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Dexmedetomidine on autophagy of hippocampal neurons in aged rats under sevoflurane anesthesia

  • Authors:
    • Chunfang Yi
    • Zhiyun Fu
    • Xiaofeng Luo
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Anesthesiology, People's Hospital of Yifeng, Yifeng, Jiangxi 336300, P.R. China
  • Pages: 837-841
    |
    Published online on: May 24, 2018
       https://doi.org/10.3892/etm.2018.6219
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Abstract

Dexmedetomidine is a highly-selective α adrenergic receptor agonist, widely used as an anesthesia adjuvant drug in clinic. Effects of dexmedetomidine on autophagy of hippocampal neurons and cognitive dysfunction in aged rats under sevoflurane anesthesia were investigated. Sixty healthy Sprague-Dawley (SD) rats aged 4-6 months of either sex, weighing 150-200 g were selected and randomly divided into control group (n=10), sevoflurane group (n=25) and dexmedetomidine + sevoflurane group (compound group, n=25). The control group was inhaled with 60% O2 for 6 h, the sevoflurane group was inhaled with 3.4-3.6% sevoflurane for 6 h, and the compound group was treated with intraperitoneal injection of 4 µg/kg dexmedetomidine 1 h before the inhalation of sevoflurane. Five rats were taken from each group 1 h before sevoflurane anesthesia (T1), immediately after anesthesia (T2), 12 h after anesthesia (T3) and 24 h after anesthesia (T4), respectively. The expression levels of microtubule-associated protein 1 light-chain 3-I (LC3-I), LC3-II and Beclin-1 were detected via western blotting, and the LC3-II/LC3-I value was calculated. Moreover, Morris water maze test was performed for the five rats in each group 5 weeks after anesthesia to detect the cognitive function; the escape latency, times across platform and swimming time in target quadrant were recorded. The levels of LC3-I, LC3-II and Beclin-1 in hippocampal neurons and LC3-II/LC3-I value in sevoflurane group at T2 were significantly higher than those at T1, and they reached the peak at T3, but were decreased at T4 (P<0.05); the levels of proteins and LC3-II/LC3-I value in compound group at T2 were significantly higher than those at T1 and reached the peak, and remained unchanged at T3-T4; besides, the level of proteins and LC3-II/LC3-I values in compound group at T2-T4 were obviously lower than those in sevoflurane group (P<0.05). In sevoflurane group, the escape latency was prolonged, the times across platform were reduced and the swimming time in target quadrant was shortened compared with those in control group (P<0.05); these parameters were significantly improved in compound group compared with those in sevoflurane group and control group (P<0.05). In conclusion, dexmedetomidine can improve the cognitive dysfunction in aged rats under sevoflurane anesthesia, which is related to the decreased autophagy of hippocampal neurons.
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1 

Tao G, Zhang J, Zhang L, Dong Y, Yu B, Crosby G, Culley DJ, Zhang Y and Xie Z: Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3β activation in young mice. Anesthesiology. 121:510–527. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Rundshagen I: Postoperative cognitive dysfunction. Dtsch Arztebl Int. 111:119–125. 2014.PubMed/NCBI

3 

Nixon RA: Autophagy, amyloidogenesis and Alzheimer disease. J Cell Sci. 120:4081–4091. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, et al: Autophagy in malignant transformation and cancer progression. EMBO J. 34:856–880. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Cai Y, Arikkath J, Yang L, Guo ML, Periyasamy P and Buch S: Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders. Autophagy. 12:225–244. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Whittington RA, Virág L, Gratuze M, Petry FR, Noël A, Poitras I, Truchetti G, Marcouiller F, Papon MA, El Khoury N, et al: Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro. Neurobiol Aging. 36:2414–2428. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Ni J, Wei J, Yao Y, Jiang X, Luo L and Luo D: Effect of dexmedetomidine on preventing postoperative agitation in children: A meta-analysis. PLoS One. 10:e01284502015. View Article : Google Scholar : PubMed/NCBI

