and 460 edges and in the module 2, 73 nodes and 222 edges were identified. Significant biological processes and pathways were found different in the two modules. Through the two differential modules, we revealed the potential molecular changes induced by PES and BMS providing new insights into the underlying mechanisms in human left internal mammary arteries after inserted with a stent.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ruygrok PN and Serruys PW: Intracoronary stenting. From concept to custom. Circulation. 94:882–890. 1996. View Article : Google Scholar : PubMed/NCBI

2 

Bønaa KH, Mannsverk J, Wiseth R, Aaberge L, Myreng Y, Nygård O, Nilsen DW, Kløw NE, Uchto M, Trovik T, et al NORSTENT Investigators, : Drug-eluting or bare-metal stents for coronary artery disease. N Engl J Med. 375:1242–1252. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Serruys PW, Kutryk MJ and Ong AT: Coronary-artery stents. N Engl J Med. 354:483–495. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O'Shaughnessy C, Caputo RP, Kereiakes DJ, Williams DO, Teirstein PS, et al SIRIUS Investigators, : Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med. 349:1315–1323. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Laarman GJ, Suttorp MJ, Dirksen MT, van Heerebeek L, Kiemeneij F, Slagboom T, van der Wieken LR, Tijssen JG, Rensing BJ and Patterson M: Paclitaxel-eluting versus uncoated stents in primary percutaneous coronary intervention. N Engl J Med. 355:1105–1113. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Authors/Task Force M, ; Windecker S, Kolh P, Alfonso F, Collet JP, Cremer J, Falk V, Filippatos G, Hamm C, Head SJ, et al: 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. 35:2541–2619. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Huan T, Zhang B, Wang Z, Joehanes R, Zhu J, Johnson AD, Ying S, Munson PJ, Raghavachari N, Wang R, et al Coronary artery disease genome wide replication and meta-analysis (CARDIoGRAM) consortium, International Consortium for Blood Pressure GWAS (ICBP), : A systems biology framework identifies molecular underpinnings of coronary heart disease. Arterioscler Thromb Vasc Biol. 33:1427–1434. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Gargalovic PS, Imura M, Zhang B, Gharavi NM, Clark MJ, Pagnon J, Yang WP, He A, Truong A, Patel S, et al: Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci USA. 103:pp. 12741–12746. 2006; View Article : Google Scholar : PubMed/NCBI

9 

Akavia UD and Benayahu D: Meta-analysis and profiling of cardiac expression modules. Physiol Genomics. 35:305–315. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Segal E, Shapira M, Regev A, Pe'er D, Botstein D, Koller D and Friedman N: Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data. Nat Genet. 34:166–176. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Tanay A and Shamir R: Computational expansion of genetic networks. Bioinformatics. 17 Suppl 1:S270–S278. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Pe'er D, Regev A and Tanay A: Minreg: Inferring an active regulator set. Bioinformatics. 18 Suppl 1:S258–S267. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Ma X, Gao L, Karamanlidis G, Gao P, Lee CF, Garcia-Menendez L, Tian R and Tan K: Revealing pathway dynamics in heart diseases by analyzing multiple differential networks. PLOS Comput Biol. 11:e10043322015. View Article : Google Scholar : PubMed/NCBI

14 

Nayak RR, Kearns M, Spielman RS and Cheung VG: Coexpression network based on natural variation in human gene expression reveals gene interactions and functions. Genome Res. 19:1953–1962. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Vizeacoumar FJ, van Dyk N, Vizeacoumar F S, Cheung V, Li J, Sydorskyy Y, Case N, Li Z, Datti A, Nislow C, et al: Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis. J Cell Biol. 188:69–81. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Xiao Y, Xu C, Guan J, Ping Y, Fan H, Li Y, Zhao H and Li X: Discovering dysfunction of multiple microRNAs cooperation in disease by a conserved microRNA co-expression network. PLoS One. 7:e322012012. View Article : Google Scholar : PubMed/NCBI

