Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Aberrant expression of miR-663 and transforming growth factor-β1 in nasal polyposis in children

  • Authors:
    • Hailing Yu
    • Jianbao Ju
    • Jingdong Liu
    • Da Li
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, The Women and Children's Hospital of Qingdao, Qingdao, Shandong 266033, P.R. China, Department of Otolaryngology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266033, P.R. China, Department of Medicine, The Women and Children's Hospital of Qingdao, Qingdao, Shandong 266033, P.R. China
  • Pages: 4550-4556
    |
    Published online on: March 6, 2018
       https://doi.org/10.3892/etm.2018.5927
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the expression of microRNA (miR)‑663 and its regulatory effects on the pathogenesis of nasal polyposis in children. Nasal polyp tissue, as well as serum and peripheral blood eosinophils were collected from 35 children diagnosed with nasal polypectomy between August 2013 and August 2015. As a control, the inferior nasal concha, serum and peripheral blood eosinophils were collected from 46 patients with nasal septal deviation complicated by inferior turbinate hypertrophy or patients with simple inferior turbinate hypertrophy who had undergone surgical removal of the inferior nasal concha. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to measure the expression of miR‑663 and transforming growth factor‑β1 (TGF‑β1) in the nasal polyp tissue, serum and peripheral blood eosinophils of patients with nasal polyposis and controls. Western blotting was used to measure the expression of TGF‑β1 protein in nasal tissue and eosinophils and an enzyme‑linked immunosorbent assay was used to measure serum level of TGF‑β1 protein. A dual luciferase reporter assay was used to determine whether TGF‑β1 was a target gene of miR‑663. Compared with the control group, levels of TGF‑β1 mRNA and protein were significantly increased in all three types of specimens from pediatric patients with nasal polyposis (P<0.05). miR‑663 expression was significantly decreased in nasal polyp tissue and peripheral blood eosinophils (P<0.05). The dual luciferase reporter assay confirmed that TGF‑β1 was a target gene of miR‑663. The current study suggests that the upregulation of TGF‑β1 may be associated with the downregulation of miR‑663 in nasal polyposis in children. miR‑663 may have regulatory effects on the pathogenesis of nasal polyposis by regulating TGF‑β1 and may be developed as a genetic marker of nasal polyposis in children.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Bachert C, Zhang N, van Zele T and Gevaert P: Chronic rhinosinusitis: From one disease to different phenotypes. Pediatr Allergy Immunol. 23 Suppl 22:S2–S4. 2012. View Article : Google Scholar

2 

Bachert C, Mannent L, Naclerio RM, Mullol J, Ferguson BJ, Gevaert P, Hellings P, Jiao L, Wang L, Evans RR, et al: Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: A randomized clinical trial. JAMA. 315:469–479. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Neubauer PD, Schwam ZG and Manes RP: Comparison of intranasal fluticasone spray, budesonide atomizer, and budesonide respules in patients with chronic rhinosinusitis with polyposis after endoscopic sinus surgery. Int Forum Allergy Rhinol. 6:233–237. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Johansson L, Akerlund A, Holmberg K, Melén I and Bende M: Prevalence of nasal polyps in adults: The Skövde population-based study. Ann Otol Rhinol Laryngol. 112:625–629. 2003. View Article : Google Scholar : PubMed/NCBI

5 

We J, Lee WH, Tan KL, Wee JH, Rhee CS, Lee CH, Ahn S, Lee JH and Kim JW: Prevalence of nasal polyps and its risk factors: Korean national health and nutrition examination survey 2009–2011. Am J Rhinol Allergy. 29:e24–e28. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Feng S, He Q, Fan Y, Mi J, Guo L, Hong H and Li H: Nasal endoscopic findings and nasal symptoms in patients with asthma: A clinical study from a rhinological perspective. Allergol Immunopathol (Madr). 43:42–47. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Fetta M, Tsilis NS, Segas JV, Nikolopoulos TP and Vlastarakos PV: Functional endoscopic sinus surgery improves the quality of life in children suffering from chronic rhinosinusitis with nasal polyps. Int J Pediatr Otorhinolaryngol. 100:145–148. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Weber SAT, Iyomasa RM, Correa CC, Florentino WNM and Ferrari GF: Nasal polyposis in cystic fibrosis: Follow-up of children and adolescents for a 3-year period. Braz J Otorhinolaryngol. 83:677–682. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Veloso-Teles R and Cerejeira R: Endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps: Clinical outcome and predictive factors of recurrence. Am J Rhinol Allergy. 31:56–62. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Park IH, Um JY, Hong SM, Cho JS, Lee SH, Lee SH and Lee HM: Metformin reduces TGF-β1-induced extracellular matrix production in nasal polyp-derived fibroblasts. Otolaryngol Head Neck Surg. 150:148–153. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Piersma B, Bank RA and Boersema M: Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge. Front Med (Lausanne). 2:592015.PubMed/NCBI

