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Curative effects of GM1 in the treatment of severe ischemic brain injury and its effects on serum TNF-α and NDS

  • Authors:
    • Fang Liu
    • Xiaoling Sun
    • Yunxia Zhang
    • Guoliang Zhao
    • Yancang Liu
    • Yiwu Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery Medicine, Yantai Yuhuangding Hospital of Shandong, Yantai, Shandong 264000, P.R. China, Department of Emergency Medicine, The First People's Hospital of Jining, Jining, Shandong 272011, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4851-4855
    |
    Published online on: March 27, 2018
       https://doi.org/10.3892/etm.2018.5995
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Abstract

The curative effects of monosialotetrahexosyl ganglioside (GM1) in the treatment of severe ischemic brain injury and its effects on tumor necrosis factor-α (TNF-α) and neuropathy disability score (NDS). Sixty patients with severe ischemic brain injury admitted to The First People's Hospital of Jining (Jining, China) from June 2014 to March 2016 were selected. They were randomly divided into the control group (n=30) and the experimental group (n=30). The patients in the control group were treated with routine therapy while those in the experimental group were treated with GM1. The level of TNF-α in the serum was measured by the enzyme‑linked immunosorbent assay. The NDS was used to grade the two groups; Pearson's correlation coefficient was applied to analyze the correlation between the content of TNF-α and NDS; the content of superoxide dismutase (SOD) was detected using xanthine oxidase assay, and the content of malondialdehyde (MDA) was detected by thiobarbituric acid method. The clinical recovery time of two groups of patients was recorded. At 14 days after GM1 treatment, the serum TNF-α content and the NDS in the experimental group were significantly lower than those in the control group (P<0.05). The content of TNF-α in the patients was positively correlated with the NDS. After treatment, the serum MDA content of patients in the experimental group was lower, while the SOD content was significantly higher than that in the control group (P<0.05). After GM1 treatment, hemodynamic parameters of patients in the experimental group were significantly improved compared with those in the control group. The total effective rate of GM1 treatment in the experimental group was higher than that in the control group (P<0.05). GM1 has a good clinical significance in the treatment of patients with severe ischemic brain injury and is worthy of clinical promotion and application.
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1 

Broughton BRS, Reutens DC and Sobey CG: Apoptotic mechanisms after cerebral ischemia. Stroke. 40:e331–e339. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Kahlert P, Knipp SC, Schlamann M, Thielmann M, Al-Rashid F, Weber M, Johansson U, Wendt D, Jakob HG, Forsting M, et al: Silent and apparent cerebral ischemia after percutaneous transfemoral aortic valve implantation: A diffusion-weighted magnetic resonance imaging study. Circulation. 121:870–878. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Beck H and Plate KH: Angiogenesis after cerebral ischemia. Acta Neuropathol. 117:481–496. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Hossmann KA: Treatment of experimental cerebral ischemia. J Cereb Blood Flow Metab. 2:275–297. 1982. View Article : Google Scholar : PubMed/NCBI

5 

Maher J and Hachinski V: Hypothermia as a potential treatment for cerebral ischemia. Cerebrovasc Brain Metab Rev. 5:277–300. 1993.PubMed/NCBI

6 

Ginsberg MD: Current status of neuroprotection for cerebral ischemia: Synoptic overview. Stroke. 40 Suppl 3:S111–S114. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Ledeen RW and Wu G: The multi-tasked life of GM1 ganglioside, a true factotum of nature. Trends Biochem Sci. 40:407–418. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Wang Q, Song YH, Tang Z, Wang ZP, Xu Q and Bao N: Effects of ganglioside GM1 and neural growth factor on neural stem cell proliferation and differentiation. Genet Mol Res. Aug 5–2016.(Epub ahead of print). doi: 10.4238/gmr.15038376.

9 

Gao M, Ding H, Zhong G, Lu J, Wang H, Li Q and Wang Z: The effects of transrectal radiofrequency hyperthermia on patients with chronic prostatitis and the changes of MDA, NO, SOD, and Zn levels in pretreatment and posttreatment. Urology. 79:391–396. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Daousi C, Benbow SJ, Woodward A and MacFarlane IA: The natural history of chronic painful peripheral neuropathy in a community diabetes population. Diabet Med. 23:1021–1024. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Wu X: Summary of the Fourth National Cerebrovascular Disease Conference. Stroke Nerv Dis:. 4:105–109. 1997.

