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Article

Psychiatric side effects of pegylated interferon‑α and ribavirin therapy in Iranian patients with chronic hepatitis C: A meta‑analysis

  • Authors:
    • Lotfollah Davoodi
    • Babak Masoum
    • Mahmood Moosazadeh
    • Hamed Jafarpour
    • Mohammad Reza Haghshenas
    • Tahoora Mousavi
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, Mazandaran University of Medical Sciences, Sari 48147‑88458, Iran, Psychiatry and Behavioral Sciences Research Center, Department of Psychiatry, Mazandaran University of Medical Sciences and Health Service, Sari 48147‑88458, Iran, Health Science Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari 48147‑88458, Iran, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 48147‑88458, Iran, Department of Microbiology, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 48147‑88458, Iran, Student Research Committee, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 48147‑88458, Iran
  • Pages: 971-978
    |
    Published online on: June 6, 2018
       https://doi.org/10.3892/etm.2018.6255
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Abstract

An estimated 185 million people worldwide are infected with hepatitis C virus (HCV). Combination therapy with pegylated interferon‑α (peg IFN) and ribavirin is the first line of treatment against the psychiatric side effects, including mood disorders, anxiety and irritability. In the present study, all of the studies electronically published between 2000 and 2016 were retrieved using databases including Scopus, PubMed, Institute for Scientific Information, Science Direct and Google Scholar. All of the articles were independently evaluated by two reviewers and the results were compared, followed by removal of duplicate, irrelevant and re‑published studies after reviewing. The studies were assessed based on the heterogeneity of their results using the Cochrane test and I2 analysis. All groups included neuropsychiatric side effects, fatigue was reported at the highest rate in 60.41% [95% confidence interval (CI)=39.18‑81.64%] and insomnia was reported at a lower rate in 16.28% of cases (95% CI=6.59‑25.98%). In conclusion, the present meta‑analysis indicated that treatment with peg IFN + ribavirin or interferon only is associated with a wide range of neuropsychiatric side effects, including fatigue, mood disorders, anxiety, irritability, emotional ability and agitation.
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Copy and paste a formatted citation
Spandidos Publications style
Davoodi L, Masoum B, Moosazadeh M, Jafarpour H, Haghshenas MR and Mousavi T: Psychiatric side effects of pegylated interferon‑α and ribavirin therapy in Iranian patients with chronic hepatitis C: A meta‑analysis. Exp Ther Med 16: 971-978, 2018.
APA
Davoodi, L., Masoum, B., Moosazadeh, M., Jafarpour, H., Haghshenas, M.R., & Mousavi, T. (2018). Psychiatric side effects of pegylated interferon‑α and ribavirin therapy in Iranian patients with chronic hepatitis C: A meta‑analysis. Experimental and Therapeutic Medicine, 16, 971-978. https://doi.org/10.3892/etm.2018.6255
MLA
Davoodi, L., Masoum, B., Moosazadeh, M., Jafarpour, H., Haghshenas, M. R., Mousavi, T."Psychiatric side effects of pegylated interferon‑α and ribavirin therapy in Iranian patients with chronic hepatitis C: A meta‑analysis". Experimental and Therapeutic Medicine 16.2 (2018): 971-978.
Chicago
Davoodi, L., Masoum, B., Moosazadeh, M., Jafarpour, H., Haghshenas, M. R., Mousavi, T."Psychiatric side effects of pegylated interferon‑α and ribavirin therapy in Iranian patients with chronic hepatitis C: A meta‑analysis". Experimental and Therapeutic Medicine 16, no. 2 (2018): 971-978. https://doi.org/10.3892/etm.2018.6255
Copy and paste a formatted citation
x
Spandidos Publications style
Davoodi L, Masoum B, Moosazadeh M, Jafarpour H, Haghshenas MR and Mousavi T: Psychiatric side effects of pegylated interferon‑α and ribavirin therapy in Iranian patients with chronic hepatitis C: A meta‑analysis. Exp Ther Med 16: 971-978, 2018.
APA
Davoodi, L., Masoum, B., Moosazadeh, M., Jafarpour, H., Haghshenas, M.R., & Mousavi, T. (2018). Psychiatric side effects of pegylated interferon‑α and ribavirin therapy in Iranian patients with chronic hepatitis C: A meta‑analysis. Experimental and Therapeutic Medicine, 16, 971-978. https://doi.org/10.3892/etm.2018.6255
MLA
Davoodi, L., Masoum, B., Moosazadeh, M., Jafarpour, H., Haghshenas, M. R., Mousavi, T."Psychiatric side effects of pegylated interferon‑α and ribavirin therapy in Iranian patients with chronic hepatitis C: A meta‑analysis". Experimental and Therapeutic Medicine 16.2 (2018): 971-978.
Chicago
Davoodi, L., Masoum, B., Moosazadeh, M., Jafarpour, H., Haghshenas, M. R., Mousavi, T."Psychiatric side effects of pegylated interferon‑α and ribavirin therapy in Iranian patients with chronic hepatitis C: A meta‑analysis". Experimental and Therapeutic Medicine 16, no. 2 (2018): 971-978. https://doi.org/10.3892/etm.2018.6255
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