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Article

Gene expression analysis for pneumonia caused by Gram-positive bacterial infection

  • Authors:
    • Rufu Jia
    • Jingyan Yang
    • Ying Cui
    • Dongjie Guo
    • Tiejun Li
  • View Affiliations / Copyright

    Affiliations: Department of Neuroscience, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China, Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China, Department of Laboratory Medicine, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China, Teaching Office, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China
  • Pages: 3989-3996
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    Published online on: February 28, 2018
       https://doi.org/10.3892/etm.2018.5904
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Abstract

Gram-positive bacteria are an important pathogenic factor for bacterial pneumonia. The aim of the present study was to identify the differentially expressed genes (DEGs) and to explore their associated pathways or expression patterns. Expression profiling of gene arrays from two independent datasets, GSE6269 and GSE35716, were downloaded from the Gene Expression Omnibus. The DEGs between peripheral blood samples from healthy controls and patients with bacterial pneumonia were identified. The Functional Annotation Tool in the Database for Annotation, Visualization and Integrated Discovery was used to annotate and analyze the DEGs in Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Multiple proteins were used to generate a protein‑protein interaction (PPI) network. A total of 624 (621 annotated) were identified in the GSE6269 dataset and 398 (295 annotated) DEGs were identified in the GSE35716 dataset between pneumonia and healthy samples. A total of 40 common DEGs were identified between the 2 datasets, including 4 downregulated and 32 upregulated DEGs. In the GO category cellular component, melanosome was highly enriched among 11 genes; in the category biological process, the three most enriched items were regulation of ruffle assembly, negative regulation of calcium ion transport and necroptotic process. In the KEGG terms, only the nuclear factor‑κB signaling pathway (Homo sapiens 04064) was significantly enriched. In the PPI network, five genes (CCL4, TIMP metallopeptidase inhibitor 1, intercellular adhesion molecule 1, plasminogen activator, urokinase receptor and cathepsin B) were identified to have a high degree of interaction with other DEGs. In conclusion, these five genes may represent key genes associated with pneumonia caused by Gram‑positive bacteria. All of these results provide primary information and basic knowledge to understand the mechanisms of the pathogenesis.
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View References

1 

Dickson RP, Erb-Downward JR and Huffnagle GB: The role of the bacterial microbiome in lung disease. Expert Rev Respir Med. 7:245–257. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Marik PE: Aspiration pneumonitis and aspiration pneumonia. N Engl J Med. 344:665–671. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Levy SB and Marshall B: Antibacterial resistance worldwide: Causes, challenges and responses. Nat Med. 10 Suppl 12:S122–S129. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Jones RN: Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. Clin Infect Dis. 51 Suppl 1:S81–S87. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Fagon J, Patrick H, Haas DW, Torres A, Gibert C, Cheadle WG, Falcone RE, Anholm JD, Paganin F, Fabian TC and Lilienthal F: Treatment of gram-positive nosocomial pneumonia: Prospective randomized comparison of quinupristin/dalfopristin versus vancomycin. Nosocomial Pneumonia Group. Am J Respir Crit Care Med. 161:753–762. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Testa A, Giannuzzi R, Daini S, Bernardini L, Petrongolo L and Gentiloni Silveri N: Psychiatric emergencies (part III): Psychiatric symptoms resulting from organic diseases. Eur Rev Med Pharmacol Sci. 17 Suppl 1:S86–S99. 2013.

7 

Kirby WM: Treatment of bacterial pneumonia. AMA Arch Intern Med. 96:809–817. 1955. View Article : Google Scholar : PubMed/NCBI

8 

Burwen DR, Banerjee SN and Gaynes RP: Ceftazidime resistance among selected nosocomial gram-negative bacilli in the United States. National nosocomial infections surveillance system. J Infect Dis. 170:1622–1625. 1994. View Article : Google Scholar : PubMed/NCBI

9 

El Moujaber G, Osman M, Rafei R, Dabboussi F and Hamze M: Molecular mechanisms and epidemiology of resistance in Streptococcus pneumoniae in the middle east region. J Med Microbiol. 66:847–858. 2017. View Article : Google Scholar

10 

Lee HY, Wu TL, Su LH, Li HC, Janapatla RP, Chen CL and Chiu CH: Invasive pneumococcal disease caused by ceftriaxone-resistant Streptococcus pneumoniae in Taiwan. J Microbiol Immunol Infect. Jun–26;2017.(Epub ahead of print). View Article : Google Scholar

11 

Yusef D, Shalakhti T, Awad S, Algharaibeh H and Khasawneh W: Clinical characteristics and epidemiology of sepsis in the neonatal intensive care unit in the era of multi-drug resistant organisms: A retrospective review. Pediatr Neonatol. Jun 9–2017.(Epub ahead of print).

