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Article Open Access

GSH levels affect weight loss in individuals with metabolic syndrome and obesity following dietary therapy

  • Authors:
    • Nikolaos Goutzourelas
    • Marina Orfanou
    • Ioannis Charizanis
    • George Leon
    • Demetrios A. Spandidos
    • Demetrios Kouretas
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece, Eatwalk IKE, 15124 Athens, Greece, Obesity Medical Centre, 55133 Thessaloniki, Greece, Laboratory of Clinical Virology, University of Crete, Medical School, 71409 Heraklion, Greece
    Copyright: © Goutzourelas et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 635-642
    |
    Published online on: May 23, 2018
       https://doi.org/10.3892/etm.2018.6204
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Abstract

This study examined the effects of redox status markers on metabolic syndrome (MetS) and obesity before and after dietary intervention and exercise for weight loss. A total of 103 adults suffering from MetS and obesity participated in this study and followed a personalized diet plan for 6 months. Body weight, body fat (BF) percentage (BF%), respiratory quotient (RQ) and the redox status markers, reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) and protein carbonyls (CARB), were measured twice in each individual, before and after intervention. Dietary intervention resulted in weight loss, a reduction in BF% and a decrease in RQ. The GSH levels were significantly decreased following intervention, while the levels of TBARS and CARB were not affected. Based on the initial GSH levels, the patients were divided into 2 groups as follows: The high GSH group (GSH, >3.5 µmol/g Hb) and the low GSH group (GSH <3.5 µmol/g Hb). Greater weight and BF loss were observed in patients with high GSH levels. It was observed that patients with MetS and obesity with high GSH values responded better to the dietary therapy, exhibiting more significant changes in weight and BF%. This finding underscores the importance of identifying redox status markers, particularly GSH, in obese patients with MetS. Knowing the levels of GSH may aid in developing a better design of an individualized dietary plan for individuals who wish to lose weight.
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Copy and paste a formatted citation
Spandidos Publications style
Goutzourelas N, Orfanou M, Charizanis I, Leon G, Spandidos DA and Kouretas D: GSH levels affect weight loss in individuals with metabolic syndrome and obesity following dietary therapy. Exp Ther Med 16: 635-642, 2018.
APA
Goutzourelas, N., Orfanou, M., Charizanis, I., Leon, G., Spandidos, D.A., & Kouretas, D. (2018). GSH levels affect weight loss in individuals with metabolic syndrome and obesity following dietary therapy. Experimental and Therapeutic Medicine, 16, 635-642. https://doi.org/10.3892/etm.2018.6204
MLA
Goutzourelas, N., Orfanou, M., Charizanis, I., Leon, G., Spandidos, D. A., Kouretas, D."GSH levels affect weight loss in individuals with metabolic syndrome and obesity following dietary therapy". Experimental and Therapeutic Medicine 16.2 (2018): 635-642.
Chicago
Goutzourelas, N., Orfanou, M., Charizanis, I., Leon, G., Spandidos, D. A., Kouretas, D."GSH levels affect weight loss in individuals with metabolic syndrome and obesity following dietary therapy". Experimental and Therapeutic Medicine 16, no. 2 (2018): 635-642. https://doi.org/10.3892/etm.2018.6204
Copy and paste a formatted citation
x
Spandidos Publications style
Goutzourelas N, Orfanou M, Charizanis I, Leon G, Spandidos DA and Kouretas D: GSH levels affect weight loss in individuals with metabolic syndrome and obesity following dietary therapy. Exp Ther Med 16: 635-642, 2018.
APA
Goutzourelas, N., Orfanou, M., Charizanis, I., Leon, G., Spandidos, D.A., & Kouretas, D. (2018). GSH levels affect weight loss in individuals with metabolic syndrome and obesity following dietary therapy. Experimental and Therapeutic Medicine, 16, 635-642. https://doi.org/10.3892/etm.2018.6204
MLA
Goutzourelas, N., Orfanou, M., Charizanis, I., Leon, G., Spandidos, D. A., Kouretas, D."GSH levels affect weight loss in individuals with metabolic syndrome and obesity following dietary therapy". Experimental and Therapeutic Medicine 16.2 (2018): 635-642.
Chicago
Goutzourelas, N., Orfanou, M., Charizanis, I., Leon, G., Spandidos, D. A., Kouretas, D."GSH levels affect weight loss in individuals with metabolic syndrome and obesity following dietary therapy". Experimental and Therapeutic Medicine 16, no. 2 (2018): 635-642. https://doi.org/10.3892/etm.2018.6204
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