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Effect of lanthanum chloride on tumor growth and apoptosis in human ovarian cancer cells and xenograft animal models

  • Authors:
    • Fen Wang
    • Yuanfang Zhu
    • Shanyu Fang
    • Shuya Li
    • Sisun Liu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1143-1148
    |
    Published online on: June 13, 2018
       https://doi.org/10.3892/etm.2018.6299
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Abstract

Ovarian cancer is the leading cause of mortality resulting from gynecologic cancer. A common anti‑ovarian tumor drug is cisplatin; however, repeated use of cisplatin causes severe resistance and leads to poor long‑term survival rate in ovarian cancer patients. Recently, it was reported that lanthanum chloride (LaCl3) may inhibit tumor growth and induce apoptosis in certain cancer cells. In the present study, the effect of LaCl3 on ovarian cancer was determined in vivo and in vitro. A cisplatin‑sensitive human ovarian cancer cell line, COC1, was used in the current study. A xenograft animal model of ovarian cancer was established injecting COC1 or cisplatin‑resistant COC1 cells (COC1/DDP) cells into mice. A TUNEL assay was used to determine the apoptosis of the COC1 or COC1/DDP cells and a immunohistochemical assay was conducted to measure the expression of B‑cell lymphoma‑2, Ki67, breast cancer 1 (BRCA)1, BRCA2 and excision repair cross‑complementation group 1 in COC1 or COC1/DDP cells. It was observed that LaCl3 promoted apoptosis in COC1 and COC1/DDP cells. In addition, LaCl3 plus cisplatin led to further increase in the expression levels of tumor suppressor genes and decrease in the expression of oncogenes. Furthermore, application of LaCl3 and cisplatin inhibited tumor growth in vivo in a xenograft animal model. These results indicated the synergistic role of LaCl3 on cisplatin‑induced inhibition of cancer cell proliferation and tumor growth, providing a potential and effective candidate for the treatment of ovarian tumors.
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View References

1 

Cress RD, Chen YS, Morris CR, Petersen M and Leiserowitz GS: Characteristics of long-term survivors of epithelial ovarian cancer. Obstet Gynecol. 126:491–497. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Petrillo M, Anchora LP, Scambia G and Fagotti A: Cytoreductive surgery plus platinum-based hyperthermic intraperitoneal chemotherapy in epithelial ovarian cancer: A promising integrated approach to improve locoregional control. Oncologist. 21:532–534. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Baldwin LA, Huang B, Miller RW, Tucker T, Goodrich ST, Podzielinski I, DeSimone CP, Ueland FR, van Nagell JR and Seamon LG: Ten-year relative survival for epithelial ovarian cancer. Obstet Gynecol. 120:612–618. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Baldwin L, Ware R, Huang B, Tucker T, Goodrich S, Podzielinski I, DeSimone C, Ueland F, van Nagell J and Seamon L: Ten-year relative survival for epithelial ovarian cancer. Gynecol Oncol. 120 Suppl 1:S34–S35. 2011. View Article : Google Scholar

5 

Kapoor S: Lanthanum and its rapidly emerging role as an anti-carcinogenic agent. J Cell Biochem. 106:1932009. View Article : Google Scholar : PubMed/NCBI

6 

Durgo K, Halec I, Sola I and Franekić J: Cytotoxic and genotoxic effects of the quercetin/lanthanum complex on human cervical carcinoma cells in vitro. Arh Hig Rada Toksiko. 62:221–227. 2011. View Article : Google Scholar

7 

Shen L1, Lan Z, Sun X, Shi L, Liu Q and Ni J: Proteomic analysis of lanthanum citrate-induced apoptosis in human cervical carcinoma SiHa cells. Biometals. 23:1179–1189. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Dai Y, Li J, Li J, Yu L, Dai G, Hu A, Yuan L and Wen Z: Effects of rare earth compounds on growth and apoptosis of leukemic cell lines. In Vitro Cell Dev Biol Anim. 38:373–375. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Shi P and Huang ZW: Proteomic detection of changes in protein synthesis induced by lanthanum in BGC-823 human gastric cancer cells. Biometals. 18:89–95. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Zhang J, Li Y, Hao X, Zhang Q, Yang K, Li L, Ma L, Wang S and Li X: Recent progress in therapeutic and diagnostic applications of lanthanides. Mini Rev Med Chem. 11:678–694. 2011. View Article : Google Scholar : PubMed/NCBI

11 

The guide for the care and use of laboratory animals. Ilar J. 56:2015.

