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Effect of chitosan combined with hyaluronate on promoting the recovery of postoperative facial nerve regeneration and function in rabbits

  • Authors:
    • Huawei Liu
    • Haitao Huang
    • Wenting Bi
    • Xinying Tan
    • Runxin Li
    • Weisheng Wen
    • Wenling Song
    • Yanhua Zhang
    • Feng Zhang
    • Min Hu
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China, Department of Stomatology, The 1st Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Stomatology, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing 100026, P.R. China, Department of Quality Control, Beijing Yierkang Bioengineering Development Center, Beijing 102600, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 739-745
    |
    Published online on: May 30, 2018
       https://doi.org/10.3892/etm.2018.6238
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Abstract

To determine better solutions for postoperative nerve functional recovery, the effects of chitosan and hyaluronate on perineural scar formation and neural function recovery were investigated in 40 rabbits. Rabbits were randomized into 4 groups: A (chitosan), B (chitosan + hyaluronate), C (hyaluronate) and D (control). The rabbits underwent the same parotidectomy surgery, but different materials were used to cover the operated nerves. By evaluating specific indicators, including vibrissae motion tests, neural electrophysiological examinations and extraneural examinations, it was revealed that the amplitude of vibrissae motion of all groups had increased 6 weeks after surgery. The recovery of Group B was superior compared with all other groups at 4 and 12 weeks post‑surgery; however no significant differences were detected. Group B exhibited a great number of nerve fibers, thicker myelin sheath and greater nerve conduction velocity. In summary, the use of a chitosan conduit combined with sodium hyaluronate gel may prevent perineural scar formation in facial nerves and promote nerve functional recovery.
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Copy and paste a formatted citation
Spandidos Publications style
Liu H, Huang H, Bi W, Tan X, Li R, Wen W, Song W, Zhang Y, Zhang F, Hu M, Hu M, et al: Effect of chitosan combined with hyaluronate on promoting the recovery of postoperative facial nerve regeneration and function in rabbits. Exp Ther Med 16: 739-745, 2018.
APA
Liu, H., Huang, H., Bi, W., Tan, X., Li, R., Wen, W. ... Hu, M. (2018). Effect of chitosan combined with hyaluronate on promoting the recovery of postoperative facial nerve regeneration and function in rabbits. Experimental and Therapeutic Medicine, 16, 739-745. https://doi.org/10.3892/etm.2018.6238
MLA
Liu, H., Huang, H., Bi, W., Tan, X., Li, R., Wen, W., Song, W., Zhang, Y., Zhang, F., Hu, M."Effect of chitosan combined with hyaluronate on promoting the recovery of postoperative facial nerve regeneration and function in rabbits". Experimental and Therapeutic Medicine 16.2 (2018): 739-745.
Chicago
Liu, H., Huang, H., Bi, W., Tan, X., Li, R., Wen, W., Song, W., Zhang, Y., Zhang, F., Hu, M."Effect of chitosan combined with hyaluronate on promoting the recovery of postoperative facial nerve regeneration and function in rabbits". Experimental and Therapeutic Medicine 16, no. 2 (2018): 739-745. https://doi.org/10.3892/etm.2018.6238
Copy and paste a formatted citation
x
Spandidos Publications style
Liu H, Huang H, Bi W, Tan X, Li R, Wen W, Song W, Zhang Y, Zhang F, Hu M, Hu M, et al: Effect of chitosan combined with hyaluronate on promoting the recovery of postoperative facial nerve regeneration and function in rabbits. Exp Ther Med 16: 739-745, 2018.
APA
Liu, H., Huang, H., Bi, W., Tan, X., Li, R., Wen, W. ... Hu, M. (2018). Effect of chitosan combined with hyaluronate on promoting the recovery of postoperative facial nerve regeneration and function in rabbits. Experimental and Therapeutic Medicine, 16, 739-745. https://doi.org/10.3892/etm.2018.6238
MLA
Liu, H., Huang, H., Bi, W., Tan, X., Li, R., Wen, W., Song, W., Zhang, Y., Zhang, F., Hu, M."Effect of chitosan combined with hyaluronate on promoting the recovery of postoperative facial nerve regeneration and function in rabbits". Experimental and Therapeutic Medicine 16.2 (2018): 739-745.
Chicago
Liu, H., Huang, H., Bi, W., Tan, X., Li, R., Wen, W., Song, W., Zhang, Y., Zhang, F., Hu, M."Effect of chitosan combined with hyaluronate on promoting the recovery of postoperative facial nerve regeneration and function in rabbits". Experimental and Therapeutic Medicine 16, no. 2 (2018): 739-745. https://doi.org/10.3892/etm.2018.6238
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