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LAP+CD4+ T cells are elevated among the peripheral blood mononuclear cells and tumor tissue of patients with hepatocellular carcinoma

  • Authors:
    • Xi Ou
    • Jing Guan
    • Jing‑Sen Chen
    • Jie‑Cao Ying
    • Xiao‑Ping Liu
    • Pei‑Kai Tian
    • Ji‑Kui Liu
    • Li‑Ping Nie
    • Yang Zhao
    • Guang‑Yin Yu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Laparoscopic Surgery, Shenzhen Hospital, Peking University, Shenzhen, Guangdong 518036, P.R. China, Department of Obstetrics and Gynecology, Xiamen University Affiliated Zhongshan Hospital, Xiamen, Fujian 361004, P.R. China, Department of General Surgery, Jinhua People's Hospital, Jinhua, Zhejiang 321000, P.R. China, Department of Clinical Laboratory, Shenzhen Hospital, Peking University, Shenzhen, Guangdong 518036, P.R. China, Department of Pathology, Shenzhen Hospital, Peking University, Shenzhen, Guangdong 518036, P.R. China
    Copyright: © Ou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 788-796
    |
    Published online on: May 29, 2018
       https://doi.org/10.3892/etm.2018.6229
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Abstract

The purpose of the present study was to investigate the role of latency‑associated peptide (LAP)+CD4+ T cells in hepatocellular carcinoma (HCC) immunity. Flow cytometric analysis was performed to detect the proportion of LAP+CD4+ T cells among the peripheral blood mononuclear cells (PBMCs) of 30 HBV‑infected HCC patients at the pre‑operative and post‑operative stages, as well as 30 hepatitis B virus (HBV)‑infected volunteers as a control group. Furthermore, tumor tissues and peri‑tumor tissues from 28 patients with HCC, as well as hepatic tissues from 28 HBV‑infected patients with benign lesions were subjected to immunohistochemical analysis with double staining for LAP and CD4, and the average number of the LAP+CD4+ T cells in each visual field was quantified. The results indicated that the proportion of LAP+CD4+ T cells in the PBMCs of patients with HCC was significantly higher than that in the control group (1.84±0.85 vs. 0.73±0.39%, P=0.019), while it was significantly reduced after the operation (1.07±0.35, P=0.021), but still slightly, if not significantly, higher compared with that in the control group (P=0.342). Furthermore, the number of LAP+CD4+ T cells per high‑magnification microscopic field (magnification, x400) in the HCC tissues was 11.25±3.00, which was significantly higher than that in the peri‑cancer tissues (5.75±1.00) and that in the HBV‑infected hepatic tissues around benign lesions (2.61±0.83). In peri‑cancer tissues, LAP+CD4+ T cells were also significantly more abundant than in control tissues. Furthermore, in the HCC tissues, LAP+CD4+ T cells were present as clusters in the tumor stroma and closely associated with CD4+ T lymphocytes. By contrast, in the peri‑cancer liver tissues and HBV‑infected hepatic tissues around benign lesions, LAP+CD4+ T cells were sparsely distributed. LAP+CD4+ T cells have marked inhibitory effects, and in the peripheral blood and tumor tissues of patients with HCC, they have an important role in the suppression of anti‑tumor immunity and in the immune evasion of tumor cells.
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1 