12 

Karlowsky JA, Thornsberry C, Jones ME, Evangelista AT, Critchley IA and Sahm DF: TRUST Surveillance Program: Factors associated with relative rates of antimicrobial resistance among Streptococcus pneumoniae in the United States: Results from the TRUST surveillance program (1998–2002). Clin Infect Dis. 36:963–970. 2003. View Article : Google Scholar

13 

Kajikawa O, Frevert CW, Lin SM, Goodman RB, Mongovin SM, Wong V, Ballman K, Daubeuf B, Elson G and Martin TR: Gene expression of Toll-like receptor-2, Toll-like receptor-4, and MD2 is differentially regulated in rabbits with Escherichia coli pneumonia. Gene. 344:193–202. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Ramilo O, Allman W, Chung W, Mejias A, Ardura M, Glaser C, Wittkowski KM, Piqueras B, Banchereau J, Palucka AK and Chaussabel D: Gene expression patterns in blood leukocytes discriminate patients with acute infections. Blood. 109:2066–2077. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Levy H, Wang X, Kaldunski M, Jia S, Kramer J, Pavletich SJ, Reske M, Gessel T, Yassai M, Quasney MW, et al: Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes. Genes Immun. 13:593–604. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Heber S and Sick B: Quality assessment of Affymetrix GeneChip data. OMICS. 10:358–68. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Wu C, Irizarry R and Gentry J: gcrma: Background adjustment using sequence information. 2005.

18 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

19 

Wickham H: ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag; New York: 2009, View Article : Google Scholar

20 

Chen H and Boutros PC: VennDiagram: A package for the generation of highly-customizable Venn and Euler diagrams in R. BMC Bioinformatics. 12:352011. View Article : Google Scholar : PubMed/NCBI

21 

Kolde R: pheatmap. In: Pretty Heatmaps. R package version 1.0.2, 2015. https://cran.r-project.org/web/packages/pheatmap/pheatmap.pdfJune 12–2016

22 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Alishahi K, Ehyaei AR and Shojaie A: A generalized benjamini-hochberg procedure for multivariate hypothesis testing. Methodology. 33:2016.

24 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43:(Database issue). D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Mandourah Y, Al-Radi A, Ocheltree AH, Ocheltree SR and Fowler RA: Clinical and temporal patterns of severe pneumonia causing critical illness during Hajj. BMC Infect Dis. 12:1172012. View Article : Google Scholar : PubMed/NCBI

26 

Cilloniz C, Martin-Loeches I, Garcia-Vidal C, San Jose A and Torres A: Microbial etiology of pneumonia: Epidemiology, diagnosis and resistance patterns. Int J Mol Sci. 17:E21202016. View Article : Google Scholar : PubMed/NCBI

27 

Osiyemi O and Dickinson G: Gram-positive pneumonia. Curr Infect Dis Rep. 2:207–214. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Scannapieco FA: Role of oral bacteria in respiratory infection. J Periodontol. 70:793–802. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Garibaldi RA: Epidemiology of community-acquired respiratory tract infections in adults: Incidence, etiology and impact. Am J Med. 78:32–37. 1985. View Article : Google Scholar : PubMed/NCBI

30 

Guan E, Wang J, Roderiquez G and Norcross MA: Natural truncation of the chemokine MIP-1 beta/CCL4 affects receptor specificity but not anti-HIV-1 activity. J Biol Chem. 277:32348–32352. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Luther SA and Cyster JG: Chemokines as regulators of T cell differentiation. Nat Immunol. 2:102–107. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Guan E, Wang J and Norcross MA: Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer. J Biol Chem. 276:12404–12409. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Carlson M, Nakamura Y, Payson R, O'Connell P, Leppert M, Lathrop GM, Lalouel JM and White R: Isolation and mapping of a polymorphic DNA sequence (pMCT108.2) on chromosome 18 [D18S24]. Nucleic Acids Res. 16:41881988. View Article : Google Scholar : PubMed/NCBI

34 

Katz FE, Parkar M, Stanley K, Murray LJ, Clark EA and Greaves MF: Chromosome mapping of cell membrane antigens expressed on activated B cells. Eur J Immunol. 15:103–106. 1985. View Article : Google Scholar : PubMed/NCBI

35 

Murdoch C, Read RC, Zhang Q and Finn A: Choline-binding protein A of Streptococcus pneumoniae elicits chemokine production and expression of intercellular adhesion molecule 1 (CD54) by human alveolar epithelial cells. J Infect Dis. 186:1253–1260. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Shapiro S, Miller A, Lahat N, Sobel E and Lerner A: Expression of matrix metalloproteinases, sICAM-1 and IL-8 in CSF from children with meningitis. J Neurol Sci. 206:43–48. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Brew K and Nagase H: The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity. Biochim Biophys Acta. 1803:55–71. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Ylisirniö S, Höyhtyä M and Turpeenniemi-Hujanen T: Serum matrix metalloproteinases-2, −9 and tissue inhibitors of metalloproteinases-1, −2 in lung cancer-TIMP-1 as a prognostic marker. Anticancer Res. 20:1311–1316. 2000.PubMed/NCBI

