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Article

Clinical implication of fasting glucose and systolic/diastolic blood pressure on the prevalence of periodontitis in non‑diabetic and non‑hypertensive adults using nationally representative data

  • Authors:
    • Kyungdo Han
    • Jun‑Beom Park
  • View Affiliations / Copyright

    Affiliations: Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea, Department of Periodontics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 671-678
    |
    Published online on: June 7, 2018
       https://doi.org/10.3892/etm.2018.6260
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Abstract

The prevalence of diabetes mellitus and hypertension is increasing worldwide and an association between fasting glucose/blood pressure and periodontitis has been suggested. The present study was performed to assess the association between fasting glucose and systolic/diastolic blood pressure on the prevalence of periodontitis in non‑diabetic and non‑hypertensive adults using nationally representative data. Subgroup analysis was performed to evaluate the combined effects of obesity/abdominal obesity and impaired fasting glucose. This study involved a cross‑sectional analysis using data from the Republic of Korean National Health and Nutrition Examination Survey from 2013 to 2015. A total of 8,341 respondents without diabetes and hypertension over 19 years old without missing values were included in the present study. A significant increase was observed in the prevalence of periodontitis with increasing systolic blood pressure and diastolic blood pressure. The percentage of periodontitis increased with increased glucose levels, with similar trends in glycated hemoglobin. The odds ratios (ORs) and 95% confidence intervals (CIs) for systolic blood pressure of 90≤x<100, 100≤x<110, 110≤x<120, 120≤x<130 and 130≤x<140 were 1.116 (0.591‑2.107), 1.165 (0.624‑2.175), 1.238 (0.673‑2.278), 1.008 (0.538‑1.888) and 1.042 (0.545‑1.993), respectively, when systolic blood pressure <90 was considered as a reference. The ORs and 95% CIs for glucose of 90≤x<100, 100≤x<110 and 110≤x<126 were 1.074 (0.92‑1.253), 1.214 (0.986‑1.494) and 1.358 (1.005‑1.834), respectively when glucose <90 was considered as a reference. The association between fasting glucose/blood pressure and periodontitis was confirmed by multiple logistic regression analyses after adjusting for confounding factors among non‑diabetic and non‑hypertensive Republic of Korean adults. Subgroup analysis revealed that higher ORs of periodontitis were observed in participants with impaired glucose level and obesity when compared with individuals without impaired glucose level or obesity. The results of the present study suggest that detection of fasting glucose and blood pressure may serve as a risk indicator for periodontal disease.
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View References

1 

Kim J and Amar S: Periodontal disease and systemic conditions: A bidirectional relationship. Odontology. 94:10–21. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Tatsumi Y and Ohkubo T: Hypertension with diabetes mellitus: Significance from an epidemiological perspective for Japanese. Hypertens Res. 40:795–806. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Paizan Macedo ML and Vilela-Martin JF: Is there an association between periodontitis and hypertension? Curr Cardiol Rev. 10:355–361. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Choi HM, Han K, Park YG and Park JB: Associations among oral hygiene behavior and hypertension prevalence and control: The 2008 to 2010 Korea national health and nutrition examination survey. J Periodontol. 86:866–873. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Cho NH: Diabetes burden and prevention in Korea and the Western Pacific Region. Diabetes Res Clin Pract. 106 Suppl 2:S282–S287. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Ha KH and Kim DJ: Current status of managing diabetes mellitus in Korea. Korean J Intern Med. 31:845–850. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Cade WT: Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. Phys Ther. 88:1322–1335. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Lee HY and Park JB: The Korean society of hypertension guidelines for the management of hypertension in 2013: Its essentials and key points. Pulse (Basel). 3:21–28. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Amiri AA, Maboudi A, Bahar A, Farokhfar A, Daneshvar F, Khoshgoeian HR, Nasohi M and Khalilian A: Relationship between Type 2 diabetic retinopathy and periodontal disease in iranian adults. N Am J Med Sci. 6:139–144. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Lakschevitz F, Aboodi G, Tenenbaum H and Glogauer M: Diabetes and periodontal diseases: Interplay and links. Curr Diabetes Rev. 7:433–439. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Tsakos G, Sabbah W, Hingorani AD, Netuveli G, Donos N, Watt RG and D'Aiuto F: Is periodontal inflammation associated with raised blood pressure? Evidence from a National US survey. J Hypertens. 28:2386–2393. 2010.PubMed/NCBI

