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The clinical significance of Mda‑7/IL‑24 and C‑myb expression in tumor tissues of patients with diffuse large B cell lymphoma

  • Authors:
    • Ming Ma
    • Riyang Zhao
    • Xingxiao Yang
    • Lianmei Zhao
    • Lihua Liu
    • Cong Zhang
    • Xuexiao Wang
    • Baoen Shan
  • View Affiliations / Copyright

    Affiliations: Clinical Laboratory, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Infection Management, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Biotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 649-656
    |
    Published online on: May 29, 2018
       https://doi.org/10.3892/etm.2018.6230
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Abstract

Diffuse large B cell lymphoma (DLBCL) is the most common type of non‑Hodgkin's lymphoma in adults. Mda‑7/IL‑24 had been identified as a differentiation inducer of B phenotype lymphoma cells. Previous studies have revealed that knockdown of C‑myb also leads to the terminal differentiation of B cell lymphoma. The aim of the present study was to investigate the association between the expression of Mda‑7/IL‑24 and C‑myb, and their prognostic significance for DLBCL patients. The tumor tissues were collected from 72 cases of DLBCL patients and detected with reverse transcription‑quantitative polymerase chain reaction, western blotting and immunohistochemistry assays. The results showed that, the expression of Mda‑7/IL‑24 mRNA and protein was lower while the expression of C‑myb was higher in DLBCL tissues, compared with the specimens of normal lymph node tissues. Furthermore, C‑myb expression was negatively correlated with Mda‑7/IL‑24 expression at mRNA and protein levels in DLBCL tissues. The expression of Mda‑7/IL‑24 and C‑myb in DLBCL tissues was associated with some clinicopathological parameters such as clinical stage, infiltration in bone marrow, Ki67 expression level in the tumor tissues and overall survival rates. These results indicated that low expression of Mda‑7/IL‑24, along with high expression of C‑myb, are predictor for poor prognosis of DLBCL patients, suggesting that Mda‑7/IL‑24 and C‑myb may be potential targets for clinical treatment of DLBCL.
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Copy and paste a formatted citation
Spandidos Publications style
Ma M, Zhao R, Yang X, Zhao L, Liu L, Zhang C, Wang X and Shan B: The clinical significance of Mda‑7/IL‑24 and C‑myb expression in tumor tissues of patients with diffuse large B cell lymphoma. Exp Ther Med 16: 649-656, 2018.
APA
Ma, M., Zhao, R., Yang, X., Zhao, L., Liu, L., Zhang, C. ... Shan, B. (2018). The clinical significance of Mda‑7/IL‑24 and C‑myb expression in tumor tissues of patients with diffuse large B cell lymphoma. Experimental and Therapeutic Medicine, 16, 649-656. https://doi.org/10.3892/etm.2018.6230
MLA
Ma, M., Zhao, R., Yang, X., Zhao, L., Liu, L., Zhang, C., Wang, X., Shan, B."The clinical significance of Mda‑7/IL‑24 and C‑myb expression in tumor tissues of patients with diffuse large B cell lymphoma". Experimental and Therapeutic Medicine 16.2 (2018): 649-656.
Chicago
Ma, M., Zhao, R., Yang, X., Zhao, L., Liu, L., Zhang, C., Wang, X., Shan, B."The clinical significance of Mda‑7/IL‑24 and C‑myb expression in tumor tissues of patients with diffuse large B cell lymphoma". Experimental and Therapeutic Medicine 16, no. 2 (2018): 649-656. https://doi.org/10.3892/etm.2018.6230
Copy and paste a formatted citation
x
Spandidos Publications style
Ma M, Zhao R, Yang X, Zhao L, Liu L, Zhang C, Wang X and Shan B: The clinical significance of Mda‑7/IL‑24 and C‑myb expression in tumor tissues of patients with diffuse large B cell lymphoma. Exp Ther Med 16: 649-656, 2018.
APA
Ma, M., Zhao, R., Yang, X., Zhao, L., Liu, L., Zhang, C. ... Shan, B. (2018). The clinical significance of Mda‑7/IL‑24 and C‑myb expression in tumor tissues of patients with diffuse large B cell lymphoma. Experimental and Therapeutic Medicine, 16, 649-656. https://doi.org/10.3892/etm.2018.6230
MLA
Ma, M., Zhao, R., Yang, X., Zhao, L., Liu, L., Zhang, C., Wang, X., Shan, B."The clinical significance of Mda‑7/IL‑24 and C‑myb expression in tumor tissues of patients with diffuse large B cell lymphoma". Experimental and Therapeutic Medicine 16.2 (2018): 649-656.
Chicago
Ma, M., Zhao, R., Yang, X., Zhao, L., Liu, L., Zhang, C., Wang, X., Shan, B."The clinical significance of Mda‑7/IL‑24 and C‑myb expression in tumor tissues of patients with diffuse large B cell lymphoma". Experimental and Therapeutic Medicine 16, no. 2 (2018): 649-656. https://doi.org/10.3892/etm.2018.6230
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