39 

Fong KM, Kida Y, Zimmerman PV and Smith PJ: TIMP1 and adverse prognosis in non-small cell lung cancer. Clin Cancer Res. 2:1369–1372. 1996.PubMed/NCBI

40 

Wu ZS, Wu Q, Yang JH, Wang HQ, Ding XD, Yang F and Xu XC: Prognostic significance of MMP-9 and TIMP-1 serum and tissue expression in breast cancer. Int J Cancer. 122:2050–2056. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Jiang Z, Sui T and Wang B: Relationships between MMP-2, MMP-9, TIMP-1 and TIMP-2 levels and their pathogenesis in patients with lupus nephritis. Rheumatol Int. 30:1219–1226. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Kim H, Oda T, López-Guisa J, Wing D, Edwards DR, Soloway PD and Eddy AA: TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy. J Am Soc Nephrol. 12:736–748. 2001.PubMed/NCBI

43 

Kakugawa T, Mukae H, Saito M, Ishii K, Ishimoto H, Sakamoto N, Takazono T, Fukuda Y, Ooe N and Kohno S: Rapidly progressive interstitial pneumonia associated with clinically amyopathic dermatomyositis successfully treated with polymyxin B-immobilized fiber column hemoperfusion. Intern Med. 47:785–790. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Vissers M, Hartman Y, Groh L, de Jong DJ, de Jonge MI and Ferwerda G: Recognition of Streptococcus pneumoniae and muramyl dipeptide by NOD2 results in potent induction of MMP-9, which can be controlled by lipopolysaccharide stimulation. Infect Immun. 82:4952–4958. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Chan SJ, San Segundo B, McCormick MB and Steiner DF: Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. Proc Natl Acad Sci USA. 83:7721–7725. 1986. View Article : Google Scholar : PubMed/NCBI

46 

Cao L, Taggart RT, Berquin IM, Moin K, Fong D and Sloane BF: Human gastric adenocarcinoma cathepsin B: Isolation and sequencing of full-length cDNAs and polymorphisms of the gene. Gene. 139:163–169. 1994. View Article : Google Scholar : PubMed/NCBI

47 

Foghsgaard L, Lademann U, Wissing D, Poulsen B and Jaattela M: Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells. J Biol Chem. 277:39499–39506. 2002. View Article : Google Scholar : PubMed/NCBI

48 

Borgfeldt C, Bendahl PO, Gustavsson B, Långström E, Fernö M, Willén R, Grenman S and Casslén B: High tumor tissue concentration of urokinase plasminogen activator receptor is associated with good prognosis in patients with ovarian cancer. Int J Cancer. 107:658–665. 2003. View Article : Google Scholar : PubMed/NCBI

49 

Chavakis T, Kanse SM, May AE and Preissner KT: Haemostatic factors occupy new territory: The role of the urokinase receptor system and kininogen in inflammation. Biochem Soc Trans. 30:168–173. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jia R, Yang J, Cui Y, Guo D and Li T: Gene expression analysis for pneumonia caused by Gram-positive bacterial infection. Exp Ther Med 15: 3989-3996, 2018.
APA
Jia, R., Yang, J., Cui, Y., Guo, D., & Li, T. (2018). Gene expression analysis for pneumonia caused by Gram-positive bacterial infection. Experimental and Therapeutic Medicine, 15, 3989-3996. https://doi.org/10.3892/etm.2018.5904
MLA
Jia, R., Yang, J., Cui, Y., Guo, D., Li, T."Gene expression analysis for pneumonia caused by Gram-positive bacterial infection". Experimental and Therapeutic Medicine 15.4 (2018): 3989-3996.
Chicago
Jia, R., Yang, J., Cui, Y., Guo, D., Li, T."Gene expression analysis for pneumonia caused by Gram-positive bacterial infection". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3989-3996. https://doi.org/10.3892/etm.2018.5904
Copy and paste a formatted citation
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Spandidos Publications style
Jia R, Yang J, Cui Y, Guo D and Li T: Gene expression analysis for pneumonia caused by Gram-positive bacterial infection. Exp Ther Med 15: 3989-3996, 2018.
APA
Jia, R., Yang, J., Cui, Y., Guo, D., & Li, T. (2018). Gene expression analysis for pneumonia caused by Gram-positive bacterial infection. Experimental and Therapeutic Medicine, 15, 3989-3996. https://doi.org/10.3892/etm.2018.5904
MLA
Jia, R., Yang, J., Cui, Y., Guo, D., Li, T."Gene expression analysis for pneumonia caused by Gram-positive bacterial infection". Experimental and Therapeutic Medicine 15.4 (2018): 3989-3996.
Chicago
Jia, R., Yang, J., Cui, Y., Guo, D., Li, T."Gene expression analysis for pneumonia caused by Gram-positive bacterial infection". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3989-3996. https://doi.org/10.3892/etm.2018.5904
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