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Protective effect of Atriplex suberecta extract against oxidative and apoptotic hepatotoxicity

  • Authors:
    • Mohammad K. Parvez
    • Ahmad H. Arbab
    • Mohammed S. Al‑Dosari
    • Adnan J. Al‑Rehaily
    • Perwez Alam
    • Khalid E. Ibrahim
    • Mansour S. Alsaid
    • Syed Rafatullah
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia, Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia, Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Copyright: © Parvez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3883-3891
    |
    Published online on: March 2, 2018
       https://doi.org/10.3892/etm.2018.5919
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Abstract

Atriplex suberecta I. Verd is a known phytomedicinal species of Atriplex; however, studies into its bioactivity remain inconclusive. The in vitro and in vivo antioxidative and hepatoprotective potential of A. suberecta ethanol‑extract (ASEE) was assessed in the present study. 1,1‑diphenyl‑2‑picrylhydrazyl radical scavenging and β‑carotene bleaching assays revealed that ASEE possesses free radical scavenging and anti‑lipid peroxidative activities. These results were supported by the in vitro protection of HepG2 hepatoblastoma cells via abating 2,7‑dichlorofluorescein‑activated oxidative and apoptotic molecules (caspase‑3/‑7). In carbon tetrachloride‑treated rats, the oral administration of ASEE significantly normalized serum biomarkers of liver function (serum glutamate oxaloacetate, serum pyruvate transaminase, alkaline phosphatase, γ‑glutamyl transferase and bilirubin) and the lipid profile (total cholesterol, high‑density lipoprotein, low‑density lipoprotein, triglycerides and malondialdehyde), including tissue non‑protein sulfhydryl and total protein levels. These results were also supported by liver histopathology, which demonstrated that the therapeutic effect of ASEE was comparable to silymarin. Furthermore, phytochemical analysis of ASEE revealed the presence of flavonoids, alkaloids, tannins and saponins. Rutin, an antioxidant flavonoid, was identified using the validated high‑performance thin‑layer chromatography method. In conclusion, this is the first report on the therapeutic potential of A. suberecta against chemical‑induced oxidative stress and liver damage.
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1 

Williams R: Global challenges in liver disease. Hepatology. 44:521–526. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Aniya Y, Koyama T, Miyagi C, Miyahira M, Inomata C, Kinoshita S and Ichiba T: Free radical scavenging and hepatoprotective actions of the medicinal herb, Crassocephalum crepidioides from the Okinawa Islands. Biol Pharm Bull. 28:19–23. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Farghali H, Canová NK and Zakhari S: Hepatoprotective properties of extensively studied medicinal plant active constituents: Possible common mechanisms. Pharm Biol. 53:781–791. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Katikova Olu, Kostin IaV and Tishkin VS: Hepatoprotective effect of plant preparations. Eksp Klin Farmakol. 65:41–43. 2002.(In Russian). PubMed/NCBI

5 

Ahmad N, Fazal H, Abbasi BH, Anwar S and Basir A: DPPH free radical scavenging activity and phenotypic difference in hepatoprotective plant (Silybum marianum L.). Toxicol Ind Health. 29:460–467. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Olalye MT and Rocha JB: Commonly used tropical medicinal plants exhibit distinct in vitro antioxidant activities against hepatotoxins in rat liver. Exp Toxicol Pathol. 58:433–438. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Le Houerou HN: The role of saltbushes (Atriplex spp.) in arid land rehabilitation in the Mediterranean Basin: A review. Agroforest Sys. 18:107–148. 1992. View Article : Google Scholar

8 

Khalil JK, Sawaya WN and Hyder SZ: Nutrient composition of Αtriplex leaves grown in Saudi-Arabia. J Range Manage. 39:104–107. 1986. View Article : Google Scholar

9 

Walker DJ, Lutts S, Sánchez-García M and Correal E: Atriplex halimus L.: Its biology and uses. J Arid Environ. 100:111–121. 2001.

10 

Fernández SS, Padilla AP and Mucciarelli S: Protein extraction from Atriplex lampa leaves: Potential use as forage for animals used for human diets. Plant Foods Hum Nutr. 54:251–259. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Rolleston JD: I. The folk-lore of venereal disease. Br J Vener Dis. 18:1–13. 1942.PubMed/NCBI

12 

Said O, Fulder S, Khalil K, Azaizeh H, Kassis E and Said B: Maintaining a physiological blood glucose level with ‘Glucolevel’, a combination of four anti-diabetes plants used in the traditional arab herbal medicine. Evid Based Complement Alternat Med. 5:421–428. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Abdel Rahman SM, Abd-Ellatif SA, Deraz SF and Khalil AA: Antibacterial activity of some wild medicinal plants collected from western Mediterranean coast, Egypt: Natural alternatives for infectious disease treatment. Afr J Biotechnol. 10:10733–10743. 2011. View Article : Google Scholar

