Open Access

Changes in bone mineral density and bone metabolic indexes in ankylosing spondylitis mouse model complicated with osteoporosis

  • Authors:
    • Zi-Bing Hu
    • Bo Wei
    • Shao-Ke Wu
    • Jie-Cong Sun
    • Min Xiang
    • Zhong-Min Zhang
  • View Affiliations

  • Published online on: May 24, 2018     https://doi.org/10.3892/etm.2018.6220
  • Pages: 811-815
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Abstract

Changes in bone mineral density and bone metabolic indexes in a model of ankylosing spondylitis (AS) mice complicated with osteoporosis (OP) were investigated. BLAB/c mice were used as the subjects. AS was induced using proteoglycan, and OP was induced using tail suspension method. The mice were randomly divided into four groups: AS group, OP group, AS + OP group and negative control group. Changes in bone mineral density, bone strength, serum calcium (Ca), phosphorus, alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRACP), in mice of each group were detected and compared. There were statistically significant differences in bone mineral density and bone strength among groups. Compared with the negative control group, bone mineral density and bone strength in the AS, the OP and the AS + OP groups were significantly decreased, and the lowest bone mineral density and bone strength were found in the AS + OP group (P<0.05). There were no significant differences in bone mineral density and bone strength between the AS group and the OP group. Significant differences in serum Ca, ALP and TRACP but not in serum phosphorus were found among groups. Compared with the control group, serum levels of Ca and TRACP in the AS, the OP and the AS + OP groups were significantly increased, while levels of ALP were obviously decreased (P<0.05). Bone destruction in AS mice complicated with osteoarthritis was more serious than that in mice with simple AS.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Hu Z, Wei B, Wu S, Sun J, Xiang M and Zhang Z: Changes in bone mineral density and bone metabolic indexes in ankylosing spondylitis mouse model complicated with osteoporosis. Exp Ther Med 16: 811-815, 2018
APA
Hu, Z., Wei, B., Wu, S., Sun, J., Xiang, M., & Zhang, Z. (2018). Changes in bone mineral density and bone metabolic indexes in ankylosing spondylitis mouse model complicated with osteoporosis. Experimental and Therapeutic Medicine, 16, 811-815. https://doi.org/10.3892/etm.2018.6220
MLA
Hu, Z., Wei, B., Wu, S., Sun, J., Xiang, M., Zhang, Z."Changes in bone mineral density and bone metabolic indexes in ankylosing spondylitis mouse model complicated with osteoporosis". Experimental and Therapeutic Medicine 16.2 (2018): 811-815.
Chicago
Hu, Z., Wei, B., Wu, S., Sun, J., Xiang, M., Zhang, Z."Changes in bone mineral density and bone metabolic indexes in ankylosing spondylitis mouse model complicated with osteoporosis". Experimental and Therapeutic Medicine 16, no. 2 (2018): 811-815. https://doi.org/10.3892/etm.2018.6220