12 

Nam GE, Kim do H, Cho KH, Park YG, Han KD, Choi YS, Kim SM, Ko BJ, Kim YH and Lee KS: Estimate of a predictive cut-off value for serum 25-hydroxyvitamin D reflecting abdominal obesity in Korean adolescents. Nutr Res. 32:395–402. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Wallace TM, Levy JC and Matthews DR: Use and abuse of HOMA modeling. Diabetes Care. 27:1487–1495. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Oh SW, Shin SA, Yun YH, Yoo T and Huh BY: Cut-off point of BMI and obesity-related comorbidities and mortality in middle-aged Koreans. Obes Res. 12:2031–2040. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Lee S, Park HS, Kim SM, Kwon HS, Kim DY, Kim DJ, Cho GJ, Han JH, Kim SR, Park CY, et al: Cut-off points of waist circumference for defining abdominal obesity in the Korean population. Korean J Obes. 15:1–9. 2006. View Article : Google Scholar

16 

Jeon JY, Ko SH, Kwon HS, Kim NH, Kim JH, Kim CS, Song KH, Won JC, Lim S, Choi SH, et al: Prevalence of diabetes and prediabetes according to fasting plasma glucose and HbA1c. Diabetes Metab J. 37:349–357. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Worede A, Alemu S, Gelaw YA and Abebe M: The prevalence of impaired fasting glucose and undiagnosed diabetes mellitus and associated risk factors among adults living in a rural Koladiba town, northwest Ethiopia. BMC Res Notes. 10:2512017. View Article : Google Scholar : PubMed/NCBI

18 

Kim YH, Kim DH, Lim KS, Ko BJ, Han BD, Nam GE, Park YG, Han KD, Kim JH and Cho KH: Oral health behaviors and metabolic syndrome: The 2008–2010 Korean National Health And Nutrition Examination Survey. Clin Oral Investig. 18:1517–1524. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Park JB, Han K, Park YG and Ko Y: Association between alcohol consumption and periodontal disease: The 2008 to 2010 Korea national health and nutrition examination survey. J Periodontol. 85:1521–1528. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Alberti KG and Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 15:539–553. 1998. View Article : Google Scholar : PubMed/NCBI

21 

James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, Lackland DT, LeFevre ML, MacKenzie TD, Ogedegbe O, et al: 2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 311:507–520. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Arguedas JA, Leiva V and Wright JM: Blood pressure targets for hypertension in people with diabetes mellitus. Cochrane Database Syst Rev CD008277. 2013. View Article : Google Scholar

23 

Zhang Y, Lee ET, Devereux RB, Yeh J, Best LG, Fabsitz RR and Howard BV: Prehypertension, diabetes, and cardiovascular disease risk in a population-based sample: The Strong Heart Study. Hypertension. 47:410–414. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Julius S, Nesbitt SD, Egan BM, Weber MA, Michelson EL, Kaciroti N, Black HR, Grimm RH Jr, Messerli FH, Oparil S, et al: Feasibility of treating prehypertension with an angiotensin-receptor blocker. N Engl J Med. 354:1685–1697. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Qaseem A, Wilt TJ, Rich R, Humphrey LL, Frost J and Forciea MA: Clinical Guidelines Committee of the American College of Physicians and the Commission on Health of the Public and Science of the American Academy of Family Physician: Pharmacologic treatment of hypertension in adults aged 60 years or older to higher versus lower blood pressure targets: A clinical practice guideline from the american college of physicians and the american academy of family physicians. Ann Intern Med. 166:430–437. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Xie X, Atkins E, Lv J, Bennett A, Neal B, Ninomiya T, Woodward M, MacMahon S, Turnbull F, Hillis GS, et al: Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: Updated systematic review and meta-analysis. Lancet. 387:435–443. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Arora N, Papapanou PN, Rosenbaum M, Jacobs DR Jr, Desvarieux M and Demmer RT: Periodontal infection, impaired fasting glucose and impaired glucose tolerance: Results from the continuous national health and nutrition examination survey 2009–2010. J Clin Periodontol. 41:643–652. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Islam SK, Seo M, Lee YS and Moon SS: Association of periodontitis with insulin resistance, beta-cell function and impaired fasting glucose before onset of diabetes. Endocr J. 62:981–989. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Song IS, Han K, Ryu JJ and Park JB: Association between underweight and tooth loss among Korean adults. Sci Rep. 7:415242017. View Article : Google Scholar : PubMed/NCBI

