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Article Open Access

Fluvastatin inhibits cardiomyocyte apoptosis after myocardial infarction through Toll pathway

Corrigendum in: /10.3892/etm.2018.6881
  • Authors:
    • Lili Jia
    • Liang Wang
    • Wenxue Liu
    • Guanglei Qian
    • Xiufang Jiang
    • Zhimian Zhang
  • View Affiliations / Copyright

    Affiliations: Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Cardiology, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Pediatrics, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Obstetrics, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Health Examination Center, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1350-1354
    |
    Published online on: June 13, 2018
       https://doi.org/10.3892/etm.2018.6297
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Abstract

The present study intended to investigate the effect of fluvastatin on cardiomyocyte apoptosis after myocardial infarction in rats. Eighty myocardial infarction rat models were established and randomly divided into 4 groups (n=20): experimental group (n=20) was given fluvastatin treatment; sham operation group (n=20) and normal control group (n=20) were given saline. The dose of fluvastatin was 20 mg/(kg·d), and irrigation gavage was given for 1 week. Western blot analysis and reverse transcription-quantitative PCR (RT-qPCR) were used to detect the expression of TLR4 mRNA and protein in cardiomyocytes. TUNEL method was used to detect the apoptosis of cardiomyocytes. After fluvastatin treatment for 1 week, RT-qPCR found that compared with myocardial infarction group, the TLR4 mRNA expression of fluvastatin treatment group and normal control group was significantly increased, and the differences between groups were a statistically significant difference (p<0.05). Western blot analysis showed that compared with the myocardial infarction group, the expression of TLR4 protein in normal control group, sham operation group and fluvastatin treatment group were significantly decreased, and they all were statistically significant (p<0.05). TUNEL method found that compared with the myocardial infarction group, the fluvastatin treatment group could significantly reduce the apoptosis of cardiomyocytes (19.2±3.8%), and the difference was statistically significant (p<0.05). Fluvastatin can inhibit myocardial infarction and decrease cardiomyocyte apoptosis by increasing the expression of TLR4-like receptor.
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Copy and paste a formatted citation
Spandidos Publications style
Jia L, Wang L, Liu W, Qian G, Jiang X and Zhang Z: Fluvastatin inhibits cardiomyocyte apoptosis after myocardial infarction through Toll pathway Corrigendum in /10.3892/etm.2018.6881. Exp Ther Med 16: 1350-1354, 2018.
APA
Jia, L., Wang, L., Liu, W., Qian, G., Jiang, X., & Zhang, Z. (2018). Fluvastatin inhibits cardiomyocyte apoptosis after myocardial infarction through Toll pathway Corrigendum in /10.3892/etm.2018.6881. Experimental and Therapeutic Medicine, 16, 1350-1354. https://doi.org/10.3892/etm.2018.6297
MLA
Jia, L., Wang, L., Liu, W., Qian, G., Jiang, X., Zhang, Z."Fluvastatin inhibits cardiomyocyte apoptosis after myocardial infarction through Toll pathway Corrigendum in /10.3892/etm.2018.6881". Experimental and Therapeutic Medicine 16.2 (2018): 1350-1354.
Chicago
Jia, L., Wang, L., Liu, W., Qian, G., Jiang, X., Zhang, Z."Fluvastatin inhibits cardiomyocyte apoptosis after myocardial infarction through Toll pathway Corrigendum in /10.3892/etm.2018.6881". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1350-1354. https://doi.org/10.3892/etm.2018.6297
Copy and paste a formatted citation
x
Spandidos Publications style
Jia L, Wang L, Liu W, Qian G, Jiang X and Zhang Z: Fluvastatin inhibits cardiomyocyte apoptosis after myocardial infarction through Toll pathway Corrigendum in /10.3892/etm.2018.6881. Exp Ther Med 16: 1350-1354, 2018.
APA
Jia, L., Wang, L., Liu, W., Qian, G., Jiang, X., & Zhang, Z. (2018). Fluvastatin inhibits cardiomyocyte apoptosis after myocardial infarction through Toll pathway Corrigendum in /10.3892/etm.2018.6881. Experimental and Therapeutic Medicine, 16, 1350-1354. https://doi.org/10.3892/etm.2018.6297
MLA
Jia, L., Wang, L., Liu, W., Qian, G., Jiang, X., Zhang, Z."Fluvastatin inhibits cardiomyocyte apoptosis after myocardial infarction through Toll pathway Corrigendum in /10.3892/etm.2018.6881". Experimental and Therapeutic Medicine 16.2 (2018): 1350-1354.
Chicago
Jia, L., Wang, L., Liu, W., Qian, G., Jiang, X., Zhang, Z."Fluvastatin inhibits cardiomyocyte apoptosis after myocardial infarction through Toll pathway Corrigendum in /10.3892/etm.2018.6881". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1350-1354. https://doi.org/10.3892/etm.2018.6297
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