8 

Sanders RD, Giombini M, Ma D, Ohashi Y, Hossain M, Fujinaga M and Maze M: Dexmedetomidine exerts dose-dependent age-independent antinociception but age-dependent hypnosis in Fischer rats. Anesth Analg. 100:1295–1302. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Zhu M, Wang H, Zhu A, Niu K and Wang G: Meta-analysis of dexmedetomidine on emergence agitation and recovery profiles in children after sevoflurane anesthesia: Different administration and different dosage. PLoS One. 10:e01237282015. View Article : Google Scholar : PubMed/NCBI

10 

Zhang C, Hu J, Liu X and Yan J: Effects of intravenous dexmedetomidine on emergence agitation in children under sevoflurane anesthesia: A meta-analysis of randomized controlled trials. PLoS One. 9:e997182014. View Article : Google Scholar : PubMed/NCBI

11 

Liu W, Xu J, Wang H, Xu C, Ji C, Wang Y, Feng C, Zhang X, Xu Z, Wu A, et al: Isoflurane-induced spatial memory impairment by a mechanism independent of amyloid-beta levels and tau protein phosphorylation changes in aged rats. Neurol Res. 34:3–10. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Satomoto M, Satoh Y, Terui K, Miyao H, Takishima K, Ito M and Imaki J: Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice. Anesthesiology. 110:628–637. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Zhou YF, Wang QX, Zhou HY and Chen G: Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells. Acta Pharmacol Sin. 37:580–588. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Liu K, Shi Y, Guo X, Wang S, Ouyang Y, Hao M, Liu D, Qiao L, Li N, Zheng J, et al: CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2. Cell Death Dis. 5:e13232014. View Article : Google Scholar : PubMed/NCBI

15 

Trisciuoglio D, de Luca T, Desideri M, Passeri D, Gabellini C, Scarpino S, Liang C, Orlandi A and Del Bufalo D: Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth. Neoplasia. 15:315–327. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yi C, Fu Z and Luo X: Dexmedetomidine on autophagy of hippocampal neurons in aged rats under sevoflurane anesthesia. Exp Ther Med 16: 837-841, 2018.
APA
Yi, C., Fu, Z., & Luo, X. (2018). Dexmedetomidine on autophagy of hippocampal neurons in aged rats under sevoflurane anesthesia. Experimental and Therapeutic Medicine, 16, 837-841. https://doi.org/10.3892/etm.2018.6219
MLA
Yi, C., Fu, Z., Luo, X."Dexmedetomidine on autophagy of hippocampal neurons in aged rats under sevoflurane anesthesia". Experimental and Therapeutic Medicine 16.2 (2018): 837-841.
Chicago
Yi, C., Fu, Z., Luo, X."Dexmedetomidine on autophagy of hippocampal neurons in aged rats under sevoflurane anesthesia". Experimental and Therapeutic Medicine 16, no. 2 (2018): 837-841. https://doi.org/10.3892/etm.2018.6219
Copy and paste a formatted citation
x
Spandidos Publications style
Yi C, Fu Z and Luo X: Dexmedetomidine on autophagy of hippocampal neurons in aged rats under sevoflurane anesthesia. Exp Ther Med 16: 837-841, 2018.
APA
Yi, C., Fu, Z., & Luo, X. (2018). Dexmedetomidine on autophagy of hippocampal neurons in aged rats under sevoflurane anesthesia. Experimental and Therapeutic Medicine, 16, 837-841. https://doi.org/10.3892/etm.2018.6219
MLA
Yi, C., Fu, Z., Luo, X."Dexmedetomidine on autophagy of hippocampal neurons in aged rats under sevoflurane anesthesia". Experimental and Therapeutic Medicine 16.2 (2018): 837-841.
Chicago
Yi, C., Fu, Z., Luo, X."Dexmedetomidine on autophagy of hippocampal neurons in aged rats under sevoflurane anesthesia". Experimental and Therapeutic Medicine 16, no. 2 (2018): 837-841. https://doi.org/10.3892/etm.2018.6219
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