30 

Hong M, Park JB, Kim YS, Lee DH, Kim H, Lee JI, Ahn HS, Sohn TS, Lee TK, et al: Association between Cockroach-specific Immunoglobulin E and periodontitis in Korean male adults Based on Korean National Health And Nutrition Examination Survey. Sci Rep. 7:463732017. View Article : Google Scholar : PubMed/NCBI

31 

Han K, Ko Y, Park YG and Park JB: Associations between the periodontal disease in women before menopause and menstrual cycle irregularity: The 2010–2012 Korea national health and nutrition examination survey. Medicine (Baltimore). 95:e27912016. View Article : Google Scholar : PubMed/NCBI

32 

Choi HM, Han K, Park YG and Park JB: Associations between the number of natural teeth and renal dysfunction. Medicine (Baltimore). 95:e46812016. View Article : Google Scholar : PubMed/NCBI

33 

Han K and Park JB: Association between oral health behavior and periodontal disease among Korean adults: The Korea national health and nutrition examination survey. Medicine (Baltimore). 96:e61762017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Han K and Park JB: Clinical implication of fasting glucose and systolic/diastolic blood pressure on the prevalence of periodontitis in non‑diabetic and non‑hypertensive adults using nationally representative data. Exp Ther Med 16: 671-678, 2018.
APA
Han, K., & Park, J. (2018). Clinical implication of fasting glucose and systolic/diastolic blood pressure on the prevalence of periodontitis in non‑diabetic and non‑hypertensive adults using nationally representative data. Experimental and Therapeutic Medicine, 16, 671-678. https://doi.org/10.3892/etm.2018.6260
MLA
Han, K., Park, J."Clinical implication of fasting glucose and systolic/diastolic blood pressure on the prevalence of periodontitis in non‑diabetic and non‑hypertensive adults using nationally representative data". Experimental and Therapeutic Medicine 16.2 (2018): 671-678.
Chicago
Han, K., Park, J."Clinical implication of fasting glucose and systolic/diastolic blood pressure on the prevalence of periodontitis in non‑diabetic and non‑hypertensive adults using nationally representative data". Experimental and Therapeutic Medicine 16, no. 2 (2018): 671-678. https://doi.org/10.3892/etm.2018.6260
Copy and paste a formatted citation
x
Spandidos Publications style
Han K and Park JB: Clinical implication of fasting glucose and systolic/diastolic blood pressure on the prevalence of periodontitis in non‑diabetic and non‑hypertensive adults using nationally representative data. Exp Ther Med 16: 671-678, 2018.
APA
Han, K., & Park, J. (2018). Clinical implication of fasting glucose and systolic/diastolic blood pressure on the prevalence of periodontitis in non‑diabetic and non‑hypertensive adults using nationally representative data. Experimental and Therapeutic Medicine, 16, 671-678. https://doi.org/10.3892/etm.2018.6260
MLA
Han, K., Park, J."Clinical implication of fasting glucose and systolic/diastolic blood pressure on the prevalence of periodontitis in non‑diabetic and non‑hypertensive adults using nationally representative data". Experimental and Therapeutic Medicine 16.2 (2018): 671-678.
Chicago
Han, K., Park, J."Clinical implication of fasting glucose and systolic/diastolic blood pressure on the prevalence of periodontitis in non‑diabetic and non‑hypertensive adults using nationally representative data". Experimental and Therapeutic Medicine 16, no. 2 (2018): 671-678. https://doi.org/10.3892/etm.2018.6260
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