Observation of curative effects of Ex-PRESS and AGV implantation in the treatment of refractory glaucoma

Bo,Wen; Dai,Dongmei; Sun,Fengxia

doi:10.3892/etm.2018.5977

May-2018 Volume 15 Issue 5

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May-2018 Volume 15 Issue 5

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Article Open Access

Observation of curative effects of Ex-PRESS and AGV implantation in the treatment of refractory glaucoma

Authors:
- Wen Bo
- Dongmei Dai
- Fengxia Sun
View Affiliations / Copyright

Affiliations: Department of Ophthalmology, Zaozhuang Ophthalmologic Hospital, Maternity and Child Health Care of Zaozhuang, Zaozhuang, Shandong 277100, P.R. China

Copyright: © Bo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 4419-4425
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Published online on: March 20, 2018

https://doi.org/10.3892/etm.2018.5977
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Abstract

The curative effects of Ex-PRESS implantation and Ahmed glaucoma valve (AGV) implantation in the treatment of refractory glaucoma were compared. A total of 68 patients (76 eyes) with refractory glaucoma treated were randomly divided into Ex-PRESS group and AGV group. Results showed that the intraocular pressure IOP in both Ex-PRESS group and AGV group after operation was significantly decreased compared with that before operation (P<0.001). At 3, 6 and 9 months after operation, IOP in Ex-PRESS group was significantly lower than that in AGV group (P<0.05). At the end of follow-up, BCVA of patients in both groups after operation was slightly decreased compared with that before operation (P>0.05). There was no statistically significant difference in BCVA between the two groups of patients (P>0.05). Moreover, the corneal endothelial cell counts of patients in both groups after operation were obviously decreased compared with those before operation (P<0.05). The number of anti-glaucoma drugs applied was decreased from 3.53±0.86 to 0.55±0.60 in Ex-PRESS, and from 3.24±0.88 to 0.89±0.73 in AGV group. At the end of follow-up, the number of anti-glaucoma drugs applied in Ex-PRESS group was smaller than that in AGV group (P<0.05). There was no statistically significant difference in success rate of operation between the two groups at the end of follow-up (log-rank test; P>0.05). Finally, the incidence rates of postoperative complications and surgical intervention rates had no statistically significant differences between the two groups. Ex-PRESS implantation is a safe and effective treatment for refractory glaucoma, characterized by simple operation, small trauma and less pain, which has an equivalent curative effect to AGV implantation; but its control effect on IOP after operation is superior to that of AGV, and the number of anti-glaucoma drugs applied after operation is small.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Observation of curative effects of Ex-PRESS and AGV implantation in the treatment of refractory glaucoma

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