search button
Open Access

Effect of thrombelastography on timing of coronary artery bypass grafting

  • Authors:
    • Zhiyuan Yang
    • Zhouliang Xie
    • Xueliang Pei
    • Xiaoqiang Quan
    • Deguang Feng

  • View Affiliations

  • Published online on: May 21, 2018     https://doi.org/10.3892/etm.2018.6202
  • Pages: 579-584
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The guiding value of thrombelastography (TEG) on the selection of surgical timing for patients scheduled for coronary artery bypass grafting (CABG) was investigated. A total of 90 subjects with acute coronary syndrome (ACS) treated between February 2014 and December 2016 in Henan Provincial People's Hospital were recruited. The patients received dual antiplatelet therapy (DAPT) and were scheduled for CABG. Subjects were randomly allocated into two groups, TEG group (n=45) and non‑TEG group (n=45). Patients in the TEG group withheld medications at 24 h prior to surgery and received TEG examination. Based on maximum amplitude of adenosine diphosphate (MAADP), subjects were further grouped into three sub‑groups with MAADP <35 mm, 35‑50 mm, and >50 mm, and accordingly received CABG within 1 day, 3‑5 days and 5 days later, respectively. Subjects in the control group (non‑TEG group) received CABG 5‑7 days after medication withdrawal. Chest drainage volume within 24 h after surgery and red blood cell transfusion during perioperative period were compared. Other recorded parameters were incubation period, intensive care unit length of stay, hospital stay, incidence of 30‑day adverse events and readmission rate. The average waiting time before CABG for patients of TEG group was shorter compared with the commonly recommended time. The red blood cell transfusions during perioperative period of subjects in TEG group and non‑TEG group were significantly different (P=0.23). The median hospital stay of subjects in TEG group was shorter than that of non‑TEG group (P=0.037). The bleeding amount of patients in TEG group was 220.16±80.56 ml, which was significantly lower than that of non‑TEG group (435.29±90.16). The difference was statistically significant (P=0.032). The results suggested that TEG assay‑based evaluation of platelet function for patients scheduled for CABG reasonably guides surgeons with appropriate surgical timing and reduces the amount of time patients wait to be treated.
View Figures
View References

Related Articles

Journal Cover

August-2018
Volume 16 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Yang Z, Xie Z, Pei X, Quan X and Feng D: Effect of thrombelastography on timing of coronary artery bypass grafting. Exp Ther Med 16: 579-584, 2018
APA
Yang, Z., Xie, Z., Pei, X., Quan, X., & Feng, D. (2018). Effect of thrombelastography on timing of coronary artery bypass grafting. Experimental and Therapeutic Medicine, 16, 579-584. https://doi.org/10.3892/etm.2018.6202
MLA
Yang, Z., Xie, Z., Pei, X., Quan, X., Feng, D."Effect of thrombelastography on timing of coronary artery bypass grafting". Experimental and Therapeutic Medicine 16.2 (2018): 579-584.
Chicago
Yang, Z., Xie, Z., Pei, X., Quan, X., Feng, D."Effect of thrombelastography on timing of coronary artery bypass grafting". Experimental and Therapeutic Medicine 16, no. 2 (2018): 579-584. https://doi.org/10.3892/etm.2018.6202