12 

Niizuma K, Yoshioka H, Chen H, Kim GS, Jung JE, Katsu M, Okami N and Chan PH: Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. Mol Basis Dis. 1802:92–99. 2010. View Article : Google Scholar

13 

Wang JY, Xia Q, Chu KT, Pan J, Sun LN, Zeng B, Zhu YJ, Wang Q, Wang K and Luo BY: Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: A widely used inhibitor of autophagy. J Neuropathol Exp Neurol. 70:314–322. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Zhang F and Chen J: Leptin protects hippocampal CA1 neurons against ischemic injury. J Neurochem. 107:578–587. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Lee JJ, Li L, Jung H and Zuo Z: Postconditioning with isoflurane reduced ischemia-induced brain injury in rats. Anesthesiology. 108:1055–1062. 2008. View Article : Google Scholar : PubMed/NCBI

16 

del Zoppo GJ and Zoppo G: Inflammation and the neurovascular unit in the setting of focal cerebral ischemia. Neuroscience. 158:972–982. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Wei L, Fraser JL, Lu ZY, Hu X and Yu SP: Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and neurogenesis after cerebral ischemia in rats. Neurobiol Dis. 46:635–645. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Niatsetskaya ZV, Sosunov SA, Matsiukevich D, Utkina-Sosunova IV, Ratner VI, Starkov AA and Ten VS: The oxygen free radicals originating from mitochondrial complex I contribute to oxidative brain injury following hypoxia-ischemia in neonatal mice. J Neurosci. 32:3235–3244. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Kumar A, Mittal R, Khanna HD and Basu S: Free radical injury and blood-brain barrier permeability in hypoxic-ischemic encephalopathy. Pediatrics. 122:e722–e727. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Candelario-Jalil E, Yang Y and Rosenberg GA: Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience. 158:983–994. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Iadecola C and Alexander M: Cerebral ischemia and inflammation. Curr Opin Neurol. 14:89–94. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Günther C, Buchen B, He GW, Hornef M, Torow N, Neumann H, Wittkopf N, Martini E, Basic M, Bleich A, et al: Caspase-8 controls the gut response to microbial challenges by TNF-α-dependent and independent pathways. Gut. 64:601–610. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu F, Sun X, Zhang Y, Zhao G, Liu Y and Zhang Y: Curative effects of GM1 in the treatment of severe ischemic brain injury and its effects on serum TNF-α and NDS. Exp Ther Med 15: 4851-4855, 2018.
APA
Liu, F., Sun, X., Zhang, Y., Zhao, G., Liu, Y., & Zhang, Y. (2018). Curative effects of GM1 in the treatment of severe ischemic brain injury and its effects on serum TNF-α and NDS. Experimental and Therapeutic Medicine, 15, 4851-4855. https://doi.org/10.3892/etm.2018.5995
MLA
Liu, F., Sun, X., Zhang, Y., Zhao, G., Liu, Y., Zhang, Y."Curative effects of GM1 in the treatment of severe ischemic brain injury and its effects on serum TNF-α and NDS". Experimental and Therapeutic Medicine 15.6 (2018): 4851-4855.
Chicago
Liu, F., Sun, X., Zhang, Y., Zhao, G., Liu, Y., Zhang, Y."Curative effects of GM1 in the treatment of severe ischemic brain injury and its effects on serum TNF-α and NDS". Experimental and Therapeutic Medicine 15, no. 6 (2018): 4851-4855. https://doi.org/10.3892/etm.2018.5995
Copy and paste a formatted citation
x
Spandidos Publications style
Liu F, Sun X, Zhang Y, Zhao G, Liu Y and Zhang Y: Curative effects of GM1 in the treatment of severe ischemic brain injury and its effects on serum TNF-α and NDS. Exp Ther Med 15: 4851-4855, 2018.
APA
Liu, F., Sun, X., Zhang, Y., Zhao, G., Liu, Y., & Zhang, Y. (2018). Curative effects of GM1 in the treatment of severe ischemic brain injury and its effects on serum TNF-α and NDS. Experimental and Therapeutic Medicine, 15, 4851-4855. https://doi.org/10.3892/etm.2018.5995
MLA
Liu, F., Sun, X., Zhang, Y., Zhao, G., Liu, Y., Zhang, Y."Curative effects of GM1 in the treatment of severe ischemic brain injury and its effects on serum TNF-α and NDS". Experimental and Therapeutic Medicine 15.6 (2018): 4851-4855.
Chicago
Liu, F., Sun, X., Zhang, Y., Zhao, G., Liu, Y., Zhang, Y."Curative effects of GM1 in the treatment of severe ischemic brain injury and its effects on serum TNF-α and NDS". Experimental and Therapeutic Medicine 15, no. 6 (2018): 4851-4855. https://doi.org/10.3892/etm.2018.5995
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