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Article

Fibroblast growth factor‑21 is a potential diagnostic factor for patients with gestational diabetes mellitus

  • Authors:
    • Chengfang Xu
    • Zhenyan Han
    • Ping Li
    • Xuejiao Li
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The Third Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China
  • Pages: 1397-1402
    |
    Published online on: June 12, 2018
       https://doi.org/10.3892/etm.2018.6291
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Abstract

Gestational diabetes mellitus (GDM) is a metabolic disease with symptoms of hyperglycemia, insulin resistance and fetal maldevelopment. Evidence has indicated that fibroblast growth factor (FGF)‑21 is a multifunctional protein and exhibits potential therapeutic value for metabolic diseases. The present study investigated the diagnostic value of FGF‑21 serum levels in patients with GDM (n=50) and age‑matched healthy individuals (n=50). It was demonstrated that the gene and protein expression levels of FGF‑21 were downregulated in adipose cells in patients with GDM compared with those in healthy individuals. The results also indicated that the serum levels of FGF‑21 were downregulated in patients with GDM compared with those in healthy individuals. In addition, it was demonstrated that blood glucose and blood pressure were higher in patients with GDM compared with those in healthy individuals. GDM patients had a markedly higher insulin resistance and glucose tolerance than healthy individuals. However, GDM patients had significantly lower serum levels of insulin than healthy individuals. It was observed that the serum levels of FGF‑21 were positively correlated with those of glucose in GDM patients. In conclusion, these results indicate that decreased FGF‑21 levels are associated with the risk of GDM, suggesting that FGF‑21 may be a potential diagnostic factor for GDM.
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1 

Popova P, Castorino K, Grineva EN and Kerr D: Gestational diabetes mellitus diagnosis and treatment goals: measurement and measures. Minerva Endocrinol. 41:421–432. 2016.

2 

Khalafallah A, Phuah E, Al-Barazan AM, Nikakis I, Radford A, Clarkson W, Trevett C, Brain T, Gebski V and Corbould A: Glycosylated haemoglobin for screening and diagnosis of gestational diabetes mellitus. BMJ Open. 6:e0110592016. View Article : Google Scholar : PubMed/NCBI

3 

Hopmans TE, van Houten C, Kasius A, Kouznetsova OI, Nguyen LA, Rooijmans SV, Voormolen DN, van Vliet EO, Franx A and Koster MP: Increased risk of type II diabetes mellitus and cardiovascular disease after gestational diabetes mellitus: A systematic review. Ned Tijdschr Geneeskd. 159:A80432015.(In Dutch). PubMed/NCBI

4 

Wei Y, Yang H, Zhu W, Li H, Yan J and Zhang C: International association of diabetes and pregnancy study group criteria is suitable for gestational diabetes mellitus diagnosis: Further evidence from China. Chin Med J (Engl). 127:3553–3556. 2014.PubMed/NCBI

5 

Kalter-Leibovici O, Freedman LS, Olmer L, Liebermann N, Heymann A, Tal O, Lerner-Geva L, Melamed N and Hod M: Screening and diagnosis of gestational diabetes mellitus: Critical appraisal of the new International Association of Diabetes in pregnancy study group recommendations on a national level. Diabetes Care. 35:1894–1896. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Tan PC, Aziz AZ, Ismail IS and Omar SZ: Gamma-glutamyltransferase, alanine transaminase and aspartate transaminase levels and the diagnosis of gestational diabetes mellitus. Clin Biochem. 45:1192–1196. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Sagili H, Kamalanathan S, Sahoo J, Lakshminarayanan S, Rani R, Jayalakshmi D and Kumar KT: Comparison of different criteria for diagnosis of gestational diabetes mellitus. Indian J Endocrinol Metab. 19:824–828. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Askari G, Iraj B, Salehi-Abargouei A, Fallah AA and Jafari T: The association between serum selenium and gestational diabetes mellitus: A systematic review and meta-analysis. J Trace Elem Med Biol. 29:195–201. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Amin M, Suksomboon N, Poolsup N and Malik O: Comparison of glyburide with metformin in treating gestational diabetes mellitus: A systematic review and meta-analysis. Clin Drug Investig. 35:343–351. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Zhuo Z, Wang A and Yu H: Effect of metformin intervention during pregnancy on the gestational diabetes mellitus in women with polycystic ovary syndrome: a systematic review and meta-analysis. J Diabetes Res. 2014:3812312014. View Article : Google Scholar : PubMed/NCBI

11 

Durovcová V, Marek J, Hána V, Matoulek M, Zikán V, Haluzíková D, Kaválková P, Lacinová Z, Krsek M and Haluzík M: Plasma concentrations of fibroblast growth factors 21 and 19 in patients with Cushing's syndrome. Physiol Res. 59:415–422. 2010.PubMed/NCBI

