Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Spontaneous remission of obstructive jaundice in rats: Selection of experimental models

  • Authors:
    • Yunfu Lv
    • Jie Yue
    • Xiaoguang Gong
    • Xiaoyu Han
    • Hongfei Wu
    • Jie Deng
    • Yejuan Li
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Hainan Provincial People's Hospital, Haikou, Hainan 570311, P.R. China, Department of Reproductive Medicine, Maternal and Child Health Care Hospital, Haikou, Hainan 571000, P.R. China
    Copyright: © Lv et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5295-5301
    |
    Published online on: May 2, 2018
       https://doi.org/10.3892/etm.2018.6119
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to evaluate the prevalence and causes of spontaneous remission of obstructive jaundice in rats. Healthy male and female Wistar rats (180‑220 g) were randomly assigned to receive common bile duct ligation (CBDL) and transection (group A), CBDL only (group B), or CBD dissection without ligation or transection (control group C; n=36 in each group). There was a difference in eye and skin jaundice prevalence between groups A and B from 14 days after surgery. The level of total bilirubin (TB) did not continue to increase in group A and began to decrease in the majority of rats in group B (P<0.05 vs. group B). At day 21 after surgery, the TB level returned to normal in group B and no significant difference was observed compared with group C. At day 21 after surgery, significant dilatation of bile ducts above the ligature was observed in group A following cholangiography with 38% meglumine diatrizoate and this contrast agent did not spread to other sites. Slight dilatation of the proximal bile ducts was observed in group B and the contrast agent entered the intestinal lumen through the omental ducts adhering to the porta hepatis. After 14 days of surgery, there were 36 rats in group A and B, and 17 rats exhibited spontaneous regression of jaundice. Overall, 47.2% (17/36) of rats experienced spontaneous remission of obstructive jaundice, 82.4% (14/17) of which underwent ligation only. The spontaneous remission of jaundice may have been caused by shunting through very small bile ducts or omental ducts adhering to the porta hepatis. If a model of biliary obstruction is to be established in future research, a model of CBDL and transection is preferable. In this case, jaundice reduction surgery should be performed 14 days after establishment of the model.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

View References

1 

Bulte JW, Schmieder AH, Keupp J, Caruthers SD, Wickline SA and Lanza GM: MR cholangiography demonstrates unsuspected rapid biliary clearance of nanoparticles in rodents: Implications for clinical translation. Nanomedicine. 10:1385–1388. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Ferreira MA, Santos JS, Dutra RA, Salgado W Jr, Kemp R, Domiciano C, Ramalho LN, Sankarankutty AK and Castro-e-Silva Od: Bilioduodenal anastomosis in rats with extra-hepatic biliary obstruction is followed by lesions ischemia and reperfusion-induced. Acta Cir Bras. 23 Suppl 1:S47–S52. 2008. View Article : Google Scholar

3 

Kemp R, de Araújo WM, de Castro AA, Ardengh JC, Neder L and dos Santos JS: Influence of biliary drainage on the repair of hepatic lesions in biliary fibrosis. J Surg Res. 169:e127–e136. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Wang ZK, Xiao JG, Huang XF, Gong YC and Li W: Effect of biliary drainage on inducible nitric oxide synthase, CD14 and TGR5 expression in obstructive jaundice rats. World J Gastroenterol. 19:2319–2330. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Li JY, Zhu X and Fu ZM: Experimental study of postoperative obstructive jaundice and postoperative care. Jiangxi Yixueyuan Xuebao. 31:73–76. 1991.(In Chinese).

6 

Saiki S, Chijiiwa K, Komura M, Yamaguchi K, Kuroki S and Tanaka M: Preoperative internal biliary drainage is inferior to external biliary drainage in liver regeneration and function after hepatecctomy in obstruction jaundice rats. Ann Surg. 230:655–662. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Su X, Luo KF, Wu L, Wu LL and Li Wen: The correlation study of the plasma diamine oxidase activities and the intestinal barrier function in rats with obstructive jaundice after internal and external biliary drainages. Xian Dai Sheng Wu Yi Xue Jin Zhan. 17:3216–3219. 2014.(In Chinese).

8 

Gong YH and Li W: The different effects of internal and external biliary drainages on the blood levels of endotoxin, interleukin-2 and interleukin-6 in rats with obstructive jaundice. Weichangbingxue He Ganbingxue Zazhi. 4:329–331. 2008.(In Chinese).

9 

Zeng Y, Zhang Y, Zheng S and Dong J: Establishment of model of selective external biliary drainage in rats with obstructive jaundice. Zhonghua Xiao Hua Wai Ke Za Zhi. 6:209–212. 2007.(In Chinese).

10 

Zhang SH, Liao CX, Zhang CX, Deng H, Zhu H, Lei L and Yao C: Establishment of a mouse model of biliary obstruction and its dynamic observations. Nan Fang Yi Ke Da Xue Xue Bao. 28:1579–1581. 2008.(In Chinese). PubMed/NCBI

11 

Wu W, Yang Y and Huang Q: Bilirubin metabolism after obstructive jaundice in rats. Zhonghua Gan Dan Wai Ke Za Zhi. 5:288–291. 2001.(In Chinese).

