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Effects of vitamin D on apoptosis of T-lymphocyte subsets in neonatal sepsis

  • Authors:
    • Ge Zheng
    • Minli Pan
    • Zhishu Li
    • Wenna Xiang
    • Weimin Jin
  • View Affiliations / Copyright

    Affiliations: Department of Paediatrics, Ruian People's Hospital, Wenzhou, Zhejiang 325200, P.R. China
  • Pages: 629-634
    |
    Published online on: May 24, 2018
       https://doi.org/10.3892/etm.2018.6215
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Abstract

Effect of vitamin D on apoptosis of peripheral blood T-lymphocyte subsets in treatment of neonatal sepsis was investigated. A total of 150 neonatal patients with sepsis were randomly divided into vitamin D treatment group (observation group) and treatment control group, while 100 healthy newborns were selected as healthy control group. T-lymphocyte subsets were detected by flow cytometer, the levels of tumor necrosis factor-α, interleukin-1 and calcitonin were determined by double-antibody immunoluminometric assay, and the effect of vitamin D on the above indicators in the treatment of sepsis was observed. Serum 25(OH)D (22.52±5.56 mg/l) in the treatment group was obviously increased compared with that in the treatment group (14.85±6.14 mg/l) (P<0.05), but the levels in the two groups were remarkably lower than that in the normal control group (26.38±6.56 mg/l), and the differences were statistically significant (P<0.05). Cluster of differentiation 4 (CD4+) T-lymphocyte subset in sepsis patients was obviously reduced compared with that in the healthy control group (P<0.01); the difference in comparison of CD8+ T-lymphocyte subset between sepsis patients and healthy people was not statistically significant (P>0.05). After treatment for 72 h, CD4+ T-lymphocytes were increased, and the ratio of CD4+ to CD8+ was close to 1, suggesting that the effect was superior to that in the treatment control group. The inflammatory factor levels in children with sepsis were evidently higher than those in the healthy control group (P<0.01), and high-level states of inflammatory factors were significantly improved after treatment with vitamin D for 72 h, indicating that the effect was superior to that in the treatment group. The results indicated that the prognosis of sepsis patients treated with vitamin D is improved, and the mechanism may be achieved by regulating T-lymphocyte subsets and inflammatory factors.
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1 

Kempker JA, Han JE, Tangpricha V, Ziegler TR and Martin GS: Vitamin D and sepsis: An emerging relationship. Dermatoendocrinol. 4:101–108. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Herrmann M, Farrell CL, Pusceddu I, Fabregat-Cabello N and Cavalier E: Assessment of vitamin D status - a changing landscape. Clin Chem Lab Med. 55:3–26. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Kiel DP, Streeten EA, Ohlsson C, Koller DL, et al: Common genetic determinants of vitamin D insufficiency: A genome-wide association study. Lancet. 376:180–188. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Karras SN, Fakhoury H, Muscogiuri G, Grant WB, van den Ouweland JM, Colao AM and Kotsa K: Maternal vitamin D levels during pregnancy and neonatal health: Evidence to date and clinical implications. Ther Adv Musculoskelet Dis. 8:124–135. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Chiesa C, Natale F, Pascone R, Osborn JF, Pacifico L, Bonci E and de Curtis M: C reactive protein and procalcitonin: Reference intervals for preterm and term newborns during the early neonatal period. Clin Chim Acta. 412:1053–1059. 2011. View Article : Google Scholar : PubMed/NCBI

6 

El-Mazary AM, Abdel-Maaboud M, Mohamed M and Nasef K: Vitamin D supplementation and the risk of infections in fullterm infants. Correlations with the maternal serum vitamin D. Arch Dis Child. 97:A2572012.

7 

Cetinkaya M, Cekmez F, Buyukkale G, Erener-Ercan T, Demir F, Tunc T, Aydın FN and Aydemir G: Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants. J Perinatol. 35:39–45. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Kara Elitok G, Bulbul L, Zubarioglu U, Kıray Bas E, Acar D, Uslu S and Bulbul A: How should we give vitamin D supplementation? evaluation of the pediatricians' knowledge in Turkey. Ital J Pediatr. 43:952017. View Article : Google Scholar : PubMed/NCBI

9 

Huynh J, Lu T, Liew D, Doery JC, Tudball R, Jona M, Bhamjee R and Rodda CP: Vitamin D in newborns. A randomised controlled trial comparing daily and single oral bolus vitamin D in infants. J Paediatr Child Health. 53:163–169. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Onwuneme C, Blanco A, O'Neill A, Watson B and Molloy EJ: Vitamin D enhances reactive oxygen intermediates production in phagocytic cells in term and preterm infants. Pediatr Res. 79:654–661. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Han JE, Jones JL, Tangpricha V, Brown MA, Brown LAS, Hao L, Hebbar G, Lee MJ, Liu S, Ziegler TR, et al: High dose vitamin D administration in ventilated intensive care unit patients: A pilot double blind randomized controlled trial. J Clin Transl Endocrinol. 4:59–65. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Yang LR, Li H, Yang TY, Zhang T and Zhao RC: Relationship between vitamin D deficiency and early-onset neonatal sepsis. Zhongguo Dang Dai Er Ke Za Zhi. 18:791–795. 2016.(In Chinese). PubMed/NCBI