12 

Eto K: FGF-21, a newcomer in the field of hypertension research. J Hum Hypertens. 27:343–344. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Reinehr T, Woelfle J, Wunsch R and Roth CL: Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: A longitudinal analysis. J Clin Endocrinol Metab. 97:2143–2150. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Zhang F, Yu L, Lin X, Cheng P, He L, Li X, Lu X, Tan Y, Yang H, Cai L and Zhang C: Minireview: Roles of fibroblast growth factors 19 and 21 in metabolic regulation and chronic diseases. Mol Endocrinol. 29:1400–1413. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Wang D, Zhu W, Li J, An C and Wang Z: Serum concentrations of fibroblast growth factors 19 and 21 in women with gestational diabetes mellitus: Association with insulin resistance, adiponectin, and polycystic ovary syndrome history. PloS One. 8:e811902013. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Williams KJ, Picou AA, Kish SL, Giraldo AM, Godke RA and Bondioli KR: Isolation and characterization of porcine adipose tissue-derived adult stem cells. Cells Tissues Organs. 188:251–258. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Selinger CI, Li BT, Pavlakis N, Links M, Gill AJ, Lee A, Clarke S, Tran TN, Lum T, Yip PY, et al: Screening for ROS1 gene rearrangements in non-small-cell lung cancers using immunohistochemistry with FISH confirmation is an effective method to identify this rare target. Histopathology. 70:402–411. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Cariello M and Moschetta A: Fibroblast growth factor 21: A new liver safeguard. Hepatology. 60:792–794. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Suomalainen A, Elo JM, Pietiläinen KH, Hakonen AH, Sevastianova K, Korpela M, Isohanni P, Marjavaara SK, Tyni T, Kiuru-Enari S, et al: FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: A diagnostic study. Lancet Neurol. 10:806–818. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Lin Z, Wu Z, Yin X, Liu Y, Yan X, Lin S, Xiao J, Wang X, Feng W and Li X: Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile. PloS One. 5:e155342010. View Article : Google Scholar : PubMed/NCBI

22 

Hart AW, Baeza N, Apelqvist A and Edlund H: Attenuation of FGF signalling in mouse beta-cells leads to diabetes. Nature. 408:864–868. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Dushay J, Chui PC, Gopalakrishnan GS, Varela-Rey M, Crawley M, Fisher FM, Badman MK, Martinez-Chantar ML and Maratos-Flier E: Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology. 139:456–463. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Hotta Y, Nakamura H, Konishi M, Murata Y, Takagi H, Matsumura S, Inoue K, Fushiki T and Itoh N: Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology. 150:4625–4633. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Wang R, Yi X, Li X and Jiang X: Fibroblast growth factor-21 is positively associated with atrial fibrosis in atrial fibrillation patients with rheumatic heart disease. Int J Clin Exp Pathol. 8:14901–14908. 2015.PubMed/NCBI

26 

Chen WW, Li L, Yang GY, Li K, Qi XY, Zhu W, Tang Y, Liu H and Boden G: Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 116:65–68. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Liu MH: FGF-21 alleviates diabetes-associated vascular complications: Inhibiting NF-kB/NLRP3 inflammasome-mediated inflammation? Int J Cardiol. 185:320–321. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Xu P, Zhang Y, Song L, Khoso MH, Li J, Jiang X, He J, Li J, Ma X, Ren G and Li D: Efficacy of a combination of high and low dosage of PEGylated FGF-21 in treatment of diabetes in db/db mice. Biomed Pharmacother. 84:97–105. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu C, Han Z, Li P and Li X: Fibroblast growth factor‑21 is a potential diagnostic factor for patients with gestational diabetes mellitus. Exp Ther Med 16: 1397-1402, 2018.
APA
Xu, C., Han, Z., Li, P., & Li, X. (2018). Fibroblast growth factor‑21 is a potential diagnostic factor for patients with gestational diabetes mellitus. Experimental and Therapeutic Medicine, 16, 1397-1402. https://doi.org/10.3892/etm.2018.6291
MLA
Xu, C., Han, Z., Li, P., Li, X."Fibroblast growth factor‑21 is a potential diagnostic factor for patients with gestational diabetes mellitus". Experimental and Therapeutic Medicine 16.2 (2018): 1397-1402.
Chicago
Xu, C., Han, Z., Li, P., Li, X."Fibroblast growth factor‑21 is a potential diagnostic factor for patients with gestational diabetes mellitus". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1397-1402. https://doi.org/10.3892/etm.2018.6291
Copy and paste a formatted citation
x
Spandidos Publications style
Xu C, Han Z, Li P and Li X: Fibroblast growth factor‑21 is a potential diagnostic factor for patients with gestational diabetes mellitus. Exp Ther Med 16: 1397-1402, 2018.
APA
Xu, C., Han, Z., Li, P., & Li, X. (2018). Fibroblast growth factor‑21 is a potential diagnostic factor for patients with gestational diabetes mellitus. Experimental and Therapeutic Medicine, 16, 1397-1402. https://doi.org/10.3892/etm.2018.6291
MLA
Xu, C., Han, Z., Li, P., Li, X."Fibroblast growth factor‑21 is a potential diagnostic factor for patients with gestational diabetes mellitus". Experimental and Therapeutic Medicine 16.2 (2018): 1397-1402.
Chicago
Xu, C., Han, Z., Li, P., Li, X."Fibroblast growth factor‑21 is a potential diagnostic factor for patients with gestational diabetes mellitus". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1397-1402. https://doi.org/10.3892/etm.2018.6291
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