12 

Ni Y, Marchal G, Lukito G, Yu J, Mühler A and Baert AL: MR imaging evaluation of liver enhancement by Gd-EOB-DTPA in selective and total bile duct obstruction in rats: Correlation with serologic, microcholangiographic, and histologic findings. Radiology. 190:753–758. 1994. View Article : Google Scholar : PubMed/NCBI

13 

Kountouras J, Scheuer PJ and Billing BH: Effect of prolonged bile duct obstruction in the rat on hepatic transport of bilirubin. Clin Sci (Lond). 68:341–347. 1985. View Article : Google Scholar : PubMed/NCBI

14 

Huang Q, Liu C, Zhu C, Xie F and Hu S: Postoperative anastomotic bile duct stricture is affected by the experience of surgeons and the choice of surgical procedures but not the timing of repair after obstructive bile duct injury. Int J Clin Exp Pathol. 7:6635–6643. 2014.PubMed/NCBI

15 

McIntyre N and Rosalki S: Biochemical investigations in the management of liver diseaseHepatobiliary Diseases. Springer; Berlin: pp. 39–71. 1992, View Article : Google Scholar

16 

Nehéz L and Andersson R: Compromise of immune function in obstructive jaundice. Eur J Surg. 168:315–328. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Scopa CD, Koureleas S, Tsamandas AC, Spiliopoulou I, Alexandrides T, Filos KS and Vagianos CE: Beneficial effects of growth hormone and insulin-like growth factor I on intestinal bacterial translocation, endotoxemia, and apoptosis in experimentally jaundiced rats. J Am Coll Surg. 190:423–431. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Sinenchenko GI, Kabanov Mlu and Tikhonchuk SV: Perspectives of using ozonized solutions in complex treatment of patients with mechanical jaundice. Vestn Khir Im I I Grek. 163:91–94. 2003.(In Russian).

19 

Shibayama Y: Endotoxaemia and hepatic injury in obstructive jaundice. J Pathol. 159:335–339. 1989. View Article : Google Scholar : PubMed/NCBI

20 

Huang Z and Zou S: Extrahepatic biliary ductBiliary Surgery. Beijing: People's Medical Publishing House; pp. 23–26. 2010, (In Chinese).

21 

Lv Y, Han X, Gong X, Wu H, Liu N, Hu Y, Deng J, Li Y and Li Q: Etiological classification of bile duct dilatation and proportion of each cause in 1430 patients. Int J New Technol Res. 1:51–54. 2015.

22 

Kordzaia D and Jangavadze M: Unknown bile ductuli accompanying hepatic vein tributaries (experimental study). Georgian Med News. 234:121–129. 2014.

23 

Lv Y and Dang J: Diagnostics and therapeutics of intra-extrahepatic cholangiectasis (Chinese edition). Science Press. 1:319–321. 2014.

24 

Tag CG, Weiskirchen S, Hittatiya K, Tacke F, Tolba RH and Weiskirchen R: Induction of experimental obstructive cholestasis in mice. Lab Anim. 49 1 Suppl:70–80. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lv Y, Yue J, Gong X, Han X, Wu H, Deng J and Li Y: Spontaneous remission of obstructive jaundice in rats: Selection of experimental models. Exp Ther Med 15: 5295-5301, 2018.
APA
Lv, Y., Yue, J., Gong, X., Han, X., Wu, H., Deng, J., & Li, Y. (2018). Spontaneous remission of obstructive jaundice in rats: Selection of experimental models. Experimental and Therapeutic Medicine, 15, 5295-5301. https://doi.org/10.3892/etm.2018.6119
MLA
Lv, Y., Yue, J., Gong, X., Han, X., Wu, H., Deng, J., Li, Y."Spontaneous remission of obstructive jaundice in rats: Selection of experimental models". Experimental and Therapeutic Medicine 15.6 (2018): 5295-5301.
Chicago
Lv, Y., Yue, J., Gong, X., Han, X., Wu, H., Deng, J., Li, Y."Spontaneous remission of obstructive jaundice in rats: Selection of experimental models". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5295-5301. https://doi.org/10.3892/etm.2018.6119
Copy and paste a formatted citation
x
Spandidos Publications style
Lv Y, Yue J, Gong X, Han X, Wu H, Deng J and Li Y: Spontaneous remission of obstructive jaundice in rats: Selection of experimental models. Exp Ther Med 15: 5295-5301, 2018.
APA
Lv, Y., Yue, J., Gong, X., Han, X., Wu, H., Deng, J., & Li, Y. (2018). Spontaneous remission of obstructive jaundice in rats: Selection of experimental models. Experimental and Therapeutic Medicine, 15, 5295-5301. https://doi.org/10.3892/etm.2018.6119
MLA
Lv, Y., Yue, J., Gong, X., Han, X., Wu, H., Deng, J., Li, Y."Spontaneous remission of obstructive jaundice in rats: Selection of experimental models". Experimental and Therapeutic Medicine 15.6 (2018): 5295-5301.
Chicago
Lv, Y., Yue, J., Gong, X., Han, X., Wu, H., Deng, J., Li, Y."Spontaneous remission of obstructive jaundice in rats: Selection of experimental models". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5295-5301. https://doi.org/10.3892/etm.2018.6119
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team