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Evaluation of blood vessel injury, oxidative stress and circulating inflammatory factors in an L‑NAME‑induced preeclampsia‑like rat model

  • Authors:
    • Wen Shu
    • Hanying Li
    • Hao Gong
    • Mei Zhang
    • Xiulong Niu
    • Yongqiang Ma
    • Xin Zhang
    • Wei Cai
    • Guohong Yang
    • Maoti Wei
    • Ning Yang
    • Yuming Li
  • View Affiliations / Copyright

    Affiliations: Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin 300162, P.R. China
    Copyright: © Shu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 585-594
    |
    Published online on: May 24, 2018
       https://doi.org/10.3892/etm.2018.6217
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Abstract

Preeclampsia is a pregnancy‑specific disease characterized by hypertension as well as proteinuria after the 20th week of pregnancy. Animal models are effective tools for studying the pathogenesis, diagnostic criteria and treatment methods of preeclampsia. The present study sought to establish and evaluate a preeclampsia‑like Sprague Dawley (SD) rat model using N‑nitro‑L‑arginine methyl ester (L‑NAME). Rats were randomly assigned to 7 groups (n=10 in each): Control rats and rats treated with low‑dose L‑NAME (40 mg/kg body weight/day) starting from gestational day (GD) 9, medium‑L‑NAME (75 mg/kg body weight/day) starting from GD 9 (9D ML group), high‑dose L‑NAME (125 mg/kg body weight/day) starting from GD 9, low‑dose L‑NAME starting from GD 10, medium‑dose L‑NAME starting from GD 10 and high‑dose L‑NAME starting from GD 10. Blood pressure (BP), 24‑h proteinuria, fetal intrauterine growth, histopathological changes, the plasma soluble fms‑like tyrosine kinase‑1 (sFlt‑1)/placental growth factor (PLGF) ratio and cytokine levels were evaluated. Elevated BP, increased urinary albumin excretion, severe endotheliosis, mesangial expansion and increased sFlt‑1/PLGF ratios were observed in the experimental groups compared with the control group (P<0.05), particularly in the 9D ML group. The results of the present study may optimize the conditions of the previously established L‑NAME‑induced preeclampsia SD rat model and aid further study into the pathogenesis of preeclampsia.
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1 

American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy: Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. Obstet Gynecol. 122:1122–1131. 2013.PubMed/NCBI

2 

Al-Jameil N, Aziz Khan F, Fareed Khan M and Tabassum H: A brief overview of preeclampsia. J Clin Med Res. 6:1–7. 2014.PubMed/NCBI

3 

Wang A, Rana S and Karumanchi SA: Preeclampsia: The role of angiogenic factors in its pathogenesis. Physiology (Bethesda). 24:147–158. 2009.PubMed/NCBI

4 

ACOG Committee on Obstetric Practice: ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet. 77:67–75. 2002.PubMed/NCBI

5 

Khan KS, Wojdyla D, Say L, Gülmezoglu AM and van Look PF: WHO analysis of causes of maternal death: A systematic review. Lancet. 367:1066–1074. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Steegers EA, von Dadelszen P, Duvekot JJ and Pijnenborg R: Pre-eclampsia. Lancet. 376:631–644. 2010. View Article : Google Scholar : PubMed/NCBI

7 

European Society of Gynecology (ESG); Association for European Paediatric Cardiology (AEPC); German Society for Gender Medicine (DGesGM); Regitz-Zagrosek V, Blomstrom Lundqvist C, Borghi C, Cifkova R, Ferreira R, Foidart JM, Gibbs JS, et al: ESC Guidelines on the management of cardiovascular diseases during pregnancy: The Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC). Eur Heart J. 32:3147–3197. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Soobryan N, Murugesan S, Phoswa W, Gathiram P, Moodley J and Mackraj I: The effects of sildenafil citrate on uterine angiogenic status and serum inflammatory markers in an L-NAME rat model of pre-eclampsia. Eur J Pharmacol. 795:101–107. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Jim B and Karumanchi SA: Preeclampsia: Pathogenesis, prevention, and long-term complications. Semin Nephrol. 37:386–397. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Lisonkova S and Joseph KS: Incidence of preeclampsia: Risk factors and outcomes associated with early-versus late-onset disease. Am J Obstet Gynecol. 209:544.e1–544.e12. 2013. View Article : Google Scholar