14 

Clauser M, Dall'Acqua S, Loi MC and Innocenti G: Phytochemical investigation on Atriplex halimus L. from Sardinia. Nat Prod Res. 27:1940–1944. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Ali B, Tabassum R, Riaz N, Yaqoob A, Khatoon T, Tareen RB, Jabbar A, Nasim FU and Saleem M: Bioactive triterpenoids from Atriplex lasiantha. J Asian Nat Prod Res. 17:843–850. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Kamal Z, Ullah F, Ayaz M, Sadiq A, Ahmad S, Zeb A, Hussain A and Imran M: Anticholinesterase and antioxidant investigations of crude extracts, subsequent fractions, saponins and flavonoids of Atriplex laciniata L.: Potential effectiveness in Alzheimer's and other neurological disorders. Biol Res. 48:212015. View Article : Google Scholar : PubMed/NCBI

17 

Boughalleb N, Trabelsi L and Harzallah-Skhiri F: Antifungal activity from polar and non-polar extracts of some Chenopodiaceae wild species growing in Tunisia. Nat Prod Res. 23:988–997. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Hamed N, Njeh F, Damak M, Ayadi A, Mezghani-Jarraya R and Hammami H: Molluscicidal and larvicidal activities of Atriplex inflata aerial parts against the mollusk Galba truncatula, intermediate host of Fasciola hepatica. Rev Inst Med Trop Sao Paulo. 57:473–479. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Gođevac D, Stanković J, Novaković M, Anđelković B, Dajić-Stevanović Z, Petrović M and Stanković M: Phenolic compounds from Atriplex littoralis and their radiation-mitigating activity. J Nat Prod. 78:2198–2204. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Al-Turki TA, Omer S and Ghafoor A: A synopsis of the genus Atriplex L. (Chenopodiaceae) in Saudi Arabia. Feddes Repertorium. 111:261–293. 2000. View Article : Google Scholar

21 

Cid JA, Petenatti E, Arellano M, Muzaber J and de Mucciarelli SL: Biological value of protein from leaves of Atriplex suberecta. Arch Latinoam Nutr. 41:421–427. 1991.(In Spanish). PubMed/NCBI

22 

López-Terrada D, Cheung SW, Finegold MJ and Knowles BB: HepG2 is a hepatoblastoma-derived cell line. Hum Pathol. 40:1512–1515. 2009. View Article : Google Scholar

23 

Lee YJ, Kim DB, Lee J, Cho JH, Kim B, Choi HS, Lee BY and Lee OH: Antioxidant activity and anti-adipogenic effects of wild herbs mainly cultivated in Korea. Molecules. 18:12937–12950. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Miller HE: A simplified method for the evaluation of antioxidants. J Am Oil Chem Soc. 48:911971. View Article : Google Scholar

25 

Arbab AH, Parvez MK, Al-Dosari MS, Al-Rehaily AJ, Al-Sohaibani M, Zaroug EE, AlSaid MS and Rafatullah S: Hepatoprotective and antiviral efficacy of Acacia mellifera leaves fractions against hepatitis B virus. Biomed Res Int. 2015:9291312015. View Article : Google Scholar : PubMed/NCBI

26 

Parveen R, Baboota S, Ali J, Ahuja A, Vasudev SS and Ahmad S: Effects of silymarin nanoemulsion against carbon tetrachloride-induced hepatic damage. Arch Pharm Res. 34:767–774. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Utley HG, Bernheim F and Hochstein P: Effect of sulfhydryl reagents on peroxidation in microsomes. Arch Biochem Biophys. 18:29–32. 1967. View Article : Google Scholar

28 

Sedlak J and Lindsay RH: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 25:192–205. 1968. View Article : Google Scholar : PubMed/NCBI

29 

Culling CF: Handbook of Histopathological and Histochemical Techniques. 3rd. Butterworth-Heinemann, Oxford, UK: 1974

30 

Satyajit D, Sarkar ZL and Gray AI: Natural Products Isolation. 2nd edition. Humana Press; Totowa, NJ; 2006

31 

Kar A: Pharmacognosy and Pharmacobiotechnology. (2nd). New Age International. (New Delhi, India). 2007.

32 

Tiwari P, Mandeep BK, Kaur KG and Kaur H: Phytochemical screening and extraction: A review. Interl Pharma Sci. 1:98–1062. 2011.

33 

Alam P, Parvez MK, Arbab AH and Al-Dosari MS: Quantitative analysis of rutin, quercetin, naringenin and gallic acid by validated RP- and NP-HPTLC methods for the quality control of anti-HBV active extract of Guiera senegalensis. Phrm Biol. 55:1317–1323. 2017. View Article : Google Scholar

34 

Wang Z, Li Z, Ye Y, Xie L and Li W: Oxidative stress and liver cancer: Etiology and therapeutic targets. Oxid Med Cell Long. 2016:78915742016.

35 

Rahman K: Studies on free-radicals, antioxidants, and co-factors. Clin Interven Aging. 2:219–236. 2007.

