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miR-143-3p regulates cell proliferation and apoptosis by targeting IGF1R and IGFBP5 and regulating the Ras/p38 MAPK signaling pathway in rheumatoid arthritis

  • Authors:
    • Zhenguo Yang
    • Jifu Wang
    • Zhuangzhuang Pan
    • Yihang Zhang

  • View Affiliations

  • Published online on: February 28, 2018     https://doi.org/10.3892/etm.2018.5907
  • Pages: 3781-3790

  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It has been demonstrated that the deregulation of microRNAs (miRNAs) affects the development of rheumatoid arthritis (RA). The primary objective of the current study was to determine the role of miR‑143‑3p in the progression of RA. The expression of miR‑143‑3p in synovium taken from patients with RA was assessed by reverse transcription‑quantitative polymerase chain reaction. The expression of miR‑143‑3p was higher in synovium tissues of RA than that of osteoarthritis (OA). The decreased expression of miR‑143‑3p suppressed cell proliferation and promoted apoptosis in vitro. In addition, inhibition of miR‑143‑3p decreased levels of inflammatory cytokines, as determined by an enzyme‑linked immunosorbent assay. IGF1R and IGFBP5 were found to be the target genes of miR‑143‑3p, and it was demonstrated that miR‑143‑3p regulated the proliferation and apoptosis of MH7A cells by targeting IGF1R and IGFBP5. Furthermore, TNF‑α treatment stimulated the Ras/p38 mitogen activated protein kinase (MAPK) signaling pathway, whereas miR‑143‑3p inhibition suppressed it. The results of the current study indicate that miR‑143‑3p may regulate cell proliferation and apoptosis by targeting IGF1R and IGFBP5 expression and regulating the Ras/p38 MAPK signaling pathways. Therefore, miR‑143‑3p may be a novel therapeutic target in RA.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yang Z, Wang J, Pan Z and Zhang Y: miR-143-3p regulates cell proliferation and apoptosis by targeting IGF1R and IGFBP5 and regulating the Ras/p38 MAPK signaling pathway in rheumatoid arthritis. Exp Ther Med 15: 3781-3790, 2018
APA
Yang, Z., Wang, J., Pan, Z., & Zhang, Y. (2018). miR-143-3p regulates cell proliferation and apoptosis by targeting IGF1R and IGFBP5 and regulating the Ras/p38 MAPK signaling pathway in rheumatoid arthritis. Experimental and Therapeutic Medicine, 15, 3781-3790. https://doi.org/10.3892/etm.2018.5907
MLA
Yang, Z., Wang, J., Pan, Z., Zhang, Y."miR-143-3p regulates cell proliferation and apoptosis by targeting IGF1R and IGFBP5 and regulating the Ras/p38 MAPK signaling pathway in rheumatoid arthritis". Experimental and Therapeutic Medicine 15.4 (2018): 3781-3790.
Chicago
Yang, Z., Wang, J., Pan, Z., Zhang, Y."miR-143-3p regulates cell proliferation and apoptosis by targeting IGF1R and IGFBP5 and regulating the Ras/p38 MAPK signaling pathway in rheumatoid arthritis". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3781-3790. https://doi.org/10.3892/etm.2018.5907