Open Access

Effects of remote ischemic post-conditioning on platelet activation of AMI patients

  • Authors:
    • Yun-Xia Qian
    • Ke-Sheng Dai
    • Li-Li Zhao
    • Xiang-Jun Yang
  • View Affiliations

  • Published online on: June 8, 2018     https://doi.org/10.3892/etm.2018.6280
  • Pages: 1273-1277
  • Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The recovery of ischemic myocardium blood perfusion is the main treatment option for acute myocardial infarction (AMI). However, this treatment option has multiple side effects that directly affect the quality of life of the patients. The activation of platelet function plays an important role in the occurrence, development and treatment of AMI. The aim of the present study was to analyze the effects of remote ischemic post‑conditioning on platelet activation of AMI patients with primary PCI treatment and clinical prognosis. A total of 71 patients with AMI were treated with primary percutaneous coronary intervention (PCI). They were randomly divided into control group (n=34) and observation group (n=37). The patients in the observation group were treated with remote ischemic post-conditioning. Further, flow cytometer was used to detect the platelet alpha granule membrane glycoprotein (CD62P) and the percentages of activated Ⅱb/Ⅲa (PAC-1). The maximum platelet aggregation rate induced by adenosine diphosphate (ADP) and arachidonic acid (AA) was measured by light transmittance aggrometer. The incidence of major adverse cardiac events (MACE) was compared between the two groups during the follow-up period of 6 months. The percentage of CD62P (24 h after PCI) in the observation group was significantly lower than control group (P<0.05). Further, the incidence of MACE in the observation group was also lower than that of the control group (P<0.05). Remote ischemic post‑conditioning could reduce the incidence of MACE in patients with AMI after primary PCI treatment. Moreover, the above observation may be related to the improvement of platelet CD62P activation.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Qian Y, Dai K, Zhao L and Yang X: Effects of remote ischemic post-conditioning on platelet activation of AMI patients. Exp Ther Med 16: 1273-1277, 2018.
APA
Qian, Y., Dai, K., Zhao, L., & Yang, X. (2018). Effects of remote ischemic post-conditioning on platelet activation of AMI patients. Experimental and Therapeutic Medicine, 16, 1273-1277. https://doi.org/10.3892/etm.2018.6280
MLA
Qian, Y., Dai, K., Zhao, L., Yang, X."Effects of remote ischemic post-conditioning on platelet activation of AMI patients". Experimental and Therapeutic Medicine 16.2 (2018): 1273-1277.
Chicago
Qian, Y., Dai, K., Zhao, L., Yang, X."Effects of remote ischemic post-conditioning on platelet activation of AMI patients". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1273-1277. https://doi.org/10.3892/etm.2018.6280