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Effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats

  • Authors:
    • Mingyang Li
    • Fuyuan Liu
    • Ming Sang
    • Xiaodong Sun
    • Lu Li
    • Xiangyu Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China, Department of Cardiology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China, Department of Central Laboratory, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China, Central Laboratory, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 751-757
    |
    Published online on: May 21, 2018
       https://doi.org/10.3892/etm.2018.6201
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Abstract

The aim of the present study was to examine the effects of atorvastatinon p38 phosphorylation and cardiac remodeling after myocardial infarction in rats. A total of 43 rats were randomly divided into the control, sham operation, post-modeling medication (medication) and post-modeling non-medication (non-medication) groups. The control group did not receive any treatment. Anterior descending arteries of the rats in the medication and non‑medication groups were ligated, and threading at the anterior descending arteries was conducted for the rats in the sham operation group. Atorvastatin (10 mg/kg) was given daily to the rats in the medication group, and an equivalent amount of normal saline was given daily to the rats in the sham operation group. Four weeks later, the cardiac function, morphological changes in the myocardial cells, and the expression of tumor necrosis factor-α (TNF-α) and p38 in each group was detected. At 4 weeks after treatment, the myocardial infarction size, fibrosis and myocardial necrosis of the rats in the medication group was examined compared with those in the non‑medication group (P<0.05). The cardiac function of the rats in the non-medication group was significantly lower than that of the rats in the control and sham groups (P<0.05), while it was obviously elevated in the medication group compared with that in the non-medication group (P<0.05). The expression of TNF-α and phosphorylated p38 of the left ventricle in the non-medication group was higher than that in the control group (P<0.05), while it was obviously reduced in the non‑medication group compared with that in the control group (P<0.05). Atorvastatin can improve cardiac remodeling after myocardial infarction in rats, which may be associated with its inhibition of p38 phosphorylation and its decrease of TNF-α expression.
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Copy and paste a formatted citation
Spandidos Publications style
Li M, Liu F, Sang M, Sun X, Li L and Wang X: Effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats. Exp Ther Med 16: 751-757, 2018.
APA
Li, M., Liu, F., Sang, M., Sun, X., Li, L., & Wang, X. (2018). Effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats. Experimental and Therapeutic Medicine, 16, 751-757. https://doi.org/10.3892/etm.2018.6201
MLA
Li, M., Liu, F., Sang, M., Sun, X., Li, L., Wang, X."Effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats". Experimental and Therapeutic Medicine 16.2 (2018): 751-757.
Chicago
Li, M., Liu, F., Sang, M., Sun, X., Li, L., Wang, X."Effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats". Experimental and Therapeutic Medicine 16, no. 2 (2018): 751-757. https://doi.org/10.3892/etm.2018.6201
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Liu F, Sang M, Sun X, Li L and Wang X: Effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats. Exp Ther Med 16: 751-757, 2018.
APA
Li, M., Liu, F., Sang, M., Sun, X., Li, L., & Wang, X. (2018). Effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats. Experimental and Therapeutic Medicine, 16, 751-757. https://doi.org/10.3892/etm.2018.6201
MLA
Li, M., Liu, F., Sang, M., Sun, X., Li, L., Wang, X."Effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats". Experimental and Therapeutic Medicine 16.2 (2018): 751-757.
Chicago
Li, M., Liu, F., Sang, M., Sun, X., Li, L., Wang, X."Effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats". Experimental and Therapeutic Medicine 16, no. 2 (2018): 751-757. https://doi.org/10.3892/etm.2018.6201
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