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Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats

  • Authors:
    • Rong-Sheng Cui
    • Kai Wang
    • Zhong-Li Wang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesia, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China
    Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4127-4130
    |
    Published online on: March 20, 2018
       https://doi.org/10.3892/etm.2018.5976
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Abstract

The present study was designed to investigate the effects of sevoflurane inhalation anesthesia on the cognitive function of rats and to investigate the molecular mechanisms mediating this effect. A total of 100 healthy male Sprague‑Dawley rats were divided into four groups: i) Control (air inhalation), ii) low‑dose (1.5% sevoflurane inhalation for 2 h), iii) high‑dose (3% sevoflurane inhalation for 2 h), and iv) nimodipine group (3% sevoflurane inhalation for 2 h + nimodipine). Sevoflurane inhalation anesthesia resulted in cognitive dysfunction in a dose-dependent manner. Sevoflurane also upregulated the expression of tumour necrosis factor-α (TNF-α), interleukin (IL) -6, -8, and Caspase-3 in the hippocampus. The intervention with nimodipine partially recovered the cognitive function and the abnormal expression of TNF-α, IL-6, IL-8, and Caspase-3 induced by sevoflurane. The results showed that the cognitive dysfunction caused by sevoflurane inhalation in rats may be related to the activation of inflammatory and apoptotic pathways. The neuroprotective effect of nimodipine suggests that abnormal calcium transport is partially responsible for the sevoflurane toxicity.
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Copy and paste a formatted citation
Spandidos Publications style
Cui R, Wang K and Wang Z: Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats. Exp Ther Med 15: 4127-4130, 2018.
APA
Cui, R., Wang, K., & Wang, Z. (2018). Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats. Experimental and Therapeutic Medicine, 15, 4127-4130. https://doi.org/10.3892/etm.2018.5976
MLA
Cui, R., Wang, K., Wang, Z."Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats". Experimental and Therapeutic Medicine 15.5 (2018): 4127-4130.
Chicago
Cui, R., Wang, K., Wang, Z."Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4127-4130. https://doi.org/10.3892/etm.2018.5976
Copy and paste a formatted citation
x
Spandidos Publications style
Cui R, Wang K and Wang Z: Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats. Exp Ther Med 15: 4127-4130, 2018.
APA
Cui, R., Wang, K., & Wang, Z. (2018). Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats. Experimental and Therapeutic Medicine, 15, 4127-4130. https://doi.org/10.3892/etm.2018.5976
MLA
Cui, R., Wang, K., Wang, Z."Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats". Experimental and Therapeutic Medicine 15.5 (2018): 4127-4130.
Chicago
Cui, R., Wang, K., Wang, Z."Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4127-4130. https://doi.org/10.3892/etm.2018.5976
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