Open Access

Leptin, hs-CRP, IL-18 and urinary protein before and after treatment of children with nephrotic syndrome

  • Authors:
    • Jiayun Zhou
    • Feng Shi
    • Wenlong Xun
  • View Affiliations

  • Published online on: March 5, 2018     https://doi.org/10.3892/etm.2018.5923
  • Pages: 4426-4430
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

We aimed to analyze the changes in plasma leptin, serum inflammatory factors and urinary protein in children with nephrotic syndrome before and after treatment and their clinical significance. A total of 28 children treated and diagnosed with nephrotic syndrome between November 2015 and October 2016 were selected as treatment group, while 25 healthy children were selected as control group. There were no statistically significant differences in age, sex, body mass index (BMI), serum albumin and other general data between treatment group and control group (P>0.05). There was a positive correlation between serum high-sensitivity C-reactive protein (hs-CRP) level and 24 h urinary protein level in children with nephrotic syndrome before treatment (r=0.408, P=0.005). Twenty-four hours urinary protein, urea nitrogen (BUN) and serum creatinine (SCr) levels in children with nephrotic syndrome before treatment were significantly higher than those in normal children, and these indexes were significantly decreased after treatment. The levels of plasma leptin and serum inflammatory factors (hs-CRP and IL-18) in children with nephrotic syndrome before treatment were obviously higher than those in normal children, and these indexes were obviously decreased after treatment. In conclusion, the detection of changes in plasma leptin, serum inflammatory factors (hs-CRP and IL-18) and urinary protein in children with nephrotic syndrome before and after treatment has important reference value for reflecting the severity of disease and evaluating the prognosis of children with nephrotic syndrome.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhou J, Shi F and Xun W: Leptin, hs-CRP, IL-18 and urinary protein before and after treatment of children with nephrotic syndrome. Exp Ther Med 15: 4426-4430, 2018
APA
Zhou, J., Shi, F., & Xun, W. (2018). Leptin, hs-CRP, IL-18 and urinary protein before and after treatment of children with nephrotic syndrome. Experimental and Therapeutic Medicine, 15, 4426-4430. https://doi.org/10.3892/etm.2018.5923
MLA
Zhou, J., Shi, F., Xun, W."Leptin, hs-CRP, IL-18 and urinary protein before and after treatment of children with nephrotic syndrome". Experimental and Therapeutic Medicine 15.5 (2018): 4426-4430.
Chicago
Zhou, J., Shi, F., Xun, W."Leptin, hs-CRP, IL-18 and urinary protein before and after treatment of children with nephrotic syndrome". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4426-4430. https://doi.org/10.3892/etm.2018.5923