Open Access

Naringenin inhibits NG‑nitro‑L‑arginine methyl ester‑induced hypertensive left ventricular hypertrophy by decreasing angiotensin‑converting enzyme 1 expression

  • Authors:
    • Yanxiang Gao
    • Zhizhi Wang
    • Yayun Zhang
    • Yuting Liu
    • Shanshan Wang
    • Weiliang Sun
    • Jing Guo
    • Changan Yu
    • Yong Wang
    • Wei Kong
    • Jingang Zheng
  • View Affiliations

  • Published online on: June 7, 2018     https://doi.org/10.3892/etm.2018.6258
  • Pages: 867-873
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Naringenin (NGN) is a natural flavonoid that exerts antiinflammatory, antioxidant and cardioprotective effects. The present study investigated the effects of NGN on left ventricular hypertrophy in rats with NG‑nitro‑L‑arginine methyl ester (L‑NAME)‑induced hypertension, and sought to determine the underlying mechanism of action. The rats received the following by gavage daily for 56 days: L‑NAME (50 mg/kg/day) + NGN (100 mg/kg/day), L‑NAME (50 mg/kg/day) + saline, or saline + saline. Blood pressure, heart rate and body weight were recorded. Left ventricular hypertrophy was assessed by echocardiography and hematoxylin‑eosin staining. Angiotensin II (Ang II) and angiotensin‑converting enzyme 1 (ACE1), which serve a pivotal role in cardiac remodeling, were evaluated by ELISA, reverse transcription‑quantitative polymerase chain reaction and western blot analysis. NGN had no significant effect on body weight, heart rate or blood pressure. The extent of left ventricular hypertrophy in the L‑NAME + NGN group was lower than in the L‑NAME + saline group on day 56. NGN decreased Ang II and ACE1 protein levels in myocardial tissues. In conclusion, Ang II and ACE1 expression in cardiac tissue was inhibited by NGN in L‑NAME‑treated rats, which may contribute to the inhibitory effects of NGN on left ventricular hypertrophy that is induced by pressure overload.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Gao Y, Wang Z, Zhang Y, Liu Y, Wang S, Sun W, Guo J, Yu C, Wang Y, Kong W, Kong W, et al: Naringenin inhibits NG‑nitro‑L‑arginine methyl ester‑induced hypertensive left ventricular hypertrophy by decreasing angiotensin‑converting enzyme 1 expression. Exp Ther Med 16: 867-873, 2018
APA
Gao, Y., Wang, Z., Zhang, Y., Liu, Y., Wang, S., Sun, W. ... Zheng, J. (2018). Naringenin inhibits NG‑nitro‑L‑arginine methyl ester‑induced hypertensive left ventricular hypertrophy by decreasing angiotensin‑converting enzyme 1 expression. Experimental and Therapeutic Medicine, 16, 867-873. https://doi.org/10.3892/etm.2018.6258
MLA
Gao, Y., Wang, Z., Zhang, Y., Liu, Y., Wang, S., Sun, W., Guo, J., Yu, C., Wang, Y., Kong, W., Zheng, J."Naringenin inhibits NG‑nitro‑L‑arginine methyl ester‑induced hypertensive left ventricular hypertrophy by decreasing angiotensin‑converting enzyme 1 expression". Experimental and Therapeutic Medicine 16.2 (2018): 867-873.
Chicago
Gao, Y., Wang, Z., Zhang, Y., Liu, Y., Wang, S., Sun, W., Guo, J., Yu, C., Wang, Y., Kong, W., Zheng, J."Naringenin inhibits NG‑nitro‑L‑arginine methyl ester‑induced hypertensive left ventricular hypertrophy by decreasing angiotensin‑converting enzyme 1 expression". Experimental and Therapeutic Medicine 16, no. 2 (2018): 867-873. https://doi.org/10.3892/etm.2018.6258