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Hematopoietically expressed homeobox gene is associated with type 2 diabetes in KK Cg‑Ay/J mice and a Taiwanese Han Chinese population

  • Authors:
    • Chi‑Cheng Lu
    • Yng‑Tay Chen
    • Shih‑Yin Chen
    • Yuan‑Man Hsu
    • Chyi‑Chyang Lin
    • Je‑Wei Tsao
    • Yu‑Ning Juan
    • Jai‑Sing Yang
    • Fuu‑Jen Tsai
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Buddhist Tzu Chi General Hospital, Hualien 97002, Taiwan, R.O.C., Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan, R.O.C., Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan, R.O.C., School of Pharmacy, China Medical University, Taichung 40402, Taiwan, R.O.C., Human Genetics Center, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan, R.O.C.
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 185-191
    |
    Published online on: May 10, 2018
       https://doi.org/10.3892/etm.2018.6152
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Abstract

Diabetes mellitus (DM) is a chronic disease. The KK Cg‑Ay/J (KK‑Ay) mouse is an animal model to study type 2 diabetes mellitus (T2D) disease. The present study assessed the expression of hematopoietically expressed homeobox (HHEX) protein in liver tissues of different age groups of mice (6, 16 and 42 weeks) by immunohistochemistry (IHC). The results demonstrated a significant decrease in the percentage of HHEX‑positive cells in KK‑Ay mice as compared with that in KK‑α/α control mice. Furthermore, in Taiwan's Han Chinese population, genotypic and allelic frequency distributions of the rs61862780 single‑nucleotide polymorphism (SNP) in the HHEX gene were investigated. The results demonstrated that in the rs61862780 SNP of the 3'‑untranslated region (UTR) of HHEX, the frequency of the CC genotype was higher in patients (6.0%) than in controls (2.7%), while the TT genotype frequency was about equal. In the same SNP, the frequency of the C allele was higher in patients (21.0%) than in controls (17.3%), while the T allele frequency was about equal. These results may pave the road for exploring the KK‑Ay mouse model and the HHEX SNP rs61862780, which was correlated with the susceptibility to T2D in a Chinese population. Based on these findings, an association of HHEX gene expression with pathological features of T2D was indicated.
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Copy and paste a formatted citation
Spandidos Publications style
Lu CC, Chen YT, Chen SY, Hsu YM, Lin CC, Tsao JW, Juan YN, Yang JS and Tsai FJ: Hematopoietically expressed homeobox gene is associated with type 2 diabetes in KK Cg‑Ay/J mice and a Taiwanese Han Chinese population. Exp Ther Med 16: 185-191, 2018.
APA
Lu, C., Chen, Y., Chen, S., Hsu, Y., Lin, C., Tsao, J. ... Tsai, F. (2018). Hematopoietically expressed homeobox gene is associated with type 2 diabetes in KK Cg‑Ay/J mice and a Taiwanese Han Chinese population. Experimental and Therapeutic Medicine, 16, 185-191. https://doi.org/10.3892/etm.2018.6152
MLA
Lu, C., Chen, Y., Chen, S., Hsu, Y., Lin, C., Tsao, J., Juan, Y., Yang, J., Tsai, F."Hematopoietically expressed homeobox gene is associated with type 2 diabetes in KK Cg‑Ay/J mice and a Taiwanese Han Chinese population". Experimental and Therapeutic Medicine 16.1 (2018): 185-191.
Chicago
Lu, C., Chen, Y., Chen, S., Hsu, Y., Lin, C., Tsao, J., Juan, Y., Yang, J., Tsai, F."Hematopoietically expressed homeobox gene is associated with type 2 diabetes in KK Cg‑Ay/J mice and a Taiwanese Han Chinese population". Experimental and Therapeutic Medicine 16, no. 1 (2018): 185-191. https://doi.org/10.3892/etm.2018.6152
Copy and paste a formatted citation
x
Spandidos Publications style
Lu CC, Chen YT, Chen SY, Hsu YM, Lin CC, Tsao JW, Juan YN, Yang JS and Tsai FJ: Hematopoietically expressed homeobox gene is associated with type 2 diabetes in KK Cg‑Ay/J mice and a Taiwanese Han Chinese population. Exp Ther Med 16: 185-191, 2018.
APA
Lu, C., Chen, Y., Chen, S., Hsu, Y., Lin, C., Tsao, J. ... Tsai, F. (2018). Hematopoietically expressed homeobox gene is associated with type 2 diabetes in KK Cg‑Ay/J mice and a Taiwanese Han Chinese population. Experimental and Therapeutic Medicine, 16, 185-191. https://doi.org/10.3892/etm.2018.6152
MLA
Lu, C., Chen, Y., Chen, S., Hsu, Y., Lin, C., Tsao, J., Juan, Y., Yang, J., Tsai, F."Hematopoietically expressed homeobox gene is associated with type 2 diabetes in KK Cg‑Ay/J mice and a Taiwanese Han Chinese population". Experimental and Therapeutic Medicine 16.1 (2018): 185-191.
Chicago
Lu, C., Chen, Y., Chen, S., Hsu, Y., Lin, C., Tsao, J., Juan, Y., Yang, J., Tsai, F."Hematopoietically expressed homeobox gene is associated with type 2 diabetes in KK Cg‑Ay/J mice and a Taiwanese Han Chinese population". Experimental and Therapeutic Medicine 16, no. 1 (2018): 185-191. https://doi.org/10.3892/etm.2018.6152
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