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Rat vibrissa dermal papilla cells promote healing of spinal cord injury following transplantation

  • Authors:
    • Meiying Li
    • Xianglin Mei
    • Shuang Lv
    • Zechuan Zhang
    • Jinying Xu
    • Dongjie Sun
    • Jiayi Xu
    • Xia He
    • Guangfan Chi
    • Yulin Li
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, Jilin 130021, P.R. China, Department of Pathology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Clinical Medical College, Jilin University, Changchun, Jilin 130021, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3929-3939
    |
    Published online on: February 28, 2018
       https://doi.org/10.3892/etm.2018.5916
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Abstract

Bone marrow mesenchymal stem cell (BMSC) transplantation is effective for repairing spinal cord injuries (SCIs); however, there are limitations of clinical BMSC applications. Previously, we reported that dermal papilla cells (DPCs) secrete brain‑derived neurotrophic factor and glial cell line‑derived neurotrophic factor more actively than BMSCs. To analyze the therapeutic function of DPCs in SCI, primary DPCs and BMSCs were cultured from the same green fluorescence protein-transgenic rat. The cells were suspended in rat‑tail collagen I and transplanted separately into completely transected spinal cord lesion sites. Grafted‑cell survival was examined with a small animal in vivo imaging detection system, and lesion sites were examined histochemically. In vivo imaging revealed enhanced lesion filling and survival with DPC grafts compared with BMSC grafts on days 14 and 21 post‑transplantation. Hematoxylin and eosin staining demonstrated that lesion area sizes in the two groups were not markedly different. In the DPC transplant group, more axons formed within the lesion sites. CD31‑positive vessel‑like structures were more abundant in lesion sites near the grafted cells in the DPC group. The results of the present study suggest that DPCs may be a valuable alternative source of stem cells for autologous cell therapy for the treatment of SCI.
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Copy and paste a formatted citation
Spandidos Publications style
Li M, Mei X, Lv S, Zhang Z, Xu J, Sun D, Xu J, He X, Chi G, Li Y, Li Y, et al: Rat vibrissa dermal papilla cells promote healing of spinal cord injury following transplantation. Exp Ther Med 15: 3929-3939, 2018.
APA
Li, M., Mei, X., Lv, S., Zhang, Z., Xu, J., Sun, D. ... Li, Y. (2018). Rat vibrissa dermal papilla cells promote healing of spinal cord injury following transplantation. Experimental and Therapeutic Medicine, 15, 3929-3939. https://doi.org/10.3892/etm.2018.5916
MLA
Li, M., Mei, X., Lv, S., Zhang, Z., Xu, J., Sun, D., Xu, J., He, X., Chi, G., Li, Y."Rat vibrissa dermal papilla cells promote healing of spinal cord injury following transplantation". Experimental and Therapeutic Medicine 15.4 (2018): 3929-3939.
Chicago
Li, M., Mei, X., Lv, S., Zhang, Z., Xu, J., Sun, D., Xu, J., He, X., Chi, G., Li, Y."Rat vibrissa dermal papilla cells promote healing of spinal cord injury following transplantation". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3929-3939. https://doi.org/10.3892/etm.2018.5916
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Mei X, Lv S, Zhang Z, Xu J, Sun D, Xu J, He X, Chi G, Li Y, Li Y, et al: Rat vibrissa dermal papilla cells promote healing of spinal cord injury following transplantation. Exp Ther Med 15: 3929-3939, 2018.
APA
Li, M., Mei, X., Lv, S., Zhang, Z., Xu, J., Sun, D. ... Li, Y. (2018). Rat vibrissa dermal papilla cells promote healing of spinal cord injury following transplantation. Experimental and Therapeutic Medicine, 15, 3929-3939. https://doi.org/10.3892/etm.2018.5916
MLA
Li, M., Mei, X., Lv, S., Zhang, Z., Xu, J., Sun, D., Xu, J., He, X., Chi, G., Li, Y."Rat vibrissa dermal papilla cells promote healing of spinal cord injury following transplantation". Experimental and Therapeutic Medicine 15.4 (2018): 3929-3939.
Chicago
Li, M., Mei, X., Lv, S., Zhang, Z., Xu, J., Sun, D., Xu, J., He, X., Chi, G., Li, Y."Rat vibrissa dermal papilla cells promote healing of spinal cord injury following transplantation". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3929-3939. https://doi.org/10.3892/etm.2018.5916
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