Sayour EJ, Mclendon P, Mclendon R, de Leon G, Reynolds R, Kresak J, Sampson JH and Mitchell DA: Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma. Cancer Immunol Immunother. 64:419–427. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Yuan CH, Sun XM, Zhu CL, Liu SP, Wu L, Chen H, Feng MH, Wu K and Wang FB: Amphiregulin activates regulatory T lymphocytes and suppresses CD8+T cell-mediated anti-tumor response in hepatocellular carcinoma cells. Oncotarget. 6:32138–32153. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Bluestone JA and Abbas AK: Natural versus adaptive regulatory T cells. Nat Rev Immunol. 3:253–257. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Weiner HL: Oral tolerance for the treatment of autoimmune diseases. Annu Rev Med. 48:341–351. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Roncarolo MG and Levings MK: The role of different subsets of T regulatory cells in controlling autoimmunity. Curr Opin Immunol. 12:676–683. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Weiner HL, da Cunha AP, Quintana F and Wu H: Oral tolerance. Immunol Rev. 241:241–259. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Filaci G, Fenoglio D and Indiveri F: CD8(+) T regulatory/suppressor cells and their relationships with autoreactivity and autoimmunity. Autoimmunity. 44:51–57. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Wong CH and Kubes P: Imaging natural killer T cells in action. Immunol Cell Biol. 91:304–310. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Chen ML, Yan BS, Bando Y, Kuchroo VK and Weiner HL: Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J Immunol. 180:7327–7337. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Duan W, So T, Mehta AK, Choi H and Croft M: Inducible CD4+LAP+Foxp3-regulatory T cells suppress allergic inflammation. J Immunol. 187:6499–6507. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Ilan Y, Maron R, Tukpah AM, Maioli TU, Murugaiyan G, Yang K, Wu HY and Weiner HL: Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice. Proc Natl Acad Sci USA. 107:9765–9770. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Mahalingam J, Lin YC, Chiang JM, Su PJ, Fang JH, Chu YY, Huang CT, Chiu CT and Lin CY: LAP+CD4+ T cells are suppressors accumulated in the tumor sites and associated with the progression of colorectal cancer. Clin Cancer Res. 18:5224–5233. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Sakaguchi S, Sakaguchi N, Asano M, Itoh M and Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 155:1151–1164. 1995.PubMed/NCBI

14 

Sakaguchi S: Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol. 6:345–352. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, Hipkiss EL, Ravi S, Kowalski J, Levitsky HI, et al: Role of LAG-3 in regulatory T cells. Immunity. 21:503–513. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Miyazono K, Ichijo H and Heldin CH: Transforming growth factor-beta: Latent forms, binding proteins and receptors. Growth Factors. 8:11–22. 1993. View Article : Google Scholar : PubMed/NCBI

17 

Keski-Oja J, Koli K and von Melchner H: TGF-beta activation by traction? Trends Cell Biol. 14:657–659. 2004. View Article : Google Scholar : PubMed/NCBI

18 

McMahon GA, Dignam JD and Gentry LE: Structural characterization of the latent complex between transforming growth factor beta 1 and beta 1-latency-associated peptide. Biochem J. 313:343–351. 1996. View Article : Google Scholar : PubMed/NCBI

19 

Nakamura K, Kitani A and Strober W: Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med. 194:629–644. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Oida T, Zhang X, Goto M, Hachimura S, Totsuka M, Kaminogawa S and Weiner HL: CD4+CD25− T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism. J Immunol. 170:2516–2522. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Nakamura K, Kitani A, Fuss I, Pedersen A, Harada N, Nawata H and Strober W: TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol. 172:834–842. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Ochi H, Abraham M, Ishikawa H, Frenkel D, Yang K, Basso AS, Wu H, Chen ML, Gandhi R, Miller A, et al: Oral CD3-specific antibody suppresses autoimmun encephalomyelitis by inducing CD4+ CD25-LAP+ T cells. Nat Med. 12:627–635. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Wu HY, Maron R, Tukpah AM and Weiner HL: Mucosal anti-CD3 monoclonal antibody attenuates collagen-induced arthritis that is associated with induction of LAP+ regulatory T cells and is enhanced by administration of an emulsome-based Th2-skewing adjuvant. J Immunol. 185:3401–3407. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Wu HY, Quintana FJ and Weiner HL: Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25-LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells. J Immunol. 181:6038–6050. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Ishikawa H, Ochi H, Chen ML, Frenkel D, Maron R and Weiner HL: Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody. Diabetes. 56:2103–2109. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Akiba J, Yano H, Ogasawara S, Higaki K and Kojiro M: Expression and function of interleukin-8 in human hepatocellular carcinoma. Int J Oncol. 18:257–264. 2001.PubMed/NCBI

27 

Gandhi R, Farez MF, Wang Y, Kozoriz D, Quintana FJ and Weiner HL: Cutting edge: Human latency-associated peptide+ T cells: A novel regulatory T cell subset. J Immunol. 184:4620–4624. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Huang Y, Wang FM, Wang T, Wang YJ, Zhu ZY, Gao YT and Du Z: Tumor-infiltrating FoxP3+Tregs and CD8+T cells affect the prognosis of hepatocellular carcinoma patients. Digestion. 86:329–337. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Brunner SM, Itzel T, Rubner C, Kesselring R, Griesshammer E, Evert M, Teufel A, Schlitt HJ and Fichtner-Feigl S: Tumor-infiltrating B cells producing antitumor active immunoglobulins in resected HCC prolong patient survival. Oncotarget. 8:71002–71011. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Zhou Y, Wang B, Wu J, Zhang C, Zhou Y, Yang X, Zhou J, Guo W and Fan J: Association of preoperative EpCAM circulating tumor cells and peripheral treg cell levels with early recurrence of hepatocellular carcinoma following radical hepatic resection. BMC Cancer. 16:5062016. View Article : Google Scholar : PubMed/NCBI