11 

Hladunewich M, Karumanchi SA and Lafayette R: Pathophysiology of the clinical manifestations of preeclampsia. Clin J Am Soc Nephrol. 2:543–549. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Roberts JM and Gammill HS: Preeclampsia: Recent insights. Hypertension. 46:1243–1249. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Lam C, Lim KH and Karumanchi SA: Circulating angiogenic factors in the pathogenesis and prediction of preeclampsia. Hypertension. 46:1077–1085. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Chaiworapongsa T, Chaemsaithong P, Yeo L and Romero R: Pre-eclampsia part 1: Current understanding of its pathophysiology. Nat Rev Nephrol. 10:466–480. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Powe CE, Levine RJ and Karumanchi SA: Preeclampsia, a disease of the maternal endothelium: The role of antiangiogenic factors and implications for later cardiovascular disease. Circulation. 123:2856–2869. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Zeisler H, Hund M and Verlohren S: The sFlt-1: PlGF ratio in women with suspected preeclampsia. N Engl J Med. 374:1785–1786. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Motta C, Grosso C, Zanuzzi C, Molinero D, Picco N, Bellingeri R, Alustiza F, Barbeito C, Vivas A and Romanini MC: Effect of Sildenafil on Pre-Eclampsia-Like Mouse Model Induced By L-Name. Reprod Domest Anim. 50:611–616. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Souza CO, Peraçoli MT, Weel IC, Bannwart CF, Romão M, Nakaira-Takahagi E, Medeiros LT, Silva MG and Peraçoli JC: Hepatoprotective and anti-inflammatory effects of silibinin on experimental preeclampsia induced by L-NAME in rats. Life Sci. 91:159–165. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Liu W, Qiao F, Liu H, Gong X, Shi X, Li Y and Wu Y: Low molecular weight heparin improves proteinuria in rats with L-NAME induced preeclampsia by decreasing the expression of nephrin, but not podocin. Hypertens Pregnancy. 34:24–35. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Rowsell HC: Program and objectives of the Canadian Council on Animal Care. Lab Anim Sci. 37:24–27. 1987.PubMed/NCBI

21 

Song Y, Shi MM, Zhang YY, Mo XD, Wang Y, Zhang XH, Xu LP, Huang XJ and Kong Y: Abnormalities of the bone marrow immune microenvironment in patients with prolonged isolated thrombocytopenia after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 23:906–912. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Chatziandreou N, Farsakoglu Y, Palomino-Segura M, D'Antuono R, Pizzagalli DU, Sallusto F, Lukacs-Kornek V, Uguccioni M, Corti D, Turley SJ, et al: Macrophage death following influenza vaccination initiates the inflammatory response that promotes dendritic cell function in the draining lymph node. Cell Rep. 18:2427–2440. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Zhu Y, Paniccia A, Schulick AC, Chen W, Koenig MR, Byers JT, Yao S, Bevers S and Edil BH: Identification of CD112R as a novel checkpoint for human T cells. J Exp Med. 213:167–176. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Gille JH, Moore DG and Sedgwick CJ: Placental infarction: A sign of pre-eclampsia in a patas monkey (Erythrocebus patas). Lab Anim Sci. 27:119–121. 1977.PubMed/NCBI

25 

Rogers JB, Klein R and Blumenthal HT: Placental permeability in a toxemia-susceptible strain of guinea pigs. Am J Obstet Gynecol. 88:495–501. 1964. View Article : Google Scholar : PubMed/NCBI

