Observation of corneal transplantation in peripheral corneal disease postoperatively

Zhang,Yibing; Hu,Yuan; Li,Xiaodong; Shi,Xiaoru; Xu,Feihong; Jia,Hui

doi:10.3892/etm.2018.6100

June-2018 Volume 15 Issue 6

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June-2018 Volume 15 Issue 6

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Article

Observation of corneal transplantation in peripheral corneal disease postoperatively

Authors:
- Yibing Zhang
- Yuan Hu
- Xiaodong Li
- Xiaoru Shi
- Feihong Xu
- Hui Jia
View Affiliations / Copyright

Affiliations: Department of Ophthalmology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Ophthalmology, Baicheng Central Hospital, Baicheng, Jilin 137000, P.R. China
Pages: 5384-5388
|
Published online on: April 25, 2018

https://doi.org/10.3892/etm.2018.6100
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Abstract

The aim of the present study was to investigate the role of the limbal stem cells in corneal epithelial homeostasis in patients with peripheral corneal disease who received corneal transplantation surgery. This retrospective study enrolled 85 patients (85 eyes) with peripheral corneal lesion who underwent corneal transplantation at Department of Ophthalmology in First Hospital of Jilin University, Jilin, China. All patients during each follow‑up period were examined for best corrected visual acuity, corneal reconstruction (assessed by slit‑lamp biomicroscopy), anterior segment optical coherence tomography, and confocal microscopy. Patients were followed up for 3.5±2.4 years. All patients had improved postoperative best corrected visual acuity. Neither vascularization nor conjunctivalization of the graft occurred. Scanning of the graft was covered by normal corneal epithelium as confirmed on the laser scanning in vivo confocal microscopy. No evidence of normal limbal was detected in any of the operation eyes. The limbal stem cells may not play a critical role during normal corneal epithelial turnover in patients with peripheral corneal disease following corneal transplantation surgery.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Observation of corneal transplantation in peripheral corneal disease postoperatively

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