13 

Cizmeci MN, Kanburoglu MK, Akelma AZ, Ayyildiz A, Kutukoglu I, Malli DD and Tatli MM: Cord-blood 25-hydroxyvitamin D levels and risk of early-onset neonatal sepsis: A case-control study from a tertiary care center in Turkey. Eur J Pediatr. 174:809–815. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Xiao T, Chen LP, Liu H, Xie S, Luo Y and Wu DC: The analysis of etiology and risk factors for 192 cases of neonatal sepsis. BioMed Res Int. 2017:86170762017. View Article : Google Scholar : PubMed/NCBI

15 

Nzegwu NI, Rychalsky MR, Nallu LA, Song X, Deng Y, Natusch AM, Baltimore RS, Paci GR and Bizzarro MJ: Implementation of an Antimicrobial Stewardship Program in a Neonatal Intensive Care Unit. Infect Control Hosp Epidemiol. 38:1137–1143. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Omran A, Maaroof A, Saleh MH and Abdelwahab A: Salivary C-reactive protein, mean platelet volume and neutrophil lymphocyte ratio as diagnostic markers for neonatal sepsis. J Pediatr (Rio J). 94:82–87. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Stritzke A, Mohammad K, Shah PS, Ye XY, Bhandari V, Akierman A, Harrison A, Bertelle V and Lodha A: Use and timing of surfactant administration: Impact on neonatal outcomes in extremely low gestational age infants born in Canadian Neonatal Intensive Care Units. J Matern Fetal Neonatal Med. 31:1–8. 2017. View Article : Google Scholar : PubMed/NCBI

18 

McCarthy RA, McKenna MJ, Oyefeso O, Uduma O, Murray BF, Brady JJ, Kilbane MT, Murphy JF, Twomey A, O' Donnell CP, et al: Vitamin D nutritional status in preterm infants and response to supplementation. Br J Nutr. 110:156–163. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Chen J, Bruce D and Cantorna MT: Vitamin D receptor expression controls proliferation of naïve CD8+T cells and development of CD8 mediated gastrointestinal inflammation. BMC Immunol. 15:62014. View Article : Google Scholar : PubMed/NCBI

20 

Cantorna MT, Snyder L, Lin YD and Yang L: Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients. 7:3011–3021. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Watkins RR, Lemonovich TL and Salata RA: An update on the association of vitamin D deficiency with common infectious diseases. Can J Physiol Pharmacol. 93:363–368. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Barragan M, Good M and Kolls JK: Regulation of dendritic cell function by vitamin D. Nutrients. 7:8127–8151. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Bahrami A, Mazloum SR, Maghsoudi S, Soleimani D, Khayyatzadeh SS, Arekhi S, Arya A, Mirmoosavi SJ, Ferns GA, Bahrami-Taghanaki H, et al: High dose vitamin D supplementation is associated with a reduction in depression score among adolescent girls: A nine-week follow-up study. J Diet Suppl. 15:173–182. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Wang EW, Siu PM, Pang MY, Woo J, Collins AR and Benzie IFF: Vitamin D deficiency, oxidative stress and antioxidant status: Only weak association seen in the absence of advanced age, obesity or pre-existing disease. Br J Nutr. 118:11–16. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zheng G, Pan M, Li Z, Xiang W and Jin W: Effects of vitamin D on apoptosis of T-lymphocyte subsets in neonatal sepsis. Exp Ther Med 16: 629-634, 2018.
APA
Zheng, G., Pan, M., Li, Z., Xiang, W., & Jin, W. (2018). Effects of vitamin D on apoptosis of T-lymphocyte subsets in neonatal sepsis. Experimental and Therapeutic Medicine, 16, 629-634. https://doi.org/10.3892/etm.2018.6215
MLA
Zheng, G., Pan, M., Li, Z., Xiang, W., Jin, W."Effects of vitamin D on apoptosis of T-lymphocyte subsets in neonatal sepsis". Experimental and Therapeutic Medicine 16.2 (2018): 629-634.
Chicago
Zheng, G., Pan, M., Li, Z., Xiang, W., Jin, W."Effects of vitamin D on apoptosis of T-lymphocyte subsets in neonatal sepsis". Experimental and Therapeutic Medicine 16, no. 2 (2018): 629-634. https://doi.org/10.3892/etm.2018.6215
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng G, Pan M, Li Z, Xiang W and Jin W: Effects of vitamin D on apoptosis of T-lymphocyte subsets in neonatal sepsis. Exp Ther Med 16: 629-634, 2018.
APA
Zheng, G., Pan, M., Li, Z., Xiang, W., & Jin, W. (2018). Effects of vitamin D on apoptosis of T-lymphocyte subsets in neonatal sepsis. Experimental and Therapeutic Medicine, 16, 629-634. https://doi.org/10.3892/etm.2018.6215
MLA
Zheng, G., Pan, M., Li, Z., Xiang, W., Jin, W."Effects of vitamin D on apoptosis of T-lymphocyte subsets in neonatal sepsis". Experimental and Therapeutic Medicine 16.2 (2018): 629-634.
Chicago
Zheng, G., Pan, M., Li, Z., Xiang, W., Jin, W."Effects of vitamin D on apoptosis of T-lymphocyte subsets in neonatal sepsis". Experimental and Therapeutic Medicine 16, no. 2 (2018): 629-634. https://doi.org/10.3892/etm.2018.6215
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