26 

Diket AL, Pierce MR, Munshi UK, Voelker CA, Eloby-Childress S, Greenberg SS, Zhang XJ, Clark DA and Miller MJ: Nitric oxide inhibition causes intrauterine growth retardation and hind-limb disruptions in rats. Am J Obstet Gynecol. 171:1243–1250. 1994. View Article : Google Scholar : PubMed/NCBI

27 

Kumasawa K, Ikawa M, Kidoya H, Hasuwa H, Saito-Fujita T, Morioka Y, Takakura N, Kimura T and Okabe M: Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model. Proc Natl Acad Sci USA. 108:1451–1455. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, et al: Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 12:642–649. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Tal R, Shaish A, Barshack I, Polak-Charcon S, Afek A, Volkov A, Feldman B, Avivi C and Harats D: Effects of hypoxia-inducible factor-1alpha overexpression in pregnant mice: Possible implications for preeclampsia and intrauterine growth restriction. Am J Pathol. 177:2950–2962. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, et al: Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature. 453:1117–1121. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Kupferminc MJ, Peaceman AM, Wigton TR, Rehnberg KA and Socol ML: Tumor necrosis factor-alpha is elevated in plasma and amniotic fluid of patients with severe preeclampsia. Am J Obstet Gynecol. 170:1752–1757; discussion 1757–1759. 1994. View Article : Google Scholar : PubMed/NCBI

32 

LaMarca BB, Bennett WA, Alexander BT, Cockrell K and Granger JP: Hypertension produced by reductions in uterine perfusion in the pregnant rat: Role of tumor necrosis factor-alpha. Hypertension. 46:1022–1025. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Wenzel K, Rajakumar A, Haase H, Geusens N, Hubner N, Schulz H, Brewer J, Roberts L, Hubel CA, Herse F, et al: Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant rats. Hypertension. 58:77–84. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Takimoto-Ohnishi E, Saito T, Ishida J, Ohnishi J, Sugiyama F, Yagami K and Fukamizu A: Differential roles of renin and angiotensinogen in the feto-maternal interface in the development of complications of pregnancy. Mol Endocrinol. 19:1361–1372. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Baksu B, Davas I, Baksu A, Akyol A and Gulbaba G: Plasma nitric oxide, endothelin-1 and urinary nitric oxide and cyclic guanosine monophosphate levels in hypertensive pregnant women. Int J Gynaecol Obstet. 90:112–117. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Vechoropoulos M, Ish-Shalom M, Shaklai S, Sack J, Stern N and Tordjman KM: The proatherogenic effect of chronic nitric oxide synthesis inhibition in ApoE-Null mice is dependent on the presence of PPAR α. PPAR Res. 2014:1245832014. View Article : Google Scholar : PubMed/NCBI

37 

Ribeiro MO, Antunes E, de Nucci G, Lovisolo SM and Zatz R: Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension. Hypertension. 20:298–303. 1992.

38 

Wang Y, Zhang F, Liu Y, Yin S, Pang X, Li Z and Wei Z: Nebivolol alleviates aortic remodeling through eNOS upregulation and inhibition of oxidative stress in l-NAME-induced hypertensive rats. Clin Exp Hypertens. 39:628–639. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Zeisler H, Llurba E, Chantraine F, Vatish M, Staff AC, Sennström M, Olovsson M, Brennecke SP, Stepan H, Allegranza D, et al: Predictive value of the sFlt-1: PlGF ratio in women with suspected preeclampsia. N Engl J Med. 374:13–22. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Amaral TAS, Ognibene DT, Carvalho LCRM, Rocha APM, Costa CA, Moura RS and Resende AC: Differential responses of mesenteric arterial bed to vasoactive substances in L-NAME-induced preeclampsia: Role of oxidative stress and endothelial dysfunction. Clin Exp Hypertens. 40:126–135. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Cornelius DC, Hogg JP, Scott J, Wallace K, Herse F, Moseley J, Wallukat G, Dechend R and LaMarca B: Administration of interleukin-17 soluble receptor C suppresses TH17 cells, oxidative stress, and hypertension in response to placental ischemia during pregnancy. Hypertension. 62:1068–1073. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Miossec P and Kolls JK: Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov. 11:763–776. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Guerby P, Vidal F, Garoby-Salom S, Vayssiere C, Salvayre R, Parant O and Negre-Salvayre A: Oxidative stress and preeclampsia: A review. Gynecol Obstet Fertil. 43:751–756. 2015.(In French). View Article : Google Scholar : PubMed/NCBI