17 

Ma L, Robinson LN and Towle HC: ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver. J Biol Chem. 281:28721–28730. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Rifai N and Ridker PM: Proposed cardiovascular risk assessment algorithm using high-sensitivity C-reactive protein and lipid screening. Clin Chem. 47:28–30. 2001.PubMed/NCBI

19 

Bolstad BM, Irizarry RA, Astrand M and Speed TP: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 19:185–193. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B and Speed TP: Summaries of affymetrix genechip probe level data. Nucleic Acids Res. 31:e152003. View Article : Google Scholar : PubMed/NCBI

21 

Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, Minguez P, Doerks T, Stark M, Muller J, Bork P, et al: The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 39(Database): D561–D568. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc B. 57:289–300. 1995.

23 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al The Gene Ontology Consortium, : Gene ontology: Tool for the unification of biology. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Stettler C, Wandel S, Allemann S, Kastrati A, Morice MC, Schömig A, Pfisterer ME, Stone GW, Leon MB, de Lezo JS, et al: Outcomes associated with drug-eluting and bare-metal stents: A collaborative network meta-analysis. Lancet. 370:937–948. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Miki K, Fujii K, Kawasaki D, Fukunaga M, Nishimura M, Horimatsu T, Saita T, Tamaru H, Imanaka T, Shibuya M, et al: Effect of bare-metal nitinol stent implantation and paclitaxel-eluting nitinol stent implantation on vascular response in the superficial femoral artery lesion assessed on intravascular ultrasound. Circ J. 78:1451–1458. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Taylor IW, Linding R, Warde-Farley D, Liu Y, Pesquita C, Faria D, Bull S, Pawson T, Morris Q and Wrana JL: Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nat Biotechnol. 27:199–204. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Pujana MA, Han JD, Starita LM, Stevens KN, Tewari M, Ahn JS, Rennert G, Moreno V, Kirchhoff T, Gold B, et al: Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet. 39:1338–1349. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tang Z, Gu J, Sun P, Zhao J and Zhao Y: Identification of functional modules induced by bare-metal stents and paclitaxel-eluting stents in coronary heart disease. Exp Ther Med 15: 3801-3808, 2018.
APA
Tang, Z., Gu, J., Sun, P., Zhao, J., & Zhao, Y. (2018). Identification of functional modules induced by bare-metal stents and paclitaxel-eluting stents in coronary heart disease. Experimental and Therapeutic Medicine, 15, 3801-3808. https://doi.org/10.3892/etm.2018.5879
MLA
Tang, Z., Gu, J., Sun, P., Zhao, J., Zhao, Y."Identification of functional modules induced by bare-metal stents and paclitaxel-eluting stents in coronary heart disease". Experimental and Therapeutic Medicine 15.4 (2018): 3801-3808.
Chicago
Tang, Z., Gu, J., Sun, P., Zhao, J., Zhao, Y."Identification of functional modules induced by bare-metal stents and paclitaxel-eluting stents in coronary heart disease". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3801-3808. https://doi.org/10.3892/etm.2018.5879
Copy and paste a formatted citation
x
Spandidos Publications style
Tang Z, Gu J, Sun P, Zhao J and Zhao Y: Identification of functional modules induced by bare-metal stents and paclitaxel-eluting stents in coronary heart disease. Exp Ther Med 15: 3801-3808, 2018.
APA
Tang, Z., Gu, J., Sun, P., Zhao, J., & Zhao, Y. (2018). Identification of functional modules induced by bare-metal stents and paclitaxel-eluting stents in coronary heart disease. Experimental and Therapeutic Medicine, 15, 3801-3808. https://doi.org/10.3892/etm.2018.5879
MLA
Tang, Z., Gu, J., Sun, P., Zhao, J., Zhao, Y."Identification of functional modules induced by bare-metal stents and paclitaxel-eluting stents in coronary heart disease". Experimental and Therapeutic Medicine 15.4 (2018): 3801-3808.
Chicago
Tang, Z., Gu, J., Sun, P., Zhao, J., Zhao, Y."Identification of functional modules induced by bare-metal stents and paclitaxel-eluting stents in coronary heart disease". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3801-3808. https://doi.org/10.3892/etm.2018.5879
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team