36 

Kedare SB and Singh RP: Genesis and development of DPPH method of antioxidant assay. J Food Sci Technol. 48:412–422. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Kabbash A and Shoeib N: Chemical and biological investigation of some secondary metabolites in Atriplex halimus growing in Egypt. Nat Prod Commun. 7:1465–1468. 2012.PubMed/NCBI

38 

Ben Nejma A, Nguir A, Ben Jannet H, Hamza MA, Daïch A, Othman M and Lawson AM: New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities. Bioorg Med Chem Lett. 25:1665–1670. 2015. View Article : Google Scholar

39 

Rota C, Chignell CF and Mason RP: Evidence for free radical formation during the oxidation of 2′-7′-dichlorofluorescin to the fluorescent dye 2′-7′-dichlorofluorescein by horseradish peroxidase: Possible implications for oxidative stress measurements. Free Radic Biol Med. 27:873–881. 1999. View Article : Google Scholar : PubMed/NCBI

40 

Tirkey N, Pilkhwal S, Kuhad A and Chopra K: Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. BMC Pharmacol. 5:22005. View Article : Google Scholar : PubMed/NCBI

41 

Awaad AS, Maitland DJ, Donia AR, Alqasoumi SI and Soliman GA: Novel flavonoids with antioxidant activity from a Chenopodiaceous plant. Pharm Biol. 50:99–104. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Suhail M, Suhail S, Gupta BK and Bharat V: Malondialdehyde and antioxidant enzymes in maternal and cord blood, and their correlation in normotensive and preeclamptic women. J Clin Med Res. 1:150–157. 2009.PubMed/NCBI

43 

Janbaz KH, Saeed SA and Gilani AH: Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents. Fitoterapia. 73:557–563. 2002. View Article : Google Scholar : PubMed/NCBI

44 

Hosseinzadeh H and Nassiri-Asl M: Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid. J Endocrinol Invest. 37:783–788. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Domitrović R, Jakovac H, Vasiljev Marchesi V, Vladimir-Knežević S, Cvijanović O, Tadić Z, Romić Z and Rahelić D: Differential hepatoprotective mechanisms of rutin and quercetin in CCl(4)-intoxicated BALB/cN mice. Acta Pharmacol Sin. 33:1260–1270. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Parvez MK, Arbab AH, Al‑Dosari MS, Al‑Rehaily AJ, Alam P, Ibrahim KE, Alsaid MS and Rafatullah S: Protective effect of Atriplex suberecta extract against oxidative and apoptotic hepatotoxicity. Exp Ther Med 15: 3883-3891, 2018.
APA
Parvez, M.K., Arbab, A.H., Al‑Dosari, M.S., Al‑Rehaily, A.J., Alam, P., Ibrahim, K.E. ... Rafatullah, S. (2018). Protective effect of Atriplex suberecta extract against oxidative and apoptotic hepatotoxicity. Experimental and Therapeutic Medicine, 15, 3883-3891. https://doi.org/10.3892/etm.2018.5919
MLA
Parvez, M. K., Arbab, A. H., Al‑Dosari, M. S., Al‑Rehaily, A. J., Alam, P., Ibrahim, K. E., Alsaid, M. S., Rafatullah, S."Protective effect of Atriplex suberecta extract against oxidative and apoptotic hepatotoxicity". Experimental and Therapeutic Medicine 15.4 (2018): 3883-3891.
Chicago
Parvez, M. K., Arbab, A. H., Al‑Dosari, M. S., Al‑Rehaily, A. J., Alam, P., Ibrahim, K. E., Alsaid, M. S., Rafatullah, S."Protective effect of Atriplex suberecta extract against oxidative and apoptotic hepatotoxicity". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3883-3891. https://doi.org/10.3892/etm.2018.5919
Copy and paste a formatted citation
x
Spandidos Publications style
Parvez MK, Arbab AH, Al‑Dosari MS, Al‑Rehaily AJ, Alam P, Ibrahim KE, Alsaid MS and Rafatullah S: Protective effect of Atriplex suberecta extract against oxidative and apoptotic hepatotoxicity. Exp Ther Med 15: 3883-3891, 2018.
APA
Parvez, M.K., Arbab, A.H., Al‑Dosari, M.S., Al‑Rehaily, A.J., Alam, P., Ibrahim, K.E. ... Rafatullah, S. (2018). Protective effect of Atriplex suberecta extract against oxidative and apoptotic hepatotoxicity. Experimental and Therapeutic Medicine, 15, 3883-3891. https://doi.org/10.3892/etm.2018.5919
MLA
Parvez, M. K., Arbab, A. H., Al‑Dosari, M. S., Al‑Rehaily, A. J., Alam, P., Ibrahim, K. E., Alsaid, M. S., Rafatullah, S."Protective effect of Atriplex suberecta extract against oxidative and apoptotic hepatotoxicity". Experimental and Therapeutic Medicine 15.4 (2018): 3883-3891.
Chicago
Parvez, M. K., Arbab, A. H., Al‑Dosari, M. S., Al‑Rehaily, A. J., Alam, P., Ibrahim, K. E., Alsaid, M. S., Rafatullah, S."Protective effect of Atriplex suberecta extract against oxidative and apoptotic hepatotoxicity". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3883-3891. https://doi.org/10.3892/etm.2018.5919
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