44 

Walker JJ: Inflammation and preeclampsia. Pregnancy Hyperte-ns. 1:43–47. 2011. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Shu W, Li H, Gong H, Zhang M, Niu X, Ma Y, Zhang X, Cai W, Yang G, Wei M, Wei M, et al: Evaluation of blood vessel injury, oxidative stress and circulating inflammatory factors in an L‑NAME‑induced preeclampsia‑like rat model. Exp Ther Med 16: 585-594, 2018.
APA
Shu, W., Li, H., Gong, H., Zhang, M., Niu, X., Ma, Y. ... Li, Y. (2018). Evaluation of blood vessel injury, oxidative stress and circulating inflammatory factors in an L‑NAME‑induced preeclampsia‑like rat model. Experimental and Therapeutic Medicine, 16, 585-594. https://doi.org/10.3892/etm.2018.6217
MLA
Shu, W., Li, H., Gong, H., Zhang, M., Niu, X., Ma, Y., Zhang, X., Cai, W., Yang, G., Wei, M., Yang, N., Li, Y."Evaluation of blood vessel injury, oxidative stress and circulating inflammatory factors in an L‑NAME‑induced preeclampsia‑like rat model". Experimental and Therapeutic Medicine 16.2 (2018): 585-594.
Chicago
Shu, W., Li, H., Gong, H., Zhang, M., Niu, X., Ma, Y., Zhang, X., Cai, W., Yang, G., Wei, M., Yang, N., Li, Y."Evaluation of blood vessel injury, oxidative stress and circulating inflammatory factors in an L‑NAME‑induced preeclampsia‑like rat model". Experimental and Therapeutic Medicine 16, no. 2 (2018): 585-594. https://doi.org/10.3892/etm.2018.6217
Copy and paste a formatted citation
x
Spandidos Publications style
Shu W, Li H, Gong H, Zhang M, Niu X, Ma Y, Zhang X, Cai W, Yang G, Wei M, Wei M, et al: Evaluation of blood vessel injury, oxidative stress and circulating inflammatory factors in an L‑NAME‑induced preeclampsia‑like rat model. Exp Ther Med 16: 585-594, 2018.
APA
Shu, W., Li, H., Gong, H., Zhang, M., Niu, X., Ma, Y. ... Li, Y. (2018). Evaluation of blood vessel injury, oxidative stress and circulating inflammatory factors in an L‑NAME‑induced preeclampsia‑like rat model. Experimental and Therapeutic Medicine, 16, 585-594. https://doi.org/10.3892/etm.2018.6217
MLA
Shu, W., Li, H., Gong, H., Zhang, M., Niu, X., Ma, Y., Zhang, X., Cai, W., Yang, G., Wei, M., Yang, N., Li, Y."Evaluation of blood vessel injury, oxidative stress and circulating inflammatory factors in an L‑NAME‑induced preeclampsia‑like rat model". Experimental and Therapeutic Medicine 16.2 (2018): 585-594.
Chicago
Shu, W., Li, H., Gong, H., Zhang, M., Niu, X., Ma, Y., Zhang, X., Cai, W., Yang, G., Wei, M., Yang, N., Li, Y."Evaluation of blood vessel injury, oxidative stress and circulating inflammatory factors in an L‑NAME‑induced preeclampsia‑like rat model". Experimental and Therapeutic Medicine 16, no. 2 (2018): 585-594. https://doi.org/10.3892/etm.2018.6217
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