12 

Castellone MD and Laukkanen MO: TGF-beta1, WNT, and SHH signaling in tumor progression and in fibrotic diseases. Front Biosci (Schol Ed). 9:31–45. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Poniatowski LA, Wojdasiewicz P, Gasik R and Szukiewicz D: Transforming growth factor Beta family: Insight into the role of growth factors in regulation of fracture healing biology and potential clinical applications. Mediators Inflamm. 2015:1378232015. View Article : Google Scholar : PubMed/NCBI

14 

Vadon-Le Goff S, Hulmes DJ and Moali C: BMP-1/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling. Matrix Biol. 44–46:14–23. 2015. View Article : Google Scholar

15 

Richter K, Konzack A, Pihlajaniemi T, Heljasvaara R and Kietzmann T: Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences. Redox Biol. 6:344–352. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Lafyatis R: Transforming growth factor β-at the centre of systemic sclerosis. Nat Rev Rheumatol. 10:706–719. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Huang Y, Liu J, Fan L, Wang F, Yu H, Wei W and Sun G: miR-663 overexpression induced by endoplasmic reticulum stress modulates hepatocellular carcinoma cell apoptosis via transforming growth factor beta 1. Onco Targets Ther. 9:1623–1633. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Wang Z, Zhang H, Zhang P, Dong W and He L: MicroRNA-663 suppresses cell invasion and migration by targeting transforming growth factor beta 1 in papillary thyroid carcinoma. Tumour Biol. 37:7633–7644. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Fokkens W, Lund V and Mullol J: European Position Paper on Rhinosinusitis and Nasal Polyps Group: EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists. Rhinology. 45:97–101. 2007.PubMed/NCBI

20 

Qin JJ, Lu ZY, Jiao ZP, Zhu XJ, Wang YX and Tang H: Modified TRIzol method for RNA and DNA co-extraction from blood. Fa Yi Xue Za Zhi. 29:209–211. 2013.(In Chinese). PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Hulse KE, Stevens WW, Tan BK and Schleimer RP: Pathogenesis of nasal polyposis. Clin Exp Allergy. 45:328–346. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Bernstein JM, Gorfien J and Noble B: Role of allergy in nasal polyposis: A review. Otolaryngol Head Neck Surg. 113:724–732. 1995. View Article : Google Scholar : PubMed/NCBI

24 

Calus L, Devuyst L, Van Zele T, De Ruyck N, Derycke L, Bachert C and Gevaert P: The response to nasal allergen provocation with grass pollen is reduced in patients with chronic rhinosinusitis with nasal polyposis and grass sensitization. Clin Exp Allergy. 46:555–563. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Becker S, Rasp J, Eder K, Berghaus A, Kramer MF and Gröger M: Non-allergic rhinitis with eosinophilia syndrome is not associated with local production of specific IgE in nasal mucosa. Eur Arch Otorhinolaryngol. 273:1469–1475. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Fokkens W, Lund V and Mullol J: European Position Paper on Rhinosinusitis and Nasal Polyps group: European position paper on rhinosinusitis and nasal polyps 2007. Rhinol Suppl. 20:1–136. 2007.PubMed/NCBI

27 

Fundová P, Funda DP, Kovar D, Holy R, Navara M and Tlaskalová-Hogenová H: Increased expression of chemokine receptors CCR1 and CCR3 in nasal polyps: Molecular basis for recruitment of the granulocyte infiltrate. Folia Microbiol (Praha). 58:219–224. 2013. View Article : Google Scholar : PubMed/NCBI

28 

De Corso E, Baroni S, Romitelli F, Luca L, Di Nardo W, Passali GC and Paludetti G: Nasal lavage CCL24 levels correlate with eosinophils trafficking and symptoms in chronic sino-nasal eosinophilic inflammation. Rhinology. 49:174–179. 2011.PubMed/NCBI

29 

Pawankar R and Nonaka M: Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps. Curr Allergy Asthma Rep. 7:202–208. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Pawliczak R, Lewandowska-Polak A and Kowalski ML: Pathogenesis of nasal polyps: An update. Curr Allergy Asthma Rep. 5:463–471. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Janda K, Krzanowski M, Dumnicka P, Kusnierz-Cabala B, Krasniak A and Sulowicz W: Transforming growth factor beta 1 as a risk factor for cardiovascular diseases in end-stage renal disease patients treated with peritoneal dialysis. Clin Lab. 60:1163–1168. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Jin X, Ren S, Macarak E and Rosenbloom J: Pathobiological mechanisms of peritoneal adhesions: The mesenchymal transition of rat peritoneal mesothelial cells induced by TGF-β1 and IL-6 requires activation of Erk1/2 and Smad2 linker region phosphorylation. Matrix Biol. 51:55–64. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Xiao K, Jiao L, Cao S, Song Z, Hu C and Han X: Whey protein concentrate enhances intestinal integrity and influences transforming growth factor-β1 and mitogen-activated protein kinase signalling pathways in piglets after lipopolysaccharide challenge. Br J Nutr. 115:984–993. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Cicha I, Yilmaz A, Klein M, Raithel D, Brigstock DR, Daniel WG, Goppelt-Struebe M and Garlichs CD: Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro. Arterioscler Thromb Vasc Biol. 25:1008–1013. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Chen S, Liu J, Yang M, Lai W, Ye L, Chen J, Hou X, Ding H, Zhang W, Wu Y, et al: Fn14, a downstream target of the TGF-β signaling pathway, regulates fibroblast activation. PLoS One. 10:e01438022015. View Article : Google Scholar : PubMed/NCBI