12 

Heffeter P, Jakupec MA, Körner W, Chiba P, Pirker C, Dornetshuber R, Elbling L, Sutterlüty H, Micksche M, Keppler BK and Berger W: Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24). Biochem Pharmacol. 73:1873–1886. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Heffeter P, Jakupec MA, Körner W, Wild S, von Keyserlingk NG, Elbling L, Zorbas H, Korynevska A, Knasmüller S, Sutterlüty H, et al: Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24). Biochem Pharmacol. 71:426–440. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Zhang Z, Wang J, Li J and Xu S: Telomerase-mediated apoptosis of chicken lymphoblastoid tumor cell line by lanthanum chloride. Biol Trace Elem Res. 144:657–667. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Rubio-Viqueira B, Jimeno A, Cusatis G, Zhang X, Iacobuzio-Donahue C, Karikari C, Shi C, Danenberg K, Danenberg PV, Kuramochi H, et al: An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res. 12:4652–4661. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Hausser HJ and Brenner RE: Phenotypic instability of Saos-2 cells in long-term culture. Biochem Biophys Res Commun. 333:216–222. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Kos Z and Dabbs DJ: Biomarker assessment and molecular testing for prognostication in breast cancer. Histopathology. 68:70–85. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Cleary ML, Smith SD and Sklar J: Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell. 47:19–28. 1986. View Article : Google Scholar : PubMed/NCBI

19 

van Duin M, de Wit J, Odijk H, Westerveld A, Yasui A, Koken MH, Hoeijmakers JH and Bootsma D: Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10. Cell. 44:913–923. 1986. View Article : Google Scholar : PubMed/NCBI

20 

Duncan JA, Reeves JR and Cooke TG: BRCA1 and BRCA2 proteins: Roles in health and disease. Mol Pathol. 51:237–247. 1998. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang F, Zhu Y, Fang S, Li S and Liu S: Effect of lanthanum chloride on tumor growth and apoptosis in human ovarian cancer cells and xenograft animal models. Exp Ther Med 16: 1143-1148, 2018.
APA
Wang, F., Zhu, Y., Fang, S., Li, S., & Liu, S. (2018). Effect of lanthanum chloride on tumor growth and apoptosis in human ovarian cancer cells and xenograft animal models. Experimental and Therapeutic Medicine, 16, 1143-1148. https://doi.org/10.3892/etm.2018.6299
MLA
Wang, F., Zhu, Y., Fang, S., Li, S., Liu, S."Effect of lanthanum chloride on tumor growth and apoptosis in human ovarian cancer cells and xenograft animal models". Experimental and Therapeutic Medicine 16.2 (2018): 1143-1148.
Chicago
Wang, F., Zhu, Y., Fang, S., Li, S., Liu, S."Effect of lanthanum chloride on tumor growth and apoptosis in human ovarian cancer cells and xenograft animal models". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1143-1148. https://doi.org/10.3892/etm.2018.6299
Copy and paste a formatted citation
x
Spandidos Publications style
Wang F, Zhu Y, Fang S, Li S and Liu S: Effect of lanthanum chloride on tumor growth and apoptosis in human ovarian cancer cells and xenograft animal models. Exp Ther Med 16: 1143-1148, 2018.
APA
Wang, F., Zhu, Y., Fang, S., Li, S., & Liu, S. (2018). Effect of lanthanum chloride on tumor growth and apoptosis in human ovarian cancer cells and xenograft animal models. Experimental and Therapeutic Medicine, 16, 1143-1148. https://doi.org/10.3892/etm.2018.6299
MLA
Wang, F., Zhu, Y., Fang, S., Li, S., Liu, S."Effect of lanthanum chloride on tumor growth and apoptosis in human ovarian cancer cells and xenograft animal models". Experimental and Therapeutic Medicine 16.2 (2018): 1143-1148.
Chicago
Wang, F., Zhu, Y., Fang, S., Li, S., Liu, S."Effect of lanthanum chloride on tumor growth and apoptosis in human ovarian cancer cells and xenograft animal models". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1143-1148. https://doi.org/10.3892/etm.2018.6299
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