31 

Zhang L, Jiang G, Yao F, Liang G, Wang F, Xu H, Wu Y, Yu X and Liu H: Osthole promotes anti-tumor immune responses in tumor-bearing mice with hepatocellular carcinoma. Immunopharmacol Immunotoxicol. 37:301–307. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Miyara M and Sakaguchi S: Natural regulatory T cells: Mechanisms of suppression. Trends Mol Med. 13:108–116. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Zhong W, Jiang ZY, Zhang L, Huang JH, Wang SJ, Liao C, Cai B, Chen LS, Zhang S, Guo Y, et al: Role of lap+cd4+t cells in the tumor microenvironment of colorectal cancer. World J Gastroenterol. 23:455–463. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ou X, Guan J, Chen JS, Ying JC, Liu XP, Tian PK, Liu JK, Nie LP, Zhao Y, Yu GY, Yu GY, et al: LAP+CD4+ T cells are elevated among the peripheral blood mononuclear cells and tumor tissue of patients with hepatocellular carcinoma. Exp Ther Med 16: 788-796, 2018.
APA
Ou, X., Guan, J., Chen, J., Ying, J., Liu, X., Tian, P. ... Yu, G. (2018). LAP+CD4+ T cells are elevated among the peripheral blood mononuclear cells and tumor tissue of patients with hepatocellular carcinoma. Experimental and Therapeutic Medicine, 16, 788-796. https://doi.org/10.3892/etm.2018.6229
MLA
Ou, X., Guan, J., Chen, J., Ying, J., Liu, X., Tian, P., Liu, J., Nie, L., Zhao, Y., Yu, G."LAP+CD4+ T cells are elevated among the peripheral blood mononuclear cells and tumor tissue of patients with hepatocellular carcinoma". Experimental and Therapeutic Medicine 16.2 (2018): 788-796.
Chicago
Ou, X., Guan, J., Chen, J., Ying, J., Liu, X., Tian, P., Liu, J., Nie, L., Zhao, Y., Yu, G."LAP+CD4+ T cells are elevated among the peripheral blood mononuclear cells and tumor tissue of patients with hepatocellular carcinoma". Experimental and Therapeutic Medicine 16, no. 2 (2018): 788-796. https://doi.org/10.3892/etm.2018.6229
Copy and paste a formatted citation
x
Spandidos Publications style
Ou X, Guan J, Chen JS, Ying JC, Liu XP, Tian PK, Liu JK, Nie LP, Zhao Y, Yu GY, Yu GY, et al: LAP+CD4+ T cells are elevated among the peripheral blood mononuclear cells and tumor tissue of patients with hepatocellular carcinoma. Exp Ther Med 16: 788-796, 2018.
APA
Ou, X., Guan, J., Chen, J., Ying, J., Liu, X., Tian, P. ... Yu, G. (2018). LAP+CD4+ T cells are elevated among the peripheral blood mononuclear cells and tumor tissue of patients with hepatocellular carcinoma. Experimental and Therapeutic Medicine, 16, 788-796. https://doi.org/10.3892/etm.2018.6229
MLA
Ou, X., Guan, J., Chen, J., Ying, J., Liu, X., Tian, P., Liu, J., Nie, L., Zhao, Y., Yu, G."LAP+CD4+ T cells are elevated among the peripheral blood mononuclear cells and tumor tissue of patients with hepatocellular carcinoma". Experimental and Therapeutic Medicine 16.2 (2018): 788-796.
Chicago
Ou, X., Guan, J., Chen, J., Ying, J., Liu, X., Tian, P., Liu, J., Nie, L., Zhao, Y., Yu, G."LAP+CD4+ T cells are elevated among the peripheral blood mononuclear cells and tumor tissue of patients with hepatocellular carcinoma". Experimental and Therapeutic Medicine 16, no. 2 (2018): 788-796. https://doi.org/10.3892/etm.2018.6229
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