36 

Kanaan RA, Aldwaik M and Al-Hanbali OA: The role of connective tissue growth factor in skeletal growth and development. Med Sci Monit. 12:RA277–RA281. 2006.PubMed/NCBI

37 

Aström P, Pirilä E, Lithovius R, Heikkola H, Korpi JT, Hernández M, Sorsa T and Salo T: Matrix metalloproteinase-8 regulates transforming growth factor-β1 levels in mouse tongue wounds and fibroblasts in vitro. Exp Cell Res. 328:217–227. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Park SK, Jin YD, Park YK, Yeon SH, Xu J, Han RN, Rha KS and Kim YM: IL-25-induced activation of nasal fibroblast and its association with the remodeling of chronic rhinosinusitis with nasal polyposis. PLoS One. 12:e01818062017. View Article : Google Scholar : PubMed/NCBI

39 

Shin JM, Park JH, Kang B, Lee SA, Park IH and Lee HM: Effect of doxycycline on transforming growth factor-beta-1-induced matrix metalloproteinase 2 expression, migration, and collagen contraction in nasal polyp-derived fibroblasts. Am J Rhinol Allergy. 30:385–390. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Xiao Z, Zhang J, Peng X, Dong Y, Jia L, Li H and Du J: The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation. Int J Biochem Cell Biol. 55:65–71. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Shi Y, Ye K, Wu H, Sun Y, Shi H and Huo K: Human SMAD4 is phosphorylated at Thr9 and Ser138 by interacting with NLK. Mol Cell Biochem. 333:293–298. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Lazzarini R, Sorgentoni G, Caffarini M, Sayeed MA, Olivieri F, Di Primio R and Orciani M: New miRNAs network in human mesenchymal stem cells derived from skin and amniotic fluid. Int J Immunopathol Pharmacol. 29:523–528. 2016. View Article : Google Scholar : PubMed/NCBI

43 

He X, Liu Z, Peng Y and Yu C: MicroRNA-181c inhibits glioblastoma cell invasion, migration and mesenchymal transition by targeting TGF-β pathway. Biochem Biophys Res Commun. 469:1041–1048. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Stolzenburg LR, Wachtel S, Dang H and Harris A: microRNA-1343 attenuates pathways of fibrosis by targeting the TGF-β receptors. Biochem J. 473:245–256. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Shin JM, Park JH, Park IH and Lee HM: Pirfenidone inhibits transforming growth factor β1-induced extracellular matrix production in nasal polyp-derived fibroblasts. Am J Rhinol Allergy. 29:408–413. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Yamin M, Holbrook EH, Gray ST, Busaba NY, Lovett B and Hamilos DL: Profibrotic transforming growth factor beta 1 and activin A are increased in nasal polyp tissue and induced in nasal polyp epithelium by cigarette smoke and Toll-like receptor 3 ligation. Int Forum Allergy Rhinol. 5:573–582. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yu H, Ju J, Liu J and Li D: Aberrant expression of miR-663 and transforming growth factor-β1 in nasal polyposis in children. Exp Ther Med 15: 4550-4556, 2018.
APA
Yu, H., Ju, J., Liu, J., & Li, D. (2018). Aberrant expression of miR-663 and transforming growth factor-β1 in nasal polyposis in children. Experimental and Therapeutic Medicine, 15, 4550-4556. https://doi.org/10.3892/etm.2018.5927
MLA
Yu, H., Ju, J., Liu, J., Li, D."Aberrant expression of miR-663 and transforming growth factor-β1 in nasal polyposis in children". Experimental and Therapeutic Medicine 15.5 (2018): 4550-4556.
Chicago
Yu, H., Ju, J., Liu, J., Li, D."Aberrant expression of miR-663 and transforming growth factor-β1 in nasal polyposis in children". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4550-4556. https://doi.org/10.3892/etm.2018.5927
Copy and paste a formatted citation
x
Spandidos Publications style
Yu H, Ju J, Liu J and Li D: Aberrant expression of miR-663 and transforming growth factor-β1 in nasal polyposis in children. Exp Ther Med 15: 4550-4556, 2018.
APA
Yu, H., Ju, J., Liu, J., & Li, D. (2018). Aberrant expression of miR-663 and transforming growth factor-β1 in nasal polyposis in children. Experimental and Therapeutic Medicine, 15, 4550-4556. https://doi.org/10.3892/etm.2018.5927
MLA
Yu, H., Ju, J., Liu, J., Li, D."Aberrant expression of miR-663 and transforming growth factor-β1 in nasal polyposis in children". Experimental and Therapeutic Medicine 15.5 (2018): 4550-4556.
Chicago
Yu, H., Ju, J., Liu, J., Li, D."Aberrant expression of miR-663 and transforming growth factor-β1 in nasal polyposis in children". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4550-4556. https://doi.org/10.